PMID- 29077588
OWN - NLM
STAT- In-Data-Review
LR  - 20180131
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 53
IP  - 3
DP  - 2018 Mar
TI  - Implementation of a 5-Minute Magnetic Resonance Imaging Screening Protocol for
      Prostate Cancer in Men With Elevated Prostate-Specific Antigen Before Biopsy.
PG  - 186-190
LID - 10.1097/RLI.0000000000000427 [doi]
AB  - PURPOSE: The aims of this study were to establish a 5-minute magnetic resonance
      (MR) screening protocol for prostate cancer in men before biopsy and to evaluate 
      effects on Prostate Imaging Reporting and Data System (PI-RADS) V2 scoring in
      comparison to a conventional, fully diagnostic multiparametric MR imaging (mpMRI)
      approach. MATERIALS AND METHODS: Fifty-two patients with elevated
      prostate-specific antigen levels and without prior biopsy were prospectively
      included in this institutional review board-approved study. In all patients, an
      mpMRI protocol according to the PI-RADS recommendations was acquired on a 3 T MRI
      system. In addition, an accelerated diffusion-weighted imaging sequence was
      acquired using simultaneous multislice technique (DW-EPISMS). Two readers
      independently evaluated the images for the presence/absence of prostate cancer
      according to the PI-RADS criteria and for additional findings. In a first reading
      session, only the screening protocol consisting of axial T2-weighted and
      DW-EPISMS images was made available. In a subsequent reading session, the mpMRI
      protocol was assessed blinded to the results of the first reading, serving as
      reference standard. RESULTS: Both readers successfully established a final
      diagnosis according to the PI-RADS criteria in the screening and mpMRI protocol. 
      Mean lesion size was 1.2 cm in the screening and 1.4 cm in the mpMRI protocol (P 
      = 0.4) with 35% (18/52) of PI-RADS IV/V lesions. Diagnostic performance of the
      screening protocol was excellent with a sensitivity and specificity of 100% for
      both readers with no significant differences in comparison to the mpMRI standard 
      (P = 1.0). In 3 patients, suspicious lymph nodes were reported as additional
      finding, which were equally detectable in the screening and mpMRI protocol.
      CONCLUSIONS: A 5-minute MR screening protocol for prostate cancer in men with
      elevated prostate-specific antigen levels before biopsy is applicable for
      clinical routine with similar diagnostic performance as the full diagnostic mpMRI
      approach.
FAU - Weiss, Jakob
AU  - Weiss J
FAU - Martirosian, Petros
AU  - Martirosian P
FAU - Notohamiprodjo, Mike
AU  - Notohamiprodjo M
FAU - Kaufmann, Sascha
AU  - Kaufmann S
FAU - Othman, Ahmed E
AU  - Othman AE
FAU - Grosse, Ulrich
AU  - Grosse U
FAU - Nikolaou, Konstantin
AU  - Nikolaou K
FAU - Gatidis, Sergios
AU  - Gatidis S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
EDAT- 2017/10/28 06:00
MHDA- 2017/10/28 06:00
CRDT- 2017/10/28 06:00
PHST- 2017/10/28 06:00 [pubmed]
PHST- 2017/10/28 06:00 [medline]
PHST- 2017/10/28 06:00 [entrez]
AID - 10.1097/RLI.0000000000000427 [doi]
PST - ppublish
SO  - Invest Radiol. 2018 Mar;53(3):186-190. doi: 10.1097/RLI.0000000000000427.