PMID- 29141905
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20190401
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 102
IP  - 8
DP  - 2018 Aug
TI  - Adaptive optics imaging of inherited retinal diseases.
PG  - 1028-1035
LID - 10.1136/bjophthalmol-2017-311328 [doi]
AB  - Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping
      on a microscopic scale, thereby helping to improve our understanding of retinal
      diseases. An increasing number of natural history studies and ongoing/planned
      interventional clinical trials exploit AO ophthalmoscopy both for participant
      selection, stratification and monitoring treatment safety and efficacy. In this
      review, we briefly discuss the evolution of AO ophthalmoscopy, recent
      developments and its application to a broad range of inherited retinal diseases, 
      including Stargardt disease, retinitis pigmentosa and achromatopsia. Finally, we 
      describe the impact of this in vivo microscopic imaging on our understanding of
      disease pathogenesis, clinical trial design and outcome metrics, while
      recognising the limitation of the small cohorts reported to date.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text
      of the article) 2018. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Georgiou, Michalis
AU  - Georgiou M
AUID- ORCID: 0000-0001-6397-8071
AD  - UCL Institute of Ophthalmology, University College London, London, UK.
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
FAU - Kalitzeos, Angelos
AU  - Kalitzeos A
AD  - UCL Institute of Ophthalmology, University College London, London, UK.
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
FAU - Patterson, Emily J
AU  - Patterson EJ
AD  - Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin,
      Milwaukee, Wisconsin, USA.
FAU - Dubra, Alfredo
AU  - Dubra A
AD  - Department of Ophthalmology, Stanford University, Palo Alto, California, USA.
FAU - Carroll, Joseph
AU  - Carroll J
AUID- ORCID: 0000-0002-8640-1029
AD  - Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin,
      Milwaukee, Wisconsin, USA.
FAU - Michaelides, Michel
AU  - Michaelides M
AD  - UCL Institute of Ophthalmology, University College London, London, UK.
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - R01 EY017607/EY/NEI NIH HHS/United States
GR  - U01 EY025477/EY/NEI NIH HHS/United States
GR  - 099173/Z/12/Z/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171115
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Eye Diseases, Hereditary/*diagnostic imaging
MH  - Humans
MH  - *Ophthalmoscopy
MH  - Optics and Photonics/*instrumentation
MH  - Retinal Diseases/*diagnostic imaging/genetics
PMC - PMC6059037
OTO - NOTNLM
OT  - *genetics
OT  - *imaging
OT  - *retina
OT  - *vision
COIS- Competing interests: None declared.
EDAT- 2017/11/17 06:00
MHDA- 2019/04/02 06:00
CRDT- 2017/11/17 06:00
PHST- 2017/09/15 00:00 [received]
PHST- 2017/10/23 00:00 [revised]
PHST- 2017/11/04 00:00 [accepted]
PHST- 2017/11/17 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2017/11/17 06:00 [entrez]
AID - bjophthalmol-2017-311328 [pii]
AID - 10.1136/bjophthalmol-2017-311328 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2018 Aug;102(8):1028-1035. doi:
      10.1136/bjophthalmol-2017-311328. Epub 2017 Nov 15.