PMID- 29107108
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20180416
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 413
DP  - 2018 Jan 28
TI  - Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid
      endometrial carcinoma through inactivating neuromedin U.
PG  - 23-34
LID - S0304-3835(17)30665-1 [pii]
LID - 10.1016/j.canlet.2017.10.028 [doi]
AB  - Endometrioid endometrial carcinoma (EEC) is one of the common causes of
      cancer-related mortality in women. Mounting evidences suggest that long noncoding
      RNAs (lncRNAs) function in multiple cancers. In this study, we discovered that
      HAND2-AS1, a lncRNA transcribed antisense adjacent to Heart and Neural Crest
      Derivatives Expressed 2 (HAND2) in chromosome 4q33-34, is significantly
      down-regulated in EEC. HAND2-AS1 and HAND2 were frequently down-regulated in EEC 
      tissues, especially in poor differentiated tumor tissues. Down-regulation of
      HAND2-AS1 and HAND2 was correlated with tumor grade, lymph node metastasis and
      recurrence of EEC patients. HAND2-AS1 and HAND2 were co-downregulated by promoter
      DNA hypermethylation in EEC. Overexpression of HAND2-AS1 in EEC cells
      demonstrated that HAND2-AS1 suppressed migration and invasion of EEC cells.
      Similarly, overexpression of HAND2 also inhibited migration and invasion EEC
      cells indicating that HAND2-AS1 and HAND2 had a concordant role in the
      progression of EEC. However, HAND2 was not regulated by HAND2-AS1 in EEC.
      Furthermore, the anti-tumorigenic effect of HAND2-AS1 was mediated by
      down-regulating NMU, which has an oncogenic role in EEC. Our findings therefore
      provide the first evidence that HAND2-AS1 is a critical tumor suppressor in EEC.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Yang, Xueying
AU  - Yang X
AD  - Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese
      University of Hong Kong, Hong Kong, China. Electronic address: yxueyang@163.com.
FAU - Wang, Chi Chiu
AU  - Wang CC
AD  - Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese
      University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health
      Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, China.
      Electronic address: ccwang@cuhk.edu.hk.
FAU - Lee, Wayne Yuk Wai
AU  - Lee WYW
AD  - Department of Orthopedics and Traumatology, Prince of Wales Hospital, The Chinese
      University of Hong Kong, Hong Kong, China. Electronic address:
      waynelee@ort.cuhk.edu.hk.
FAU - Trovik, Jone
AU  - Trovik J
AD  - Department of Gynaecology and Obstetrics, Haukeland University Hospital, Bergen, 
      Norway. Electronic address: jone.trovik@helse-bergen.no.
FAU - Chung, Tony Kwok Hung
AU  - Chung TKH
AD  - Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese
      University of Hong Kong, Hong Kong, China. Electronic address:
      tonychung@cuhk.edu.hk.
FAU - Kwong, Joseph
AU  - Kwong J
AD  - Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese
      University of Hong Kong, Hong Kong, China. Electronic address:
      josephkwong@cuhk.edu.hk.
LA  - eng
PT  - Journal Article
DEP - 20171026
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Neuropeptides)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (long non-coding RNA HAND2-AS1, human)
RN  - 117505-80-3 (neuromedin U)
SB  - IM
MH  - Carcinoma, Endometrioid/genetics/*metabolism/secondary
MH  - Cell Line, Tumor
MH  - *Cell Movement
MH  - DNA Methylation
MH  - Endometrial Neoplasms/genetics/*metabolism/pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Invasiveness
MH  - Neuropeptides/genetics/*metabolism
MH  - Promoter Regions, Genetic
MH  - RNA Interference
MH  - RNA, Long Noncoding/genetics/*metabolism
MH  - Signal Transduction
MH  - Time Factors
MH  - Transcriptome
MH  - Transfection
OTO - NOTNLM
OT  - *Endometrial carcinoma
OT  - *HAND2
OT  - *HAND2-AS1
OT  - *LncRNA
OT  - *NMU
OT  - *Promoter hypermethylation
EDAT- 2017/11/07 06:00
MHDA- 2017/12/05 06:00
CRDT- 2017/11/07 06:00
PHST- 2017/06/26 00:00 [received]
PHST- 2017/10/19 00:00 [revised]
PHST- 2017/10/19 00:00 [accepted]
PHST- 2017/11/07 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2017/11/07 06:00 [entrez]
AID - S0304-3835(17)30665-1 [pii]
AID - 10.1016/j.canlet.2017.10.028 [doi]
PST - ppublish
SO  - Cancer Lett. 2018 Jan 28;413:23-34. doi: 10.1016/j.canlet.2017.10.028. Epub 2017 
      Oct 26.