PMID- 29063192
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20181113
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 255
IP  - 12
DP  - 2017 Dec
TI  - Spectrum of retinal abnormalities in renal transplant patients using chronic
      low-dose steroids.
PG  - 2443-2449
LID - 10.1007/s00417-017-3823-6 [doi]
AB  - PURPOSE: To assess the ophthalmological characteristics of asymptomatic patients 
      with a renal transplant on chronic low-dose steroids for at least the last 2
      years prior to examination. METHODS: Cross-sectional study. All patients
      underwent an extensive ophthalmological examination. RESULTS: Of the 37 included 
      patients [25 male, 12 female; 59 +/- 11 years (range, 38-77 years)]
      ophthalmological phenotyping revealed abnormalities in 22 patients (59%).
      Findings characteristic for (subclinical) central serous chorioretinopathy were
      detected in ten patients (27%), including two patients with serous subretinal
      fluid in the macula. An epiretinal membrane of the macula was present in six
      patients (16%). Mean subfoveal choroidal thickness was significantly increased in
      patients with ophthalmological abnormalities, in comparison with patients without
      abnormalities. CONCLUSIONS: Retinal abnormalities are common in the majority of
      renal transplant patients using chronic low-dose steroids. These retinal changes 
      may be associated with the renal disease and/or the effect of chronic steroid use
      on the choroid and retina.
FAU - van Dijk, Elon H C
AU  - van Dijk EHC
AD  - Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2,
      2333 ZA, Leiden, the Netherlands.
FAU - Soonawala, Darius
AU  - Soonawala D
AD  - Department of Medicine, Division of Nephrology, and Leiden Transplant Center,
      Leiden University Medical Center, Leiden, the Netherlands.
AD  - Department of Medicine, Division of Nephrology, Haga Hospital, the Hague, the
      Netherlands.
FAU - Rooth, Vera
AU  - Rooth V
AD  - Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2,
      2333 ZA, Leiden, the Netherlands.
FAU - Hoyng, Carel B
AU  - Hoyng CB
AD  - Department of Ophthalmology, Donders Institute of Brain, Cognition, and
      Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
FAU - Meijer, Onno C
AU  - Meijer OC
AD  - Department of Medicine, Division of Endocrinology and Metabolism, Leiden
      University Medical Center, Leiden, the Netherlands.
AD  - Einthoven Laboratory for Experimental Vascular Medicine, Leiden University
      Medical Center, Leiden, the Netherlands.
FAU - de Vries, Aiko P J
AU  - de Vries APJ
AD  - Department of Medicine, Division of Nephrology, and Leiden Transplant Center,
      Leiden University Medical Center, Leiden, the Netherlands.
FAU - Boon, Camiel J F
AU  - Boon CJF
AD  - Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2,
      2333 ZA, Leiden, the Netherlands. c.j.f.boon@lumc.nl.
AD  - Department of Ophthalmology, Academic Medical Center, University of Amsterdam,
      P.O. Box 9600, 2300 RC, Leiden, The Netherlands. c.j.f.boon@lumc.nl.
LA  - eng
PT  - Journal Article
DEP - 20171023
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Administration, Sublingual
MH  - Adult
MH  - Aged
MH  - Choroid/drug effects/pathology
MH  - Cross-Sectional Studies
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Glucocorticoids/*administration & dosage
MH  - Graft Rejection/complications/*prevention & control
MH  - Humans
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Ophthalmoscopy
MH  - Retina/drug effects/*pathology
MH  - Retinal Diseases/*diagnosis/etiology
MH  - Time Factors
MH  - Tomography, Optical Coherence/*methods
PMC - PMC5696484
OTO - NOTNLM
OT  - Cross-sectional study
OT  - Ophthalmological examination
OT  - Renal transplant
OT  - Retinal phenotyping
OT  - Steroid use
EDAT- 2017/10/25 06:00
MHDA- 2018/01/05 06:00
CRDT- 2017/10/25 06:00
PHST- 2017/07/31 00:00 [received]
PHST- 2017/10/05 00:00 [accepted]
PHST- 2017/09/20 00:00 [revised]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
PHST- 2017/10/25 06:00 [entrez]
AID - 10.1007/s00417-017-3823-6 [doi]
AID - 10.1007/s00417-017-3823-6 [pii]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2017 Dec;255(12):2443-2449. doi:
      10.1007/s00417-017-3823-6. Epub 2017 Oct 23.