PMID- 29112111
OWN - NLM
STAT- MEDLINE
DCOM- 20180907
LR  - 20180907
IS  - 1535-1815 (Electronic)
IS  - 0749-5161 (Linking)
VI  - 34
IP  - 6
DP  - 2018 Jun
TI  - Pediatric Minoxidil Exposures Reported to Texas Poison Centers.
PG  - 413-416
LID - 10.1097/PEC.0000000000001226 [doi]
AB  - OBJECTIVES: It has been suggested that ingestion of even small amounts of
      minoxidil by young children may result in serious adverse effects. The intent of 
      this study was to describe pediatric minoxidil exposures reported to a statewide 
      poison center system. METHODS: Cases were minoxidil exposures among patients 5
      years or younger reported to Texas poison centers during 2000 to 2014. The
      distribution by various demographic and clinical factors was determined. RESULTS:
      Of 125 total cases, 58% were male and 78% aged 1 to 2 years. Ingestion alone was 
      reported in 92% of the exposures. Ninety-eight percent of the exposures were
      unintentional, and 94% occurred at the patient's own residence. Sixty-two percent
      of the patients were managed on site. The outcome was not serious (no effect,
      minor effect, not followed [nontoxic], not followed [minimal effects]) in 88% of 
      the exposures. The most common adverse effect was vomiting, reported in 8% of the
      exposures. The most common treatments were dilution/irrigation/wash (53%),
      activated charcoal (18%), food/snack (17%), and intravenous fluids (8%).
      CONCLUSIONS: Few pediatric minoxidil exposures were reported to Texas poison
      centers. Of these exposures, most involved ingestion, were unintentional, and
      involved patients who were male and aged 1 to 2 years. Although it has been
      suggested that pediatric minoxidil ingestions might result in serious adverse
      effects, this study suggests that most pediatric minoxidil exposures reported to 
      poison centers are not likely to have serious outcomes and may be managed at
      home.
FAU - Forrester, Mathias B
AU  - Forrester MB
AD  - From the Environmental Epidemiology and Disease Registries Section, Department of
      State Health Services, Austin, TX.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Emerg Care
JT  - Pediatric emergency care
JID - 8507560
RN  - 0 (Antihypertensive Agents)
RN  - 5965120SH1 (Minoxidil)
SB  - IM
MH  - Antihypertensive Agents/*poisoning
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Minoxidil/*poisoning
MH  - Poison Control Centers/*statistics & numerical data
MH  - Retrospective Studies
MH  - Texas/epidemiology
EDAT- 2017/11/08 06:00
MHDA- 2018/09/08 06:00
CRDT- 2017/11/08 06:00
PHST- 2017/11/08 06:00 [pubmed]
PHST- 2018/09/08 06:00 [medline]
PHST- 2017/11/08 06:00 [entrez]
AID - 10.1097/PEC.0000000000001226 [doi]
PST - ppublish
SO  - Pediatr Emerg Care. 2018 Jun;34(6):413-416. doi: 10.1097/PEC.0000000000001226.