PMID- 29126846
DCOM- 20181211
LR  - 20181211
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 112
DP  - 2018 Feb
TI  - Sexual Function and Quality of Life in Adult Male Individuals with
      Exstrophy-Epispadias Complex-a Survey of the German CURE-Network.
PG  - 215-221
LID - S0090-4295(17)31160-3 [pii]
LID - 10.1016/j.urology.2017.08.063 [doi]
AB  - OBJECTIVE: To investigate sexual function and quality of life (QoL) in adult male
      individuals with exstrophy-epispadias complex (EEC). Data from the German Network
      for Congenital Urorectal Malformations (CURE-Net) were used. PATIENTS AND
      METHODS: Fifty-one male participants (>/=18 years) recruited by CURE-Net between 
      2009 and 2012 were re-contacted per mail and asked to fill out 4 questionnaires
      including International Index of Erectile Function (IIEF-5), Cologne Assessment
      of Erectile Dysfunction (KEED), the Short-Form 36 (SF-36), and one self-designed 
      questionnaire about their medical history, current health status, and sexual
      experience. The SF-36 results were compared with general German population.
      RESULTS: Nineteen male participants (37%) completed all questionnaires (median
      age 26 years, 84% classical bladder exstrophy). The majority (68%) was
      reconstructed in a staged or single-staged approach; further 32% had a primary
      urinary diversion. Seventy-four percent of the participants reported a certain
      degree of urinary incontinence. Mean IIEF-15 results showed mild to moderate or
      moderate impairment in all domains. The SF-36 results revealed no difference in
      the German population. Subgroup analysis showed statistically significant lower
      results in certain SF-36 domains with regard to incontinence, dissatisfaction
      with genital appearance, and antihypertensive drug intake. CONCLUSION: Although
      there is no difference in overall QoL comparing male individuals with EEC to the 
      general German population, incontinence, dissatisfaction with genital appearance,
      and taking antihypertensive medication seem to have a considerable impact on QoL.
      Furthermore, mild to moderate erectile dysfunction and moderate intercourse
      satisfaction were confirmed, suggesting the need for further improvement in care 
      for adult male individuals with EEC.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Traceviciute, Justina
AU  - Traceviciute J
AD  - Department of Urology, University Medical Center Gottingen, Gottingen, Germany.
      Electronic address:
FAU - Zwink, Nadine
AU  - Zwink N
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research
      Center, Heidelberg, Germany; Department for Child and Adolescent Psychiatry,
      Johannes Gutenberg-University, Mainz, Germany.
FAU - Jenetzky, Ekkehart
AU  - Jenetzky E
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research
      Center, Heidelberg, Germany; Department for Child and Adolescent Psychiatry,
      Johannes Gutenberg-University, Mainz, Germany; Child Center Maulbronn, Hospital
      for Paediatric Neurology and Social Paediatrics, Maulbronn, Germany.
FAU - Reutter, Heiko
AU  - Reutter H
AD  - Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of
      Neonatology, Children's Hospital, University of Bonn, Bonn, Germany.
FAU - Hirsch, Karin
AU  - Hirsch K
AD  - Department of Paediatric Urology, University Hospital Erlangen, Erlangen,
FAU - Stein, Raimund
AU  - Stein R
AD  - Department of Paediatric and Adolescent Urology, University of Mannheim,
      Mannheim, Germany.
FAU - Rosch, Wolfgang H
AU  - Rosch WH
AD  - Department of Paediatric Urology, Clinic St. Hedwig, University Medical Center
      Regensburg, Regensburg, Germany.
FAU - Ebert, Anne-Karoline
AU  - Ebert AK
AD  - Department of Urology and Paediatric Urology, Ulm University, Ulm, Germany.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20171107
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
RN  - Bladder Exstrophy and Epispadias Complex
SB  - IM
CIN - Urology. 2018 Feb;112:221. PMID: 29249460
MH  - Adult
MH  - Bladder Exstrophy/*complications/physiopathology
MH  - Diagnostic Self Evaluation
MH  - Epispadias/*complications/physiopathology
MH  - Erectile Dysfunction/*etiology
MH  - Germany
MH  - Humans
MH  - Male
MH  - Penile Erection
MH  - *Quality of Life
MH  - Sexual Dysfunction, Physiological/etiology
MH  - Young Adult
EDAT- 2017/11/12 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/11/12 06:00
PHST- 2017/03/28 00:00 [received]
PHST- 2017/08/18 00:00 [revised]
PHST- 2017/08/29 00:00 [accepted]
PHST- 2017/11/12 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/11/12 06:00 [entrez]
AID - S0090-4295(17)31160-3 [pii]
AID - 10.1016/j.urology.2017.08.063 [doi]
PST - ppublish
SO  - Urology. 2018 Feb;112:215-221. doi: 10.1016/j.urology.2017.08.063. Epub 2017 Nov