PMID- 29141853
OWN - NLM
STAT- In-Process
LR  - 20181024
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 27
IP  - 2
DP  - 2018 Feb
TI  - The Effects of Resistance Exercise on Biomarkers of Breast Cancer Prognosis: A
      Pooled Analysis of Three Randomized Trials.
PG  - 146-153
LID - 10.1158/1055-9965.EPI-17-0766 [doi]
AB  - Background: Using a secondary data analysis from randomized controlled trials
      comparing one year of resistance exercise (n = 109) to a placebo control
      condition (n = 106) in postmenopausal, posttreatment breast cancer survivors, we 
      investigated the influence of resistance training and changes in body composition
      on markers associated with cancer progression.Methods: Measures included serum
      levels of insulin, IGF-1, IGFBP1-3, leptin, serum amyloid A (SAA), adiponectin,
      C-reactive protein (CRP), IL1beta, TNFalpha, IL6, and IL8, and body composition
      (total, lean and fat mass in kg) by DXA at baseline, 6, and 12 months. Linear
      mixed effects models were used to examine the association between group,
      biomarkers, and body composition and whether or not changes in muscle strength or
      body composition influenced the effect of exercise on biomarkers.Results: CRP
      decreased over time among women participating in resistance training compared
      with increases in controls (P = 0.045). In stratified analyses and compared with 
      increases in controls, women who gained strength reduced CRP (P = 0.003) and
      maintained levels of IL1beta and IL6. Among exercisers who lost weight (>/=2 kg),
      CRP (P = 0.045), leptin (P < 0.01), and SAA (P = 0.029) decreased, whereas
      IGF-BP1 (P = 0.036) increased compared with controls.Conclusions: Resistance
      training may lower inflammation and improve insulin pathway profiles, but the
      magnitude and degree of benefit from exercise may depend upon whether or not
      women gained strength, a possible marker of compliance with training, and/or lost
      weight during exercise.Impact: Future resistance training trials should consider 
      these potential influencing factors as they may determine how well exercise can
      slow cancer progression and prevent disease recurrence. Cancer Epidemiol
      Biomarkers Prev; 27(2); 146-53. (c)2017 AACR.
CI  - (c)2017 American Association for Cancer Research.
FAU - Winters-Stone, Kerri M
AU  - Winters-Stone KM
AD  - Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
      wintersk@ohsu.edu.
AD  - School of Nursing, Oregon Health & Science University, Portland, Oregon.
FAU - Wood, Lisa J
AU  - Wood LJ
AD  - School of Nursing, Massachusetts General Hospital Institutes of Health
      Professions, Boston, Massachusetts.
FAU - Stoyles, Sydnee
AU  - Stoyles S
AD  - Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
AD  - School of Nursing, Oregon Health & Science University, Portland, Oregon.
FAU - Dieckmann, Nathan F
AU  - Dieckmann NF
AD  - Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
AD  - School of Nursing, Oregon Health & Science University, Portland, Oregon.
LA  - eng
SI  - ClinicalTrials.gov/NCT00665080
SI  - ClinicalTrials.gov/NCT00659906
SI  - ClinicalTrials.gov/NCT00591747
GR  - R01 NR013171/NR/NINR NIH HHS/United States
GR  - R01 NR012479/NR/NINR NIH HHS/United States
GR  - R21 CA164661/CA/NCI NIH HHS/United States
GR  - R01 CA163474/CA/NCI NIH HHS/United States
GR  - R21 HL115251/HL/NHLBI NIH HHS/United States
GR  - P30 CA069533/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20171115
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American
      Association for Cancer Research, cosponsored by the American Society of
      Preventive Oncology
JID - 9200608
PMC - PMC5811190
MID - NIHMS919452
EDAT- 2017/11/17 06:00
MHDA- 2017/11/17 06:00
CRDT- 2017/11/17 06:00
PMCR- 2019/02/01 00:00
PHST- 2017/08/22 00:00 [received]
PHST- 2017/10/05 00:00 [revised]
PHST- 2017/11/02 00:00 [accepted]
PHST- 2019/02/01 00:00 [pmc-release]
PHST- 2017/11/17 06:00 [pubmed]
PHST- 2017/11/17 06:00 [medline]
PHST- 2017/11/17 06:00 [entrez]
AID - 1055-9965.EPI-17-0766 [pii]
AID - 10.1158/1055-9965.EPI-17-0766 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2018 Feb;27(2):146-153. doi:
      10.1158/1055-9965.EPI-17-0766. Epub 2017 Nov 15.