PMID- 29134274
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20181113
IS  - 1432-1262 (Electronic)
IS  - 0179-1958 (Linking)
VI  - 33
IP  - 1
DP  - 2018 Jan
TI  - Harvest of lymph nodes in colorectal cancer depends on demographic and clinical
      characteristics of the patients.
PG  - 19-22
LID - 10.1007/s00384-017-2927-0 [doi]
AB  - PURPOSE: This study aims to study the impact of clinical factors on the lymph
      node sampling in a large cohort of patients with colorectal cancer. METHODS: A
      colorectal cancer database of 2298 patients in Queensland, Australia, was
      established. Zero-inflated regression method was used to model positive lymph
      node counts given the number of lymph nodes examined, with patient's demographic 
      and clinical factors as covariates in the model. Sensitivity and survival
      analyses were performed to illustrate the applicability of the recommendation of 
      the minimum number of lymph nodes need to be pathologically examined. RESULTS:
      Younger patients with a larger sized tumour located at the left colon or rectum
      require fewer lymph nodes to be pathologically examined. Overall, 45.9% of the
      patients require eight or nine lymph nodes and 31.5% needs ten or 11 lymph nodes 
      to be harvested for pathological examination. A simple formula could be used to
      obtain the minimum number of lymph node sampling required in patients with
      colorectal cancer based on patients' age as well as site and dimension of the
      cancer. CONCLUSIONS: The findings provide practical information about that the
      minimum number of lymph nodes that could be harvested at the time of collection
      of lymph nodes for pathological examination for patients with colorectal cancer. 
      The minimum number of lymph nodes harvested depends on demographic (age) and
      clinical (location and dimension of cancer) characteristics of the patients with 
      colorectal cancer.
FAU - Ng, Shu-Kay
AU  - Ng SK
AD  - School of Medicine, Griffith Medical School, Griffith University, Gold Coast,
      QLD, 4222, Australia.
FAU - Lu, Cu-Tai
AU  - Lu CT
AD  - Department of Surgery, Gold Coast Hospital, Gold Coast, QLD, Australia.
FAU - Pakneshan, Sahar
AU  - Pakneshan S
AD  - School of Medicine, Griffith Medical School, Griffith University, Gold Coast,
      QLD, 4222, Australia.
FAU - Leung, Melissa
AU  - Leung M
AD  - School of Medicine, Griffith Medical School, Griffith University, Gold Coast,
      QLD, 4222, Australia.
FAU - Siu, Simon
AU  - Siu S
AD  - School of Medicine, Griffith Medical School, Griffith University, Gold Coast,
      QLD, 4222, Australia.
FAU - Lam, Alfred King-Yin
AU  - Lam AK
AD  - School of Medicine, Griffith Medical School, Griffith University, Gold Coast,
      QLD, 4222, Australia. a.lam@griffith.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20171113
PL  - Germany
TA  - Int J Colorectal Dis
JT  - International journal of colorectal disease
JID - 8607899
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Colorectal Neoplasms/*pathology
MH  - *Demography
MH  - Female
MH  - Humans
MH  - Lymph Nodes/*pathology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - Adenocarcinoma
OT  - Colorectal cancer
OT  - Harvest
OT  - Lymph node
OT  - Pathology
EDAT- 2017/11/15 06:00
MHDA- 2018/07/28 06:00
CRDT- 2017/11/15 06:00
PHST- 2017/10/22 00:00 [accepted]
PHST- 2017/11/15 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/11/15 06:00 [entrez]
AID - 10.1007/s00384-017-2927-0 [doi]
AID - 10.1007/s00384-017-2927-0 [pii]
PST - ppublish
SO  - Int J Colorectal Dis. 2018 Jan;33(1):19-22. doi: 10.1007/s00384-017-2927-0. Epub 
      2017 Nov 13.