PMID- 29128386
OWN - NLM
STAT- In-Process
LR  - 20180414
IS  - 1097-6779 (Electronic)
IS  - 0016-5107 (Linking)
VI  - 87
IP  - 4
DP  - 2018 Apr
TI  - A pilot study of endoscopically inserted biodegradable biliary stents in the
      treatment of benign biliary strictures and cystic duct leaks.
PG  - 1132-1137
LID - S0016-5107(17)32441-0 [pii]
LID - 10.1016/j.gie.2017.10.042 [doi]
AB  - BACKGROUND AND AIMS: Self-expanding biodegradable biliary stents (BDBSs) have
      recently become available for use in endoscopic retrograde cholangiography (ERC).
      The aim was to evaluate the effectiveness and safety of novel BDBSs in iatrogenic
      cystic duct leaks and benign biliary strictures (BBSs). METHODS: Patients
      providing informed consent were recruited for the prospective study. Braided
      self-expanding poly-dioxanone BDBSs were inserted using ERC during from 2014 to
      2016. Repeated liver function tests and magnetic resonance imaging were performed
      during follow-up. The main outcomes were treatment success and adverse events.
      RESULTS: Thirteen patients, 5 women, median age 67 years (range, 43-79) underwent
      BDBS insertion for iatrogenic cystic duct leak (n = 7) or BBS (n = 6). Stent
      insertion using ERC was successful in all cases. All bile leaks were treated
      uneventfully with BDBSs. In BBSs, the clinical success rate of BDBS therapy was
      83% in a median of 21 months of follow-up (range, 14-25). Early ERC-related
      adverse events included 1 cholangitis (8%) and 1 pancreatitis (8%), both in the
      stricture group. During the first 90 days, 23% of patients were readmitted for
      mild cholangitis. CONCLUSIONS: The short- and long-term safety of endoscopically 
      inserted poly-dioxanone BDBSs was satisfactory. The management of cystic duct
      leaks and benign distal common bile duct strictures was highly successful.
      Episodes of mild cholangitis during stent indwelling seemed to be typical of
      BDBSs. The advantage of BDBSs is the avoidance of repeated endoscopy for stent
      removal. (Clinical trial registration number: NCT02353286.).
CI  - Copyright (c) 2018 American Society for Gastrointestinal Endoscopy. Published by 
      Elsevier Inc. All rights reserved.
FAU - Siiki, Antti
AU  - Siiki A
AD  - Department of Gastroenterology and Alimentary Tract Surgery, Tampere University
      Hospital, Tampere, Finland.
FAU - Rinta-Kiikka, Irina
AU  - Rinta-Kiikka I
AD  - Department of Clinical Radiology, Tampere University Hospital, Tampere, Finland.
FAU - Sand, Juhani
AU  - Sand J
AD  - Hospital District Administration, Paijat-Hame Central Hospital, Lahti, Finland;
      Medical School, University of Tampere, Tampere, Finland.
FAU - Laukkarinen, Johanna
AU  - Laukkarinen J
AD  - Department of Gastroenterology and Alimentary Tract Surgery, Tampere University
      Hospital, Tampere, Finland; Medical School, University of Tampere, Tampere,
      Finland.
LA  - eng
SI  - ClinicalTrials.gov/NCT02353286
PT  - Journal Article
DEP - 20171108
PL  - United States
TA  - Gastrointest Endosc
JT  - Gastrointestinal endoscopy
JID - 0010505
EDAT- 2017/11/13 06:00
MHDA- 2017/11/13 06:00
CRDT- 2017/11/13 06:00
PHST- 2017/08/23 00:00 [received]
PHST- 2017/10/23 00:00 [accepted]
PHST- 2017/11/13 06:00 [pubmed]
PHST- 2017/11/13 06:00 [medline]
PHST- 2017/11/13 06:00 [entrez]
AID - S0016-5107(17)32441-0 [pii]
AID - 10.1016/j.gie.2017.10.042 [doi]
PST - ppublish
SO  - Gastrointest Endosc. 2018 Apr;87(4):1132-1137. doi: 10.1016/j.gie.2017.10.042.
      Epub 2017 Nov 8.