PMID- 29146875
OWN - NLM
STAT- MEDLINE
DCOM- 20171219
LR  - 20180308
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 48
IP  - 12
DP  - 2017 Dec
TI  - Risk of Stroke in Patients With Short-Run Atrial Tachyarrhythmia.
PG  - 3232-3238
LID - 10.1161/STROKEAHA.117.018475 [doi]
AB  - BACKGROUND AND PURPOSE: The risk of stroke in patients with short-run atrial
      tachyarrhythmia (AT) remains unclear. This study aimed to investigate the
      relationship between short-run AT and the stroke and the use of the CHA2DS2-VASc 
      score for the risk stratification. METHODS: From the registry of 24-hour Holter
      monitoring, 5342 subjects without known atrial fibrillation or stroke were
      enrolled. Short-run AT was defined as episodes of supraventricular ectopic beats 
      <5 seconds. RESULTS: There were 1595 subjects (29.8%) with short-run AT. During
      the median follow-up period of 9.0 years, 494 subjects developed new-onset
      stroke. Patients with short-run AT had significantly higher stroke rates compared
      with patients without short-run AT (11.4% versus 8.3%; P<0.001). In patients with
      short-run AT, the number of strokes per 100 person-years for patients with
      CHA2DS2-VASc score of 0 and 1 were 0.23 and 0.67, respectively. However, the
      number of them for patients with CHA2DS2-VASc score of 2, 3, 4, and >/=5 were
      1.62, 1.89, 1.30, and 2.91, respectively. In patients with CHA2DS2-VASc score of 
      0 or 1, age (>61 years old) and burden of premature atrial contractions (>25
      beats/d) independently predicted the risk of stroke. In subgroup analyses,
      short-run AT patients were divided into 3 groups based on their CHA2DS2-VASc
      scores: low score (score of 0 [men] or 1 [women]; n=324), intermediate score
      (score of 1 [men] or 2 [women]; n=275), and high score (score of >/=2 [men] or
      >/=3 [women]; n=996). When compared with low score, intermediate and high scores 
      were independent predictors for stroke (hazard ratio, 6.165; P<0.001 and hazard
      ratio, 8.577; P<0.001, respectively). CONCLUSIONS: Short-run AT increases the
      risk of stroke. Therefore, the CHA2DS2-VASc score could be used for the risk
      stratification. Age and burden of premature atrial contractions were independent 
      predictors for stroke in patients with CHA2DS2-VASc score of 0 or 1.
CI  - (c) 2017 American Heart Association, Inc.
FAU - Yamada, Shinya
AU  - Yamada S
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Lin, Chin-Yu
AU  - Lin CY
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Chang, Shih-Lin
AU  - Chang SL
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.). slchang4@vghtpe.gov.tw.
FAU - Chao, Tze-Fan
AU  - Chao TF
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Lin, Yenn-Jiang
AU  - Lin YJ
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Lo, Li-Wei
AU  - Lo LW
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Chung, Fa-Po
AU  - Chung FP
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Hu, Yu-Feng
AU  - Hu YF
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Tuan, Ta-Chuan
AU  - Tuan TC
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Liao, Jo-Nan
AU  - Liao JN
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Te, Abigail Louise D
AU  - Te ALD
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Chang, Yao-Ting
AU  - Chang YT
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Chang, Ting-Yung
AU  - Chang TY
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Wu, Cheng-I
AU  - Wu CI
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Higa, Satoshi
AU  - Higa S
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
FAU - Chen, Shih-Ann
AU  - Chen SA
AD  - From the Division of Cardiology, Department of Medicine, Taipei Veterans General 
      Hospital, Taiwan (S.Y., C.-Y.L., S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C.,
      Y.-F.H., T.-C.T., J.-N.L., A.L.D.T., Y.-T.C., T.-Y.C., C.-I.W., S.-A.C.);
      Department of Cardiovascular Medicine, Fukushima Medical University, Japan
      (S.Y.); Institution of Clinical Medicine, National Yang-Ming University School of
      Medicine, Taipei, Taiwan (S.-L.C., T.-F.C., Y.-J.L., L.-W.L., F.-P.C., Y.-F.H.,
      T.-C.T., J.-N.L., S.-A.C.); Department of Medicine, Taipei Veterans General
      Hospital, Yuan-Shan Branch, Yilan, Taiwan (C.-Y.L.); and Cardiac
      Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine,
      Makiminato Central Hospital, Okinawa, Japan (S.H.).
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20171116
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/complications/epidemiology
MH  - Electrocardiography, Ambulatory
MH  - Endpoint Determination
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Stroke/*epidemiology/*etiology
MH  - Tachycardia/*complications/*epidemiology
MH  - Tachycardia, Ectopic Atrial/complications/epidemiology
OTO - NOTNLM
OT  - *CHA2DS2-VASc score
OT  - *risk stratification
OT  - *short-run atrial tachyarrhythmia
OT  - *stroke
EDAT- 2017/11/18 06:00
MHDA- 2017/12/20 06:00
CRDT- 2017/11/18 06:00
PHST- 2017/06/20 00:00 [received]
PHST- 2017/10/02 00:00 [revised]
PHST- 2017/10/04 00:00 [accepted]
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2017/12/20 06:00 [medline]
PHST- 2017/11/18 06:00 [entrez]
AID - STROKEAHA.117.018475 [pii]
AID - 10.1161/STROKEAHA.117.018475 [doi]
PST - ppublish
SO  - Stroke. 2017 Dec;48(12):3232-3238. doi: 10.1161/STROKEAHA.117.018475. Epub 2017
      Nov 16.