PMID- 29112981
OWN - NLM
STAT- MEDLINE
DCOM- 20171128
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 11
DP  - 2017
TI  - Adjustment of the dynamic weight distribution as a sensitive parameter for
      diagnosis of postural alteration in a rodent model of vestibular deficit.
PG  - e0187472
LID - 10.1371/journal.pone.0187472 [doi]
AB  - Vestibular disorders, by inducing significant posturo-locomotor and cognitive
      disorders, can significantly impair the most basic tasks of everyday life. Their 
      precise diagnosis is essential to implement appropriate therapeutic
      countermeasures. Monitoring their evolution is also very important to validate
      or, on the contrary, to adapt the undertaken therapeutic actions. To date, the
      diagnosis methods of posturo-locomotor impairments are restricted to examinations
      that most often lack sensitivity and precision. In the present work we studied
      the alterations of the dynamic weight distribution in a rodent model of sudden
      and complete unilateral vestibular loss. We used a system of force sensors
      connected to a data analysis system to quantify in real time and in an automated 
      way the weight bearing of the animal on the ground. We show here that sudden,
      unilateral, complete and permanent loss of the vestibular inputs causes a severe 
      alteration of the dynamic ground weight distribution of vestibulo lesioned
      rodents. Characteristics of alterations in the dynamic weight distribution vary
      over time and follow the sequence of appearance and disappearance of the various 
      symptoms that compose the vestibular syndrome. This study reveals for the first
      time that dynamic weight bearing is a very sensitive parameter for evaluating
      posturo-locomotor function impairment. Associated with more classical vestibular 
      examinations, this paradigm can considerably enrich the methods for assessing and
      monitoring vestibular disorders. Systematic application of this type of
      evaluation to the dizzy or unstable patient could improve the detection of
      vestibular deficits and allow predicting better their impact on posture and walk.
      Thus it could also allow a better follow-up of the therapeutic approaches for
      rehabilitating gait and balance.
FAU - Tighilet, Brahim
AU  - Tighilet B
AD  - Aix Marseille Universite, CNRS, Integrative and Adaptative Neurosciences UMR
      7260, Team Pathophysiology and Therapy of Vestibular Disorders, Marseille,
      France.
FAU - Pericat, David
AU  - Pericat D
AD  - Aix Marseille Universite, CNRS, Integrative and Adaptative Neurosciences UMR
      7260, Team Pathophysiology and Therapy of Vestibular Disorders, Marseille,
      France.
FAU - Frelat, Alais
AU  - Frelat A
AD  - Aix Marseille Universite, CNRS, Integrative and Adaptative Neurosciences UMR
      7260, Team Pathophysiology and Therapy of Vestibular Disorders, Marseille,
      France.
FAU - Cazals, Yves
AU  - Cazals Y
AD  - Aix Marseille Universite, CNRS, Integrative and Adaptative Neurosciences UMR
      7260, Team Pathophysiology and Therapy of Vestibular Disorders, Marseille,
      France.
FAU - Rastoldo, Guillaume
AU  - Rastoldo G
AD  - Aix Marseille Universite, CNRS, Integrative and Adaptative Neurosciences UMR
      7260, Team Pathophysiology and Therapy of Vestibular Disorders, Marseille,
      France.
FAU - Boyer, Florent
AU  - Boyer F
AD  - Aix Marseille Universite, CNRS, Integrative and Adaptative Neurosciences UMR
      7260, Team Pathophysiology and Therapy of Vestibular Disorders, Marseille,
      France.
FAU - Dumas, Olivier
AU  - Dumas O
AD  - Aix Marseille Universite, CNRS, Integrative and Adaptative Neurosciences UMR
      7260, Team Pathophysiology and Therapy of Vestibular Disorders, Marseille,
      France.
FAU - Chabbert, Christian
AU  - Chabbert C
AUID- ORCID: http://orcid.org/0000-0003-3932-0223
AD  - Aix Marseille Universite, CNRS, Integrative and Adaptative Neurosciences UMR
      7260, Team Pathophysiology and Therapy of Vestibular Disorders, Marseille,
      France.
LA  - eng
PT  - Journal Article
DEP - 20171107
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Gait
MH  - Male
MH  - *Postural Balance
MH  - Rats
MH  - Rats, Long-Evans
MH  - Vestibular Diseases/*physiopathology
PMC - PMC5675415
EDAT- 2017/11/08 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/11/08 06:00
PHST- 2017/05/30 00:00 [received]
PHST- 2017/10/20 00:00 [accepted]
PHST- 2017/11/08 06:00 [entrez]
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 10.1371/journal.pone.0187472 [doi]
AID - PONE-D-17-20622 [pii]
PST - epublish
SO  - PLoS One. 2017 Nov 7;12(11):e0187472. doi: 10.1371/journal.pone.0187472.
      eCollection 2017.