PMID- 29140946
OWN - NLM
STAT- MEDLINE
DCOM- 20180111
LR  - 20180111
IS  - 1532-0987 (Electronic)
IS  - 0891-3668 (Linking)
VI  - 36
IP  - 12
DP  - 2017 Dec
TI  - Comparison of the QuantiFERON TB Gold In-tube Assay With Tuberculin Skin Test for
      the Diagnosis of Latent Tuberculosis Infection Among HIV-infected and Uninfected 
      Children.
PG  - e317-e321
LID - 10.1097/INF.0000000000001771 [doi]
AB  - BACKGROUND: Diagnosis of latent tuberculosis infection (LTBI) is facilitated by
      tuberculin skin testing (TST) or interferon-gamma release assays such as the
      QuantiFERON TB Gold In-Tube (QTF-GIT) assays. Limited data exist on the utility
      of interferon-gamma release assays in HIV-infected children, which may be falsely
      negative due to immunosuppression. METHODS: A cross-sectional study comparing TST
      to QTF-GIT for the diagnosis of suspected LTBI was performed in children in
      Tijuana, Mexico, and in San Diego, California. Concordance between TST (>/=5 mm
      for HIV infected and >/=10 mm for HIV uninfected) and QTF-GIT was evaluated
      utilizing kappa coefficients. Multivariate logistic regression assessed factors
      influencing the results. RESULTS: One hundred sixty-five children (70 HIV
      infected and 95 HIV uninfected) were evaluated (median age, 8.0 years). Among
      HIV-infected children, the median CD4 cell count was 913 cells/muL, with 92.9% of
      subjects on antiretroviral treatment and 80.0% with an HIV RNA load <400
      copies/mL (76% <50 copies/mL). Among HIV-infected children with no history of
      tuberculosis, 12 HIV had either a positive QTF-GIT or TST >/= 5 mm or both,
      giving a suspected LTBI prevalence of 20.3% (compared with 61.3% among
      HIV-uninfected children). Moderate concordance was demonstrated in HIV-infected
      children (both tests positive, kappa = 0.42; 95% confidence interval: 8.9%-75.4%)
      and HIV-uninfected children (both tests positive, kappa = 0.59; 95% confidence
      interval: 43.0%-76.5%). CONCLUSIONS: A moderate correlation exists between TST
      and QTF-GIT among HIV-infected and uninfected children with preserved immune
      function in an area of moderate tuberculosis endemicity.
FAU - Dehority, Walter
AU  - Dehority W
AD  - From the *Department of Pediatrics, Division of Infectious Diseases, the
      University of New Mexico Health Sciences Center, daggerDepartment of Pediatrics, 
      Division of Infectious Diseases, Center for AIDS Research, Rady Children's
      Hospital-San Diego, double daggerDepartment of Family and Preventive Medicine,
      the University of California San Diego School of Medicine, and section
      signDepartment of Pediatrics, Tijuana General Hospital, Tijuana, Mexico.
FAU - Viani, Rolando M
AU  - Viani RM
FAU - Araneta, Maria Rosario G
AU  - Araneta MRG
FAU - Lopez, Graciano
AU  - Lopez G
FAU - Spector, Stephen A
AU  - Spector SA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
SB  - IM
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/*complications
MH  - Humans
MH  - Interferon-gamma Release Tests/*statistics & numerical data
MH  - Latent Tuberculosis/*complications/*diagnosis
MH  - Male
MH  - Reproducibility of Results
MH  - Tuberculin Test/*statistics & numerical data
EDAT- 2017/11/16 06:00
MHDA- 2018/01/13 06:00
CRDT- 2017/11/16 06:00
PHST- 2017/11/16 06:00 [entrez]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
AID - 10.1097/INF.0000000000001771 [doi]
AID - 00006454-201712000-00016 [pii]
PST - ppublish
SO  - Pediatr Infect Dis J. 2017 Dec;36(12):e317-e321. doi:
      10.1097/INF.0000000000001771.