PMID- 29121859
OWN - NLM
STAT- MEDLINE
DCOM- 20180619
LR  - 20181202
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Nov 9
TI  - Alterations in PGC1alpha expression levels are involved in colorectal cancer
      risk: a qualitative systematic review.
PG  - 731
LID - 10.1186/s12885-017-3725-3 [doi]
AB  - BACKGROUND: Colorectal cancer (CRC) is a major global public health problem and
      the second leading cause of cancer-related death. Mitochondrial dysfunction has
      long been suspected to be involved in this type of tumorigenesis, as supported by
      an accumulating body of research evidence. However, little is known about how
      mitochondrial alterations contribute to tumorigenesis. Mitochondrial biogenesis
      is a fundamental cellular process required to maintain functional mitochondria
      and as an adaptive mechanism in response to changing energy requirements.
      Mitochondrial biogenesis is regulated by peroxisome proliferator-activated
      receptor gamma coactivator 1-alpha (PPARGC1A or PGC1alpha). In this paper, we
      report a systematic review to summarize current evidence on the role of PGC1alpha
      in the initiation and progression of CRC. The aim is to provide a basis for more 
      comprehensive research. METHODS: The literature search, data extraction and
      quality assessment were performed according to the document Guidance on the
      Conduct of Narrative Synthesis in Systematic Reviews and the PRISMA declaration. 
      RESULTS: The studies included in this review aimed to evaluate whether increased 
      or decreased PGC1alpha expression affects the development of CRC. Each article
      proposes a possible molecular mechanism of action and we create two concept maps.
      CONCLUSION: Our systematic review indicates that altered expression of PGC1alpha 
      modifies CRC risk. Most studies showed that overexpression of this gene increases
      CRC risk, while some studies indicated that lower than normal expression levels
      could increase CRC risk. Thus, various authors propose PGC1alpha as a good
      candidate molecular target for cancer therapy. Reducing expression of this gene
      could help to reduce risk or progression of CRC.
FAU - Alonso-Molero, Jessica
AU  - Alonso-Molero J
AUID- ORCID: http://orcid.org/0000-0003-0965-1291
AD  - Grupo de Investigacion en Interacciones Gen-Ambiente y Salud, Universidad de
      Leon, Leon, Spain. jalonm00@estudiantes.unileon.es.
AD  - Universidad de Cantabria, Santander, Spain. jalonm00@estudiantes.unileon.es.
AD  - Departamento Medicina Preventiva y Salud Publica, Facultad Ciencias de la Salud, 
      Campus Vegazana, s/n. Leon, C.P.: 24071, Castilla y Leon, Spain.
      jalonm00@estudiantes.unileon.es.
FAU - Gonzalez-Donquiles, Carmen
AU  - Gonzalez-Donquiles C
AD  - Grupo de Investigacion en Interacciones Gen-Ambiente y Salud, Universidad de
      Leon, Leon, Spain.
FAU - Fernandez-Villa, Tania
AU  - Fernandez-Villa T
AD  - Grupo de Investigacion en Interacciones Gen-Ambiente y Salud, Universidad de
      Leon, Leon, Spain.
FAU - de Souza-Teixeira, Fernanda
AU  - de Souza-Teixeira F
AD  - Grupo de Investigacion en Interacciones Gen-Ambiente y Salud, Universidad de
      Leon, Leon, Spain.
AD  - Superior Physical Education School, Federal University of Pelotas, Pelotas,
      Brazil.
FAU - Vilorio-Marques, Laura
AU  - Vilorio-Marques L
AD  - Grupo de Investigacion en Interacciones Gen-Ambiente y Salud, Universidad de
      Leon, Leon, Spain.
FAU - Molina, Antonio J
AU  - Molina AJ
AD  - Grupo de Investigacion en Interacciones Gen-Ambiente y Salud, Universidad de
      Leon, Leon, Spain.
FAU - Martin, Vicente
AU  - Martin V
AD  - Grupo de Investigacion en Interacciones Gen-Ambiente y Salud, Universidad de
      Leon, Leon, Spain.
AD  - CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20171109
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
SB  - IM
MH  - Animals
MH  - Carcinogenesis/metabolism
MH  - Colorectal Neoplasms/diagnosis/genetics/*metabolism
MH  - *Evaluation Studies as Topic
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator
      1-alpha/*biosynthesis/genetics
MH  - Risk Factors
PMC - PMC5679491
OTO - NOTNLM
OT  - Colorectal cancer (CRC)
OT  - Molecular mechanism
OT  - PGC1alpha or PPARGC1alpha
OT  - Signaling or metabolic pathways
EDAT- 2017/11/11 06:00
MHDA- 2018/06/21 06:00
CRDT- 2017/11/11 06:00
PHST- 2016/11/29 00:00 [received]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2017/11/11 06:00 [entrez]
PHST- 2017/11/11 06:00 [pubmed]
PHST- 2018/06/21 06:00 [medline]
AID - 10.1186/s12885-017-3725-3 [doi]
AID - 10.1186/s12885-017-3725-3 [pii]
PST - epublish
SO  - BMC Cancer. 2017 Nov 9;17(1):731. doi: 10.1186/s12885-017-3725-3.