PMID- 29197087
OWN - NLM
STAT- MEDLINE
DCOM- 20180730
LR  - 20181202
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 141
IP  - 1
DP  - 2018 Apr
TI  - Vaginal discharge concentrations of beta-human chorionic gonadotropin,
      creatinine, and urea for the diagnosis of premature rupture of membranes.
PG  - 97-101
LID - 10.1002/ijgo.12414 [doi]
AB  - OBJECTIVE: To determine the diagnostic value of vaginal discharge concentrations 
      of beta human chorionic gonadotropin (beta-hCG), creatinine, and urea to identify
      premature rupture of membranes (PROM). METHODS: An observational cross-sectional 
      study was conducted between 12 June, 2014, and 11 June, 2015, among 120 women who
      were admitted to an Iranian hospital at 28-41 weeks of pregnancy. Women with
      positive pooling and nitrazine test results were assigned to the PROM group
      (n=60), whereas those with negative test results were assigned to the control
      group (n=60). Samples of vaginal discharge were obtained. RESULTS: Mean
      concentrations of beta-hCG, urea, and creatinine were all higher in the PROM
      group than in the control group (all P=0.001). The diagnostic accuracies as
      defined by area under the curve for creatinine, urea, and beta-hCG were 0.891,
      0.895, and 0.908, respectively. The corresponding optimal cutoff values were
      20.33 mumol/L, 0.94 mmol/L, and 39.5 IU/L, respectively. CONCLUSION: The vaginal 
      discharge concentrations of all three markers exhibited favorable predictive
      value for the diagnosis of PROM; however, beta-hCG showed greater diagnostic
      accuracy than either urea or creatinine.
CI  - (c) 2017 International Federation of Gynecology and Obstetrics.
FAU - Bouzari, Zinatossadat
AU  - Bouzari Z
AD  - Infertility and Health Reproductive Research Center, Health Research Institute,
      Babol University of Medical Sciences, Babol, Iran.
AD  - Clinical Research Development Center of Rohani Hospital, Babol University of
      Medical Sciences, Babol, Iran.
AD  - Department of Gynecology and Obstetrics, School of Medicine, Babol University of 
      Medical Sciences, Babol, Iran.
FAU - Shahhosseini, Roza
AU  - Shahhosseini R
AD  - Student Committee Research Department of Obstetrics and Gynecology, Babol
      University of Medical Sciences, Babol, Iran.
FAU - Mohammadnetaj, Meadeh
AU  - Mohammadnetaj M
AD  - Georgetown University, Washington, DC, USA.
FAU - Barat, Shahnaz
AU  - Barat S
AD  - Infertility and Health Reproductive Research Center, Health Research Institute,
      Babol University of Medical Sciences, Babol, Iran.
AD  - Department of Gynecology and Obstetrics, School of Medicine, Babol University of 
      Medical Sciences, Babol, Iran.
AD  - Cancer Research Center, Health Research Institute, Babol University of Medical
      Sciences, Babol, Iran.
FAU - Yazdani, Shahla
AU  - Yazdani S
AD  - Infertility and Health Reproductive Research Center, Health Research Institute,
      Babol University of Medical Sciences, Babol, Iran.
AD  - Clinical Research Development Center of Rohani Hospital, Babol University of
      Medical Sciences, Babol, Iran.
AD  - Department of Gynecology and Obstetrics, School of Medicine, Babol University of 
      Medical Sciences, Babol, Iran.
AD  - Cancer Research Center, Health Research Institute, Babol University of Medical
      Sciences, Babol, Iran.
FAU - Hajian-Tilaki, Karimollah
AU  - Hajian-Tilaki K
AD  - Social Determinants of Health Research Center, Health Research Institute, Babol
      University of Medical Sciences, Babol, Iran.
AD  - Mobility Impairment Research Center, Health Research Institute, Babol University 
      of Medical Sciences, Babol, Iran.
AD  - Department of Statistics and Epidemiology, School of Medicine, Babol University
      of Medical Sciences, Babol, Iran.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180103
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
RN  - 0 (Biomarkers)
RN  - 0 (Chorionic Gonadotropin, beta Subunit, Human)
RN  - 8W8T17847W (Urea)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/metabolism
MH  - Chorionic Gonadotropin, beta Subunit, Human/*metabolism
MH  - Creatinine/metabolism
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fetal Membranes, Premature Rupture/*diagnosis
MH  - Hospitalization
MH  - Humans
MH  - Iran
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Urea/metabolism
MH  - Vaginal Discharge/*metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Creatinine
OT  - Premature rupture of membranes
OT  - Urea
OT  - beta-human chorionic gonadotropin
EDAT- 2017/12/03 06:00
MHDA- 2018/07/31 06:00
CRDT- 2017/12/03 06:00
PHST- 2017/05/06 00:00 [received]
PHST- 2017/08/13 00:00 [revised]
PHST- 2017/11/30 00:00 [accepted]
PHST- 2017/12/03 06:00 [pubmed]
PHST- 2018/07/31 06:00 [medline]
PHST- 2017/12/03 06:00 [entrez]
AID - 10.1002/ijgo.12414 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2018 Apr;141(1):97-101. doi: 10.1002/ijgo.12414. Epub 2018
      Jan 3.