PMID- 29145741
OWN - NLM
STAT- In-Data-Review
LR  - 20180405
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Linking)
VI  - 34
IP  - 3
DP  - 2018 Mar
TI  - A Cohort Approach to Real-Time Detection of Acute HIV Infections Among People Who
      Inject Drugs in St. Petersburg, Russia.
PG  - 261-268
LID - 10.1089/AID.2017.0076 [doi]
AB  - To detect acute HIV infections (AHIs) in real time among people who inject drugs 
      (PWID) in St. Petersburg, Russia and to test the feasibility of this approach.
      Prospective cohort study. One hundred seronegative or acutely HIV-infected at
      screening PWID were enrolled and followed until the end of the 12-month pilot
      period. Each participant was evaluated, tested, and counseled for HIV monthly.
      Two HIV tests were used: HIV antibody and HIV RNA PCR. If diagnosed with AHI,
      participants were followed weekly for a month; then, monthly for 3 months; and
      then, quarterly for the duration of the follow-up period. HIV risk behavior was
      assessed at each study visit. Most enrolled PWID were 30-39 years old, male,
      completed high school or more, not employed full-time, heroin users, and
      frequently shared injection paraphernalia. AHI prevalence at screening was 1.8%
      [95% confidence interval (CI): 0.4, 5.5]. Three participants with AHI at
      enrollment represented 3% (95% CI: 0.6, 8.5) of the 100 participants who
      consented to enroll. Among the HIV-uninfected participants (n = 97), the AHI
      incidence over time was 9.3 per 100 person-years. Persons with AHI were more
      likely to report alcohol intoxication within the prior 30 days. This was the
      first study to detect AHI using a cohort approach. The approach proved to be
      feasible: recruitment, retention, AHI detection, and virological endpoints were
      successfully reached. A cost analysis in a real-world setting would be required
      to determine if this strategy could be brought to scale. The study revealed
      continued high HIV incidence rate among PWID in St. Petersburg, Russia and the
      importance of prevention and treatment programs for this group.
FAU - Toussova, Olga V
AU  - Toussova OV
AD  - 1 Pavlov First Saint Petersburg State Medical University , St. Petersburg, Russia
      .
FAU - Kozlov, Andrei P
AU  - Kozlov AP
AD  - 2 The Biomedical Center , St. Petersburg, Russia .
AD  - 3 Peter the Great St. Petersburg Polytechnic University , St. Petersburg, Russia 
      .
FAU - Verevochkin, Sergei V
AU  - Verevochkin SV
AD  - 2 The Biomedical Center , St. Petersburg, Russia .
AD  - 3 Peter the Great St. Petersburg Polytechnic University , St. Petersburg, Russia 
      .
FAU - Lancaster, Kathryn E
AU  - Lancaster KE
AD  - 4 Department of Medicine, University of North Carolina , Chapel Hill, North
      Carolina.
FAU - Shaboltas, Alla V
AU  - Shaboltas AV
AD  - 5 St. Petersburg State University , St. Petersburg, Russia .
FAU - Masharsky, Alexei
AU  - Masharsky A
AD  - 5 St. Petersburg State University , St. Petersburg, Russia .
FAU - Dukhovlinova, Elena
AU  - Dukhovlinova E
AD  - 2 The Biomedical Center , St. Petersburg, Russia .
AD  - 6 University of North Carolina , Lineberger Comprehensive Cancer Center, Chapel
      Hill, North Carolina.
FAU - Miller, William C
AU  - Miller WC
AD  - 4 Department of Medicine, University of North Carolina , Chapel Hill, North
      Carolina.
FAU - Hoffman, Irving F
AU  - Hoffman IF
AD  - 4 Department of Medicine, University of North Carolina , Chapel Hill, North
      Carolina.
LA  - eng
PT  - Journal Article
DEP - 20180117
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
PMC - PMC5863101
OTO - NOTNLM
OT  - PWID cohort
OT  - Russia
OT  - acute HIV incidence
EDAT- 2017/11/18 06:00
MHDA- 2017/11/18 06:00
CRDT- 2017/11/18 06:00
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2017/11/18 06:00 [medline]
PHST- 2017/11/18 06:00 [entrez]
AID - 10.1089/AID.2017.0076 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2018 Mar;34(3):261-268. doi: 10.1089/AID.2017.0076.
      Epub 2018 Jan 17.