PMID- 29094364
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20181202
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 128
IP  - 6
DP  - 2018 Jun
TI  - Risk factors of pediatric tinnitus: Systematic review and meta-analysis.
PG  - 1462-1468
LID - 10.1002/lary.26924 [doi]
AB  - OBJECTIVES/HYPOTHESIS: Medications for pediatric tinnitus are not widely used due
      to a lack of evidence-based information. The modification of risk factors is
      essential in pediatric tinnitus; however, there is a lack of systematic reviews
      despite several reports on risk factors. This study performed a systematic review
      and meta-analysis of available literature to evaluate risk factors of pediatric
      tinnitus. METHODS: Studies reporting the risk factors of pediatric tinnitus were 
      systematically reviewed by searching the MEDLINE, PubMed, and Embase databases
      for studies published from database inception to 2016. The selected articles
      included clinical or epidemiological studies conducted with at least 50 subjects 
      and at least one risk factor, including age, gender, hearing loss, noise
      exposure, or smoking. RESULTS: Eleven studies involving a total of 28,358
      individuals were identified. Increased age was not a significant risk factor with
      a standardized median difference of 0.16 (95% confidence interval [CI]: -0.01 to 
      0.33). However, there was a significant correlation between increased age and
      tinnitus in the adolescent population. The odds ratio (OR) was 1.37 for female
      gender (95% CI: 1.17 to 1.60), 2.39 for hearing loss (95% CI: 1.48 to 3.87), and 
      11.35 for noise exposure (95% CI: 1.87 to 68.77). Two studies in adolescents
      showed statistical significance for smoking as a risk factor in developing
      tinnitus (OR: 6.05, 95% CI: 1.81 to 20.21). CONCLUSIONS: Older-aged adolescents, 
      as well as those who are females and those with hearing loss may have a higher
      risk of tinnitus. Noise exposure in the general pediatric population and smoking 
      in adolescents may represent especially important risk factors in pediatric
      tinnitus. Laryngoscope, 128:1462-1468, 2018.
CI  - (c) 2017 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Lee, Doh Young
AU  - Lee DY
AUID- ORCID: 0000-0003-1590-8559
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Anam
      Hospital, Seoul, South Korea.
FAU - Kim, Young Ho
AU  - Kim YH
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National
      University Boramae Medical Center, Seoul National University College of Medicine,
      Seoul, South Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20171102
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Hearing Loss/*complications
MH  - Humans
MH  - Male
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - Tinnitus/*etiology
MH  - Young Adult
OTO - NOTNLM
OT  - *Tinnitus
OT  - *age
OT  - *gender
OT  - *hearing loss
OT  - *pediatric
EDAT- 2017/11/03 06:00
MHDA- 2018/11/21 06:00
CRDT- 2017/11/03 06:00
PHST- 2017/06/07 00:00 [received]
PHST- 2017/08/21 00:00 [revised]
PHST- 2017/08/28 00:00 [accepted]
PHST- 2017/11/03 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
PHST- 2017/11/03 06:00 [entrez]
AID - 10.1002/lary.26924 [doi]
PST - ppublish
SO  - Laryngoscope. 2018 Jun;128(6):1462-1468. doi: 10.1002/lary.26924. Epub 2017 Nov
      2.