PMID- 29190738
OWN - NLM
STAT- MEDLINE
DCOM- 20171229
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 11
DP  - 2017
TI  - Cervical HSV-2 infection causes cervical remodeling and increases risk for
      ascending infection and preterm birth.
PG  - e0188645
LID - 10.1371/journal.pone.0188645 [doi]
AB  - Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of 
      neonatal mortality worldwide. Cervical viral infections have been established as 
      risk factors for PTB in women, although the mechanism leading to increased risk
      is unknown. Using a mouse model of pregnancy, we determined that intra-vaginal
      HSV2 infection caused increased rates of preterm birth following an intra-vaginal
      bacterial infection. HSV2 infection resulted in histological changes in the
      cervix mimicking cervical ripening, including significant collagen remodeling and
      increased hyaluronic acid synthesis. Viral infection also caused aberrant
      expression of estrogen and progesterone receptor in the cervical epithelium.
      Further analysis using human ectocervical cells demonstrated a role for Src
      kinase in virus-mediated changes in estrogen receptor and hyaluronic acid
      expression. In conclusion, HSV2 affects proteins involved in tissue hormone
      responsiveness, causes significant changes reminiscent of premature cervical
      ripening, and increases risk of preterm birth. Studies such as this improve our
      chances of identifying clinical interventions in the future.
FAU - McGee, Devin
AU  - McGee D
AD  - Department of Obstetrics, Gynecology and Reproductive Biology, College of Human
      Medicine, Michigan State University, Grand Rapids, MI, United States of America.
FAU - Smith, Arianna
AU  - Smith A
AUID- ORCID: http://orcid.org/0000-0003-0025-3932
AD  - Department of Obstetrics, Gynecology and Reproductive Biology, College of Human
      Medicine, Michigan State University, Grand Rapids, MI, United States of America.
FAU - Poncil, Sharra
AU  - Poncil S
AD  - Department of Obstetrics, Gynecology and Reproductive Biology, College of Human
      Medicine, Michigan State University, Grand Rapids, MI, United States of America.
FAU - Patterson, Amanda
AU  - Patterson A
AD  - Department of Obstetrics, Gynecology and Reproductive Biology, College of Human
      Medicine, Michigan State University, Grand Rapids, MI, United States of America.
FAU - Bernstein, Alison I
AU  - Bernstein AI
AUID- ORCID: http://orcid.org/0000-0002-5589-4318
AD  - Department of Translational Science and Molecular Medicine, College of Human
      Medicine, Grand Rapids, MI, United States of America.
FAU - Racicot, Karen
AU  - Racicot K
AUID- ORCID: http://orcid.org/0000-0002-2887-2543
AD  - Department of Obstetrics, Gynecology and Reproductive Biology, College of Human
      Medicine, Michigan State University, Grand Rapids, MI, United States of America.
LA  - eng
GR  - T32 HD087166/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20171130
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
EIN - PLoS One. 2018 Jun 18;13(6):e0199566. PMID: 29912991
MH  - Animals
MH  - *Cervical Length Measurement
MH  - Escherichia coli Infections/complications/physiopathology
MH  - Female
MH  - Herpes Genitalis/complications/*pathology/physiopathology
MH  - Herpesvirus 2, Human/*pathogenicity
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Animal
MH  - Pregnancy
MH  - *Premature Birth
PMC - PMC5708831
EDAT- 2017/12/01 06:00
MHDA- 2017/12/30 06:00
CRDT- 2017/12/01 06:00
PHST- 2017/06/23 00:00 [received]
PHST- 2017/11/10 00:00 [accepted]
PHST- 2017/12/01 06:00 [entrez]
PHST- 2017/12/01 06:00 [pubmed]
PHST- 2017/12/30 06:00 [medline]
AID - 10.1371/journal.pone.0188645 [doi]
AID - PONE-D-17-23891 [pii]
PST - epublish
SO  - PLoS One. 2017 Nov 30;12(11):e0188645. doi: 10.1371/journal.pone.0188645.
      eCollection 2017.