PMID- 29226953
OWN - NLM
STAT- In-Data-Review
LR  - 20180331
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 233
IP  - 7
DP  - 2018 Jul
TI  - MicroRNAs in cutaneous melanoma: Role as diagnostic and prognostic biomarkers.
PG  - 5133-5141
LID - 10.1002/jcp.26395 [doi]
AB  - Melanoma is the leading cause of skin cancer deaths in the United States, and its
      incidence has been rising steadily for the past 30 years (Aftab, Dinger, &
      Perera, 2014). A more complete understanding of the molecular mechanisms that
      drive melanomagenesis is crucial to improve diagnosis, prognostication, and
      treatment of this disease. Given that melanoma survival rates are better when the
      disease is detected early, precise diagnostic tests for early melanoma detection 
      would be extremely useful. In addition, as survival rates decrease drastically
      when the disease becomes metastatic, improved tools to more precisely identify
      high-risk patients as well as to predict treatment response are necessary. The
      role of microRNAs (miRNAs) in melanoma biology could be the key. miRNA expression
      profiling has identified several miRNAs that play a crucial role in melanoma cell
      proliferation, migration, and invasion, as well as miRNAs involved in apoptosis
      and in the immune response. Here we review the most current data on the miRNAs
      involved in melanoma as well as their potential roles as diagnostic and
      prognostic biomarkers of this disease.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Ross, Casey L
AU  - Ross CL
AUID- ORCID: http://orcid.org/0000-0002-7922-292X
AD  - Department of Dermatology, Lewis Katz School of Medicine at Temple University,
      Philadelphia, Pennsylvania.
FAU - Kaushik, Shivani
AU  - Kaushik S
AD  - Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New
      York.
FAU - Valdes-Rodriguez, Rodrigo
AU  - Valdes-Rodriguez R
AD  - Department of Dermatology, Lewis Katz School of Medicine at Temple University,
      Philadelphia, Pennsylvania.
FAU - Anvekar, Rina
AU  - Anvekar R
AD  - Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New
      York.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180119
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
OTO - NOTNLM
OT  - cell cycle
OT  - melanoma
OT  - metastasis
OT  - microRNA
OT  - molecular function
EDAT- 2017/12/12 06:00
MHDA- 2017/12/12 06:00
CRDT- 2017/12/12 06:00
PHST- 2017/09/10 00:00 [received]
PHST- 2017/12/04 00:00 [accepted]
PHST- 2017/12/12 06:00 [pubmed]
PHST- 2017/12/12 06:00 [medline]
PHST- 2017/12/12 06:00 [entrez]
AID - 10.1002/jcp.26395 [doi]
PST - ppublish
SO  - J Cell Physiol. 2018 Jul;233(7):5133-5141. doi: 10.1002/jcp.26395. Epub 2018 Jan 
      19.