PMID- 29235061
OWN - NLM
STAT- MEDLINE
DCOM- 20180927
LR  - 20181113
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 50
IP  - 3
DP  - 2018 Mar
TI  - Differential expression of immune factor between patients with chronic
      prostatitis/chronic pelvic pain syndrome and the healthy volunteers.
PG  - 395-399
LID - 10.1007/s11255-017-1763-z [doi]
AB  - PURPOSE: Immune mechanisms have been hypothesized to contribute to the
      development of CP/CPPS. In this study, we investigated the differential
      expression of immune factors between patients with CP/CPPS and healthy
      volunteers. METHODS: This study was registered in Australian New Zealand Clinical
      Trials Registry. Healthy volunteers and patients with CP/CPPS were enrolled in
      this study. The inclusion criteria for patients were below: (1) aged 18-45 years 
      old; (2) prostatitis-related syndrome longer than 3 months; (3) normal routine
      urine culture and negative bacterial culture in prostatic fluid. Patients were
      further classified into two groups: types IIIA and IIIB CP/CPPS according to the 
      results of EPS routine test. Serum immune markers include IgA, IgM, IgG, CD4(+)
      and CD8(+). RESULTS: There are total 23 CP/CPPS patients, including 12 type IIIB 
      and 11 type IIIA. Relatively, there are 26 healthy volunteers. The serum levels
      of IgG were higher in CP/CPPS patients compared to healthy volunteers (1141.2 +/-
      204.3 vs 1031.9 +/- 173.7 mg/L, p = 0.045), while the serum levels of CD8(+) were
      lower in CP/CPPS patients compared to healthy volunteers (492.8 +/- 185.6 vs
      640.0 +/- 246.8 cells/muL, p = 0.021). Furthermore, serum levels of IgG were
      higher in patients with IIIA CP/CPPS compared to those with IIIB (1244.3 +/-
      151.6 vs 1054.3 +/- 209.3 mg/L, p = 0.023). CONCLUSIONS: Differential levels of
      IgG and CD8(+) between CPPS patients and healthy volunteers suggest a
      contributing role of immune mechanisms to the development of CP/CPPS; and IgG may
      play an important role in inflammatory CPPS. Clinical Study registration number
      ACTRN12613000792729.
FAU - Ye, Chen
AU  - Ye C
AD  - Department of Urology, Changhai Hospital, Second Military Medical University,
      Shanghai, People's Republic of China.
FAU - Xiao, Guang'an
AU  - Xiao G
AD  - Department of Urology, Changhai Hospital, Second Military Medical University,
      Shanghai, People's Republic of China.
FAU - Xu, Jian
AU  - Xu J
AD  - Department of Urology, Changhai Hospital, Second Military Medical University,
      Shanghai, People's Republic of China.
FAU - Qin, Shengfei
AU  - Qin S
AD  - Department of Urology, Changhai Hospital, Second Military Medical University,
      Shanghai, People's Republic of China.
FAU - Luo, Yuhua
AU  - Luo Y
AD  - Department of Urology, Haining People's Hospital, QianJiang West Road, Haining
      City, ZheJiang Province, People's Republic of China. yuhualuo2015@163.com.
FAU - Chen, Guanghua
AU  - Chen G
AD  - Department of Urology, Changhai Hospital, Second Military Medical University,
      Shanghai, People's Republic of China.
FAU - Lai, H Henry
AU  - Lai HH
AD  - Division of Urologic Surgery, Washington University School of Medicine, St Louis,
      MO, 63110, USA.
FAU - Zhou, Tie
AU  - Zhou T
AD  - Department of Urology, Changhai Hospital, Second Military Medical University,
      Shanghai, People's Republic of China. wenzhoutie80@yahoo.com.
LA  - eng
SI  - ANZCTR/ACTRN12613000792729
PT  - Journal Article
DEP - 20171212
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Adult
MH  - *CD4 Lymphocyte Count
MH  - *CD8-Positive T-Lymphocytes
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Chronic Pain/*blood/classification
MH  - Healthy Volunteers
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Immunoglobulins/*blood
MH  - Male
MH  - Pelvic Pain/*blood/classification
MH  - Prostatitis/*blood/classification
MH  - Syndrome
MH  - Young Adult
OTO - NOTNLM
OT  - Chronic pelvic pain syndrome
OT  - Chronic prostatitis
OT  - Immune
EDAT- 2017/12/14 06:00
MHDA- 2018/09/28 06:00
CRDT- 2017/12/14 06:00
PHST- 2017/08/23 00:00 [received]
PHST- 2017/11/13 00:00 [accepted]
PHST- 2017/12/14 06:00 [pubmed]
PHST- 2018/09/28 06:00 [medline]
PHST- 2017/12/14 06:00 [entrez]
AID - 10.1007/s11255-017-1763-z [doi]
AID - 10.1007/s11255-017-1763-z [pii]
PST - ppublish
SO  - Int Urol Nephrol. 2018 Mar;50(3):395-399. doi: 10.1007/s11255-017-1763-z. Epub
      2017 Dec 12.