PMID- 29135581
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20180716
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 32
IP  - 2
DP  - 2018 Jan 14
TI  - High rates of hypertension, diabetes, elevated low-density lipoprotein
      cholesterol, and cardiovascular disease risk factors in HIV-infected patients in 
      Malawi.
PG  - 253-260
LID - 10.1097/QAD.0000000000001700 [doi]
AB  - OBJECTIVES: Data on cardiovascular disease risks among HIV-infected patients
      taking antiretroviral therapy (ART) over long periods of time are lacking in
      Sub-Saharan Africa. METHODS: A cross-sectional study was conducted in Chiradzulu,
      Malawi from December 2015 to June 2016. HIV-infected persons on ART for more than
      10 years (patients) and HIV-negative individuals (controls) from selected clinics
      participated. Following informed consent, a standardized questionnaire, clinical 
      and laboratory examinations were performed. The prevalence of cardiovascular
      disease risk factors was calculated and stratified by age group. RESULTS:
      Overall, 379 HIV-infected patients and 356 controls participated. Median time on 
      ART among patients was 11.6 years (interquartile range 10.6-12.4).Within the
      30-44, 45-59, and at least 60-year age groups, respectively, the prevalence of
      hypertension was 10.8, 20.4, and 44.7% among patients and 6.1, 25.8, and 42.9%
      among controls. Hypertension was previously undiagnosed in 60.3% patients and
      37.0% controls with elevated blood pressure. The prevalence of diabetes within
      the respective age groups was 5.0, 6.4, and 13.2% among patients, and 3.4, 4.2,
      and 1.7% among controls. HIV-infected patients were more likely to have an
      glycated hemoglobin at least 6.0% (adjusted odds ratio 1.9; 95% confidence
      interval 1.1-3.2, P = 0.02). Prevalence of low-density lipoprotein cholesterol
      more than 130 mg/dl within the respective age groups was 8.0, 15.4, and 23.7%
      among patients and 1.8, 12.5, and 11.8% among controls. CONCLUSION:
      Noncommunicable diseases were a significant burden in Malawi, with high
      prevalence of hypercholesterolemia in all survey participants and an especially
      acute diabetes burden among older HIV infected. Hypertension screening and
      treatment services are needed among identified high-risk groups to cover unmet
      needs.
FAU - Mathabire Rucker, Sekai C
AU  - Mathabire Rucker SC
AD  - Medecins Sans Frontieres, Chiradzulu.
FAU - Tayea, Alia
AU  - Tayea A
AD  - Medecins Sans Frontieres, Chiradzulu.
FAU - Bitilinyu-Bangoh, Joseph
AU  - Bitilinyu-Bangoh J
AD  - Queen Elizabeth Central Hospital, Blantyre, Malawi.
FAU - Bermudez-Aza, Elkin H
AU  - Bermudez-Aza EH
AD  - Medecins Sans Frontieres, Chiradzulu.
FAU - Salumu, Leon
AU  - Salumu L
AD  - Medecins sans Frontieres, Paris, France.
FAU - Quiles, Isabel Amoros
AU  - Quiles IA
AD  - Medecins sans Frontieres, Lilongwe.
FAU - Szumilin, Elisabeth
AU  - Szumilin E
AD  - Medecins sans Frontieres, Paris, France.
FAU - Chirwa, Zengani
AU  - Chirwa Z
AD  - HIV and AIDS Department, Ministry of Health Malawi, Lilongwe, Malawi.
FAU - Rick, Fernanda
AU  - Rick F
AD  - Medecins Sans Frontieres, Chiradzulu.
FAU - Maman, David
AU  - Maman D
AD  - Epicentre, Paris, France.
LA  - eng
PT  - Journal Article
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (Cholesterol, LDL)
SB  - IM
SB  - X
MH  - Adult
MH  - Cardiovascular Diseases/*epidemiology
MH  - Cholesterol, LDL/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus/*epidemiology
MH  - Female
MH  - HIV Infections/*complications
MH  - Humans
MH  - Hypercholesterolemia/complications/*epidemiology
MH  - Hypertension/complications/*epidemiology
MH  - Malawi/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
PMC - PMC5757671
EDAT- 2017/11/15 06:00
MHDA- 2018/07/17 06:00
CRDT- 2017/11/15 06:00
PHST- 2017/11/15 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2017/11/15 06:00 [entrez]
AID - 10.1097/QAD.0000000000001700 [doi]
PST - ppublish
SO  - AIDS. 2018 Jan 14;32(2):253-260. doi: 10.1097/QAD.0000000000001700.