PMID- 29140874
OWN - NLM
STAT- In-Data-Review
LR  - 20180417
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 77
IP  - 3
DP  - 2018 Mar 1
TI  - HIV and Age Do Not Synergistically Affect Age-Related T-Cell Markers.
PG  - 337-344
LID - 10.1097/QAI.0000000000001595 [doi]
AB  - INTRODUCTION: Despite major progress in controlling HIV disease through
      antiretroviral therapy, changes in immune phenotype and function persist in
      individuals with chronic HIV, raising questions about accelerated aging of the
      immune system. METHODS: We conducted a cross-sectional study (2005-2007) of
      HIV-infected (n = 111) and uninfected (n = 114) men from the Veterans Aging
      Cohort Study. All HIV-infected subjects were on antiretroviral therapy with VL
      <400 copies/mL for at least 3 years. T-cell markers were examined using flow
      cytometry. We evaluated the impact of HIV serostatus and age on T-cell phenotypes
      (expressed as percentages of the total CD4 and CD8 T-cell population) using
      multivariate linear regression, adjusted for smoking, alcohol, and
      race/ethnicity. We tested for interactions between HIV and age by including
      interaction terms. RESULTS: Among both HIV-infected and uninfected subjects,
      increasing age was associated with a decreased proportion of naive CD4 T cells (P
      = 0.014) and CD8 T cells (P < 0.0001). Both HIV infection and increasing age were
      associated with higher proportions of effector memory CD4 T cells (P < 0.0001 for
      HIV; P = 0.04 for age) and CD8 T cells (P = 0.0001 for HIV; P = 0.0004 for age). 
      HIV infection, but not age, was associated with a higher proportion of activated 
      CD8 T cells (P < 0.0001). For all T-cell subsets tested, there were no
      significant interactions between HIV infection and age. CONCLUSIONS: Age and HIV 
      status independently altered the immune system, but we found no conclusive
      evidence that HIV infection and advancing age synergistically result in
      accelerated changes in age-associated T-cell markers among virally suppressed
      individuals.
FAU - Farhadian, Shelli
AU  - Farhadian S
AD  - Department of Medicine, Section of Infectious Diseases, Yale University, School
      of Medicine, New Haven, CT.
FAU - Jalbert, Emilie
AU  - Jalbert E
AD  - Department of Medicine, Division of Experimental Medicine, University of
      California, San Francisco, CA.
AD  - Currently, Division of Infectious Disease, University of Colorado, Denver, CO.
FAU - Deng, Yanhong
AU  - Deng Y
AD  - Center for Analytical Sciences, Yale University School of Public Health, New
      Haven, CT.
FAU - Goetz, Matthew B
AU  - Goetz MB
AD  - Department of Medicine, David Geffen School of Medicine, University of
      California, Los Angeles, CA.
AD  - Division of Infectious Diseases, Veterans Affairs Greater Los Angeles Health Care
      System, Los Angeles, CA.
FAU - Park, Lesley S
AU  - Park LS
AD  - Center for Population Health Sciences, Stanford University School of Medicine,
      Stanford, CA.
FAU - Justice, Amy C
AU  - Justice AC
AD  - Department of Medicine, Section of Infectious Diseases, Yale University, School
      of Medicine, New Haven, CT.
AD  - Department of Medicine, Section of Infectious Diseases, Yale University, School
      of Medicine, New Haven, CT.
AD  - Department of Medicine, Division of Experimental Medicine, University of
      California, San Francisco, CA.
AD  - Department of Medicine, Division of Experimental Medicine, University of
      California, San Francisco, CA.
FAU - Dubrow, Robert
AU  - Dubrow R
AD  - Currently, Division of Infectious Disease, University of Colorado, Denver, CO.
AD  - Currently, Division of Infectious Disease, University of Colorado, Denver, CO.
FAU - Emu, Brinda
AU  - Emu B
AD  - Department of Medicine, Section of Infectious Diseases, Yale University, School
      of Medicine, New Haven, CT.
LA  - eng
GR  - K23 AI062279/AI/NIAID NIH HHS/United States
GR  - T32 AG019134/AG/NIA NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
PMC - PMC5807137
MID - NIHMS919466
EDAT- 2017/11/16 06:00
MHDA- 2017/11/16 06:00
CRDT- 2017/11/16 06:00
PMCR- 2019/03/01 00:00
PHST- 2019/03/01 00:00 [pmc-release]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2017/11/16 06:00 [medline]
PHST- 2017/11/16 06:00 [entrez]
AID - 10.1097/QAI.0000000000001595 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2018 Mar 1;77(3):337-344. doi:
      10.1097/QAI.0000000000001595.