PMID- 29143319
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20180222
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 180
IP  - 2
DP  - 2018 Jan
TI  - The full spectrum of Castleman disease: 273 patients studied over 20 years.
PG  - 206-216
LID - 10.1111/bjh.15019 [doi]
AB  - The spectrum of Castleman disease (CD) has considerably extended since its first 
      description in 1956. Recently, an international collaborative working group has
      reached consensus on the diagnostic criteria and classification of CD. We herein 
      report 273 patients with lymph node histopathology consistent with CD and
      investigate the newly established diagnostic criteria. Twenty of these patients
      with Castleman-like histopathology were removed from analyses, because they were 
      diagnosed with an exclusionary disorder (18 with haematological malignancy).
      Among the 253 remaining patients, 57 were considered unicentric CD (UCD), 169
      were multicentric CD associated with Human Herpesvirus 8 (HHV-8+MCD), including
      140 patients with human immunodeficiency virus (HIV) infection and 29 patients
      without HIV infection, and 27 were HHV-8 negative/idiopathic multicentric CD
      (iMCD). 2-((18) F)fluoro-2-deoxy-D-glucose positron emission tomography/computed 
      tomography was useful in 62 patients for staging/classification of the disease
      and for excluding associated lymphoma. UCD was mainly associated with
      hyaline-vascular histopathological features, and most patients were asymptomatic.
      Of the 27 patients that we had originally diagnosed with iMCD, 26 met the newly
      established diagnostic criteria. Patients with iMCD and HHV-8+ MCD demonstrated
      similar characteristics, including fever, splenomegaly, cytopenia and
      inflammatory symptoms. However, the disease was more aggressive in HHV-8+ MCD,
      particularly in HIV-infected patients.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Oksenhendler, Eric
AU  - Oksenhendler E
AUID- ORCID: 0000-0001-8588-7138
AD  - Department of Clinical Immunology, Hopital Saint-Louis, Assistance Publique
      Hopitaux de Paris (APHP), Paris, France.
AD  - EA3518, Universite Paris Diderot Paris 7, Paris, France.
AD  - National Reference Centre for Castleman Disease (CRMdC), Paris, France.
FAU - Boutboul, David
AU  - Boutboul D
AD  - Department of Clinical Immunology, Hopital Saint-Louis, Assistance Publique
      Hopitaux de Paris (APHP), Paris, France.
AD  - National Reference Centre for Castleman Disease (CRMdC), Paris, France.
FAU - Fajgenbaum, David
AU  - Fajgenbaum D
AD  - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Mirouse, Adrien
AU  - Mirouse A
AD  - Department of Clinical Immunology, Hopital Saint-Louis, Assistance Publique
      Hopitaux de Paris (APHP), Paris, France.
FAU - Fieschi, Claire
AU  - Fieschi C
AD  - Department of Clinical Immunology, Hopital Saint-Louis, Assistance Publique
      Hopitaux de Paris (APHP), Paris, France.
AD  - National Reference Centre for Castleman Disease (CRMdC), Paris, France.
AD  - Inserm U1126, Centre Hayem, Hopital Saint-Louis, Paris, France.
AD  - Universite Paris Diderot Paris 7, Paris, France.
FAU - Malphettes, Marion
AU  - Malphettes M
AUID- ORCID: 0000-0002-9888-2528
AD  - Department of Clinical Immunology, Hopital Saint-Louis, Assistance Publique
      Hopitaux de Paris (APHP), Paris, France.
AD  - National Reference Centre for Castleman Disease (CRMdC), Paris, France.
AD  - Inserm U1126, Centre Hayem, Hopital Saint-Louis, Paris, France.
FAU - Vercellino, Laetitia
AU  - Vercellino L
AD  - Department of Nuclear Medicine, Hopital Saint-Louis, Assistance Publique Hopitaux
      de Paris (APHP), Paris, France.
FAU - Meignin, Veronique
AU  - Meignin V
AD  - National Reference Centre for Castleman Disease (CRMdC), Paris, France.
AD  - Department of Pathology, Hopital Saint-Louis, Assistance Publique Hopitaux de
      Paris (APHP), Paris, France.
FAU - Gerard, Laurence
AU  - Gerard L
AD  - Department of Clinical Immunology, Hopital Saint-Louis, Assistance Publique
      Hopitaux de Paris (APHP), Paris, France.
AD  - EA3518, Universite Paris Diderot Paris 7, Paris, France.
AD  - National Reference Centre for Castleman Disease (CRMdC), Paris, France.
FAU - Galicier, Lionel
AU  - Galicier L
AD  - Department of Clinical Immunology, Hopital Saint-Louis, Assistance Publique
      Hopitaux de Paris (APHP), Paris, France.
AD  - EA3518, Universite Paris Diderot Paris 7, Paris, France.
AD  - National Reference Centre for Castleman Disease (CRMdC), Paris, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171116
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Biomarkers)
SB  - IM
CIN - Br J Haematol. 2018 Jan;180(2):173-174. PMID: 29143317
MH  - Adult
MH  - Biomarkers
MH  - Biopsy
MH  - Castleman Disease/*diagnosis/etiology/mortality/therapy
MH  - Combined Modality Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Positron Emission Tomography Computed Tomography
MH  - Radiography, Thoracic
MH  - Symptom Assessment
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - *Castleman disease
OT  - *HHV-8
OT  - *HIV
OT  - *PET-CT
EDAT- 2017/11/17 06:00
MHDA- 2018/02/23 06:00
CRDT- 2017/11/17 06:00
PHST- 2017/07/07 00:00 [received]
PHST- 2017/09/19 00:00 [accepted]
PHST- 2017/11/17 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
PHST- 2017/11/17 06:00 [entrez]
AID - 10.1111/bjh.15019 [doi]
PST - ppublish
SO  - Br J Haematol. 2018 Jan;180(2):206-216. doi: 10.1111/bjh.15019. Epub 2017 Nov 16.