PMID- 29063295
DCOM- 20190304
LR  - 20190304
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 25
IP  - 1
DP  - 2018 Jan
TI  - Long-Term Outcomes After R0 Resection of Synchronous Peritoneal Metastasis from
      Colorectal Cancer Without Cytoreductive Surgery or Hyperthermic Intraperitoneal
PG  - 173-178
LID - 10.1245/s10434-017-6133-7 [doi]
AB  - BACKGROUND: The National Comprehensive Cancer Network (NCCN) guidelines for colon
      cancer recently added the following footnote regarding the therapeutic strategy
      for peritoneal metastases: "If R0 resection can be achieved, surgical resection
      of isolated peritoneal disease may be considered at experienced centers." This
      study investigated the efficacy of R0 resection of peritoneal metastasis from
      colorectal cancer without cytoreductive surgery or hyperthermic intraperitoneal
      chemotherapy (HIPEC). METHODS: This retrospective cohort study was conducted at a
      single-institution tertiary care cancer center. Among 496 consecutive M1c
      colorectal cancer patients, R0 resection was achieved for 94 patients (19%). The 
      subjects were 78 consecutive patients with colorectal cancer and simultaneous
      peritoneal metastasis but no other distant metastases who underwent R0 resection 
      at the National Cancer Center Hospital from 1971 to 2016 (16% of all M1c
      patients). Overall survival (OS) was investigated, and clinicopathologic
      variables were analyzed for prognostic significance. RESULTS: No perioperative
      mortality was noted. The 3-year OS rate was 45%, and the 5-year OS rate was
      28.7%. The median survival time was 33.4 months. Notably, 17 patients survived
      for more than 5 years, and 9 of these patients did not receive any chemotherapy. 
      Multivariate analysis showed cancer location in the colon and harvesting of 12 or
      more lymph nodes to be independent factors associated with a better prognosis.
      CONCLUSIONS: From the perspective of long-term outcomes and no perioperative
      mortality, R0 resection of peritoneal metastasis from colorectal cancer, without 
      complete peritonectomy or HIPEC, appeared to be an acceptable therapeutic option 
      for some patients with peritoneal metastasis.
FAU - Shida, Dai
AU  - Shida D
AD  - Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
FAU - Tsukamoto, Shunsuke
AU  - Tsukamoto S
AD  - Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
FAU - Ochiai, Hiroki
AU  - Ochiai H
AD  - Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
FAU - Kanemitsu, Yukihide
AU  - Kanemitsu Y
AD  - Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20171023
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
RN  - 04ZR38536J (Oxaliplatin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Chemotherapy, Adjuvant
MH  - Colorectal Neoplasms/drug therapy/pathology/*surgery
MH  - Cytoreduction Surgical Procedures
MH  - Female
MH  - Fluorouracil/administration & dosage
MH  - Humans
MH  - Hyperthermia, Induced
MH  - *Lymph Node Excision
MH  - Male
MH  - Metastasectomy
MH  - Middle Aged
MH  - Neoplasm, Residual
MH  - Oxaliplatin/administration & dosage
MH  - Peritoneal Neoplasms/drug therapy/*pathology/secondary/*surgery
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Time Factors
MH  - Tumor Burden
OT  - Colorectal cancer
OT  - NCCN guidelines
OT  - Peritoneal metastasis
OT  - R0 resection
EDAT- 2017/10/25 06:00
MHDA- 2019/03/05 06:00
CRDT- 2017/10/25 06:00
PHST- 2017/08/05 00:00 [received]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
PHST- 2017/10/25 06:00 [entrez]
AID - 10.1245/s10434-017-6133-7 [doi]
AID - 10.1245/s10434-017-6133-7 [pii]
PST - ppublish
SO  - Ann Surg Oncol. 2018 Jan;25(1):173-178. doi: 10.1245/s10434-017-6133-7. Epub 2017
      Oct 23.