PMID- 29072790
OWN - NLM
STAT- In-Data-Review
LR  - 20180125
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Linking)
VI  - 124
IP  - 3
DP  - 2018 Feb 1
TI  - Sleep disturbance in men receiving androgen deprivation therapy for prostate
      cancer: The role of hot flashes and nocturia.
PG  - 499-506
LID - 10.1002/cncr.31024 [doi]
AB  - BACKGROUND: Patients with prostate cancer receiving androgen deprivation therapy 
      (ADT) are at risk of sleep disturbance; however, to the authors' knowledge, the
      mechanisms by which ADT may affect sleep are not well understood. The current
      study compared objective and subjective sleep disturbance in ADT recipients and
      controls and examined whether sleep disturbance in ADT recipients is attributable
      to the influence of ADT on hot flashes and nocturia. METHODS: Patients with
      prostate cancer were assessed before or within 1 month after the initiation of
      ADT as well as 6 months and 12 months later (78 patients). Patients with prostate
      cancer were treated with prostatectomy only (99 patients) and men with no history
      of cancer (108 men) were assessed at similar intervals. Participants
      self-reported their sleep disturbance (Insomnia Severity Index) and interference 
      from hot flashes (Hot Flash Related Daily Interference Scale). One hundred
      participants also wore actigraphs for 3 days at the 6-month assessment to measure
      objective sleep disturbance and reported their nocturia frequency. RESULTS: ADT
      recipients reported worse sleep disturbance, higher rates of clinically
      significant sleep disturbance, and greater hot flash interference than controls
      (Ps</=.03). In cross-sectional analyses among those with actigraphy data, ADT
      recipients had greater objective sleep disturbance and more episodes of nocturia 
      (Ps<.01). Cross-sectional mediation analyses demonstrated that the association
      between ADT and objectively and subjectively measured sleep disturbance was
      partly attributable to nocturia and hot flashes (Ps<.05). CONCLUSIONS: The
      results of the current study suggest that the association between ADT and sleep
      may be partly explained by nocturia and hot flash interference. Future studies
      should examine behavioral and pharmacologic interventions to address these
      symptoms among ADT recipients. Cancer 2018;124:499-506. (c) 2017 American Cancer 
      Society.
CI  - (c) 2017 American Cancer Society.
FAU - Gonzalez, Brian D
AU  - Gonzalez BD
AUID- ORCID: http://orcid.org/0000-0001-5108-5735
AD  - Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida.
FAU - Small, Brent J
AU  - Small BJ
AD  - School of Aging Studies, University of South Florida, Tampa, Florida.
FAU - Cases, Mallory G
AU  - Cases MG
AD  - Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida.
FAU - Williams, Noelle L
AU  - Williams NL
AD  - Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel
      Cancer Center, Philadelphia, Pennsylvania.
FAU - Fishman, Mayer N
AU  - Fishman MN
AD  - Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida.
FAU - Jacobsen, Paul B
AU  - Jacobsen PB
AD  - Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida.
FAU - Jim, Heather S L
AU  - Jim HSL
AD  - Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida.
LA  - eng
GR  - K01 CA211789/CA/NCI NIH HHS/United States
GR  - P30 CA076292/CA/NCI NIH HHS/United States
GR  - R01 CA132803/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20171026
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
PMC - PMC5780192
MID - NIHMS901673
OTO - NOTNLM
OT  - antiandrogens
OT  - hot flashes
OT  - nocturia
OT  - prostatic neoplasms
OT  - sleep
EDAT- 2017/10/27 06:00
MHDA- 2017/10/27 06:00
CRDT- 2017/10/27 06:00
PMCR- 2019/02/01 00:00
PHST- 2017/03/28 00:00 [received]
PHST- 2017/07/13 00:00 [revised]
PHST- 2017/08/15 00:00 [accepted]
PHST- 2019/02/01 00:00 [pmc-release]
PHST- 2017/10/27 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2017/10/27 06:00 [entrez]
AID - 10.1002/cncr.31024 [doi]
PST - ppublish
SO  - Cancer. 2018 Feb 1;124(3):499-506. doi: 10.1002/cncr.31024. Epub 2017 Oct 26.