PMID- 29129842
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20181113
IS  - 2186-1005 (Electronic)
IS  - 1341-1098 (Linking)
VI  - 24
IP  - 1
DP  - 2018 Feb 20
TI  - Association of Perioperative Redox Balance on Long-Term Outcome in Patients
      Undergoing Lung Resection.
PG  - 13-18
LID - 10.5761/atcs.oa.17-00127 [doi]
AB  - PURPOSE: We examined whether redox balance during the perioperative period is
      associated with long-term survival of patients after undergoing lung resection.
      METHODS: Patients who underwent surgery for lung cancer from January to June 2013
      at our institution were investigated. Serum was collected during the operation,
      and on postoperative day (POD) 3 and 7, and the levels of derivatives of reactive
      oxygen metabolites (d-ROMs) and biologic antioxidant potential (BAP) were
      measured. RESULTS: In all, 21 patients (69 +/- 7 years old) were enrolled, of
      whom 9 underwent video-assisted thoracoscopic surgery. Comorbidities in the
      patients included chronic obstructive pulmonary disease in eight and idiopathic
      pulmonary fibrosis in five. d-ROM values on POD 3 and 7 were significantly
      increased as compared to those obtained during the operation (p <0.001), whereas 
      BAP did not change after surgery. Patients with a value below a d-ROM cutoff
      value of 327 during the operation showed significantly superior 3-year overall
      survival as compared to those with a value above the cutoff (87.5% vs. 20.0%, p
      <0.001). CONCLUSION: In the present patients, surgical stress caused an increase 
      in d-ROM during the postoperative course. The d-ROM value obtained during the
      operation was correlated with long-term survival following resection for lung
      cancer.
FAU - Araki, Osamu
AU  - Araki O
AD  - Department of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi,
      Japan.
FAU - Matsumura, Yuji
AU  - Matsumura Y
AD  - Department of Cardiothoracic Surgery, Dokkyo Koshigaya Hospital, Koshigaya,
      Saitama, Japan.
FAU - Inoue, Takashi
AU  - Inoue T
AD  - Department of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi,
      Japan.
FAU - Karube, Yoko
AU  - Karube Y
AD  - Department of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi,
      Japan.
FAU - Maeda, Sumiko
AU  - Maeda S
AD  - Department of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi,
      Japan.
FAU - Kobayashi, Satoru
AU  - Kobayashi S
AD  - Department of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi,
      Japan.
FAU - Chida, Masayuki
AU  - Chida M
AD  - Department of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi,
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20171110
PL  - Japan
TA  - Ann Thorac Cardiovasc Surg
JT  - Annals of thoracic and cardiovascular surgery : official journal of the
      Association of Thoracic and Cardiovascular Surgeons of Asia
JID - 9703158
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Aged
MH  - Antioxidants/metabolism
MH  - Biomarkers/blood
MH  - Carcinoma, Non-Small-Cell Lung/blood/mortality/pathology/*surgery
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/blood/mortality/pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Perioperative Period
MH  - *Pneumonectomy/adverse effects/methods/mortality
MH  - Reactive Oxygen Species/blood
MH  - Risk Factors
MH  - *Thoracic Surgery, Video-Assisted/adverse effects/mortality
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC5833135
OTO - NOTNLM
OT  - lung cancer
OT  - oxidative stress
OT  - reactive oxygen species
OT  - redox balance
EDAT- 2017/11/14 06:00
MHDA- 2018/08/28 06:00
CRDT- 2017/11/14 06:00
PHST- 2017/11/14 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2017/11/14 06:00 [entrez]
AID - 10.5761/atcs.oa.17-00127 [doi]
PST - ppublish
SO  - Ann Thorac Cardiovasc Surg. 2018 Feb 20;24(1):13-18. doi:
      10.5761/atcs.oa.17-00127. Epub 2017 Nov 10.