PMID- 29145609
OWN - NLM
STAT- In-Data-Review
LR  - 20180419
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 66
IP  - 9
DP  - 2018 Apr 17
TI  - The Differential Effects of Human Immunodeficiency Virus and Hepatitis C Virus on
      Bone Microarchitecture and Fracture Risk.
PG  - 1442-1447
LID - 10.1093/cid/cix1011 [doi]
AB  - Background: Human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected
      individuals have a significantly greater osteoporotic fracture risk than
      HIV-monoinfected persons, despite the fact that HIV/HCV coinfection has not been 
      associated with lower bone mineral density (BMD) than HIV or HCV alone. To
      evaluate if changes in bone microarchitecture, measured by trabecular bone score 
      (TBS), could explain these differences, we performed a prospective,
      cross-sectional cohort study of virologically suppressed HIV-infected subjects,
      untreated HCV-infected subjects, HIV/HCV-coinfected subjects, and uninfected
      controls. Methods: We enrolled 532 male subjects: 57 HIV/HCV coinfected, 174 HIV 
      infected, 123 HCV infected, and 178 controls. We conducted analysis of covariance
      comparing BMD and TBS between groups, controlling for age, race, body mass index,
      and smoking. We used linear regression to evaluate predictors of BMD and TBS and 
      evaluated the effects of severity of HCV infection and tenofovir disoproxil
      fumarate use. Results: Despite both infections being associated with decreased
      BMD, only HCV, but not HIV, was associated with lower TBS score. Also,
      HIV/HCV-coinfected subjects had lower TBS scores than HIV-monoinfected,
      HCV-monoinfected, and uninfected subjects. Neither the use of TDF or HCV viremia 
      nor the severity of HCV liver disease was associated with lower TBS. Conclusions:
      HCV infection is associated with microarchitectural changes at the lumbar spine
      as assessed by the low TBS score, suggesting that microstructural abnormalities
      underlie some of the higher fracture risk in HCV infection. TBS might improve
      fracture risk prediction in HCV infection.
FAU - Bedimo, Roger J
AU  - Bedimo RJ
AD  - Department of Medicine, Veterans Affairs North Texas Health Care System and the
      University of Texas Southwestern Medical Center at Dallas.
FAU - Adams-Huet, Beverley
AU  - Adams-Huet B
AD  - Department of Clinical Sciences, University of Texas Southwestern Medical Center 
      at Dallas.
FAU - Poindexter, John
AU  - Poindexter J
AD  - Center for Mineral Metabolism, University of Texas Southwestern Medical Center at
      Dallas.
FAU - Brown, Geri
AU  - Brown G
AD  - Department of Medicine, Veterans Affairs North Texas Health Care System and the
      University of Texas Southwestern Medical Center at Dallas.
FAU - Farukhi, Irfan
AU  - Farukhi I
AD  - Department of Nuclear Medicine, Veterans Affairs North Texas Health Care System
      and the University of Texas Southwestern Medical Center at Dallas.
FAU - Castanon, Rosinda
AU  - Castanon R
AD  - Department of Nuclear Medicine, Veterans Affairs North Texas Health Care System
      and the University of Texas Southwestern Medical Center at Dallas.
FAU - Turner, Diana
AU  - Turner D
AD  - Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas.
FAU - Moore, Teresa
AU  - Moore T
AD  - Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas.
FAU - Tebas, Pablo
AU  - Tebas P
AD  - Department of Medicine, University of Pennsylvania, Philadelphia.
FAU - Maalouf, Naim M
AU  - Maalouf NM
AD  - Department of Medicine, University of Texas Southwestern Medical Center at
      Dallas.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases
      Society of America
JID - 9203213
EDAT- 2017/11/18 06:00
MHDA- 2017/11/18 06:00
CRDT- 2017/11/18 06:00
PHST- 2017/06/30 00:00 [received]
PHST- 2017/11/13 00:00 [accepted]
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2017/11/18 06:00 [medline]
PHST- 2017/11/18 06:00 [entrez]
AID - 4627992 [pii]
AID - 10.1093/cid/cix1011 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2018 Apr 17;66(9):1442-1447. doi: 10.1093/cid/cix1011.