PMID- 29055130
OWN - NLM
STAT- MEDLINE
DCOM- 20180719
LR  - 20180719
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 140
IP  - 2
DP  - 2018 Feb
TI  - Randomized trial of combined cabergoline and coasting in preventing ovarian
      hyperstimulation syndrome during in vitro fertilization/intracytoplasmic sperm
      injection cycles.
PG  - 217-222
LID - 10.1002/ijgo.12360 [doi]
AB  - OBJECTIVE: To assess the efficacy of coasting alone, cabergoline alone, or
      combining both interventions for preventing ovarian hyperstimulation syndrome
      (OHSS) among high-risk patients undergoing in vitro
      fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment cycles.
      METHODS: The present randomized controlled trial was conducted at the IVF unit of
      a university hospital in Cairo between October 28, 2013, and July 31, 2015.
      Patients undergoing IVF/ICSI considered at risk of OHSS were randomly allocated
      to coasting, cabergoline, or combined coasting and cabergoline. The primary
      outcome was the rate and degree of symptomatically assessed OHSS. Data were
      analyzed on a per-protocol basis. RESULTS: There were 100 patients recruited to
      each group. The occurrence of early OHSS was lowest in the combination group
      compared with the other groups (P=0.002). CONCLUSION: Combining coasting and
      cabergoline was associated with a lower OHSS rate compared with either therapy
      alone. CLINICALTRIALS.GOV: NCT01984320.
CI  - (c) 2017 International Federation of Gynecology and Obstetrics.
FAU - Bassiouny, Yasmin A
AU  - Bassiouny YA
AD  - Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt.
FAU - Dakhly, Dina M R
AU  - Dakhly DMR
AD  - Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt.
FAU - Bayoumi, Yomna A
AU  - Bayoumi YA
AD  - Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt.
FAU - Salaheldin, Noha M
AU  - Salaheldin NM
AD  - Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt.
FAU - Gouda, Hisham M
AU  - Gouda HM
AD  - Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt.
FAU - Hassan, Ayman A
AU  - Hassan AA
AD  - Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt.
LA  - eng
SI  - ClinicalTrials.gov/NCT01984320
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20171109
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
RN  - 0 (Dopamine Agonists)
RN  - 0 (Ergolines)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 4TI98Z838E (Estradiol)
RN  - LL60K9J05T (cabergoline)
SB  - IM
MH  - Adult
MH  - Dopamine Agonists/*administration & dosage
MH  - Ergolines/*administration & dosage
MH  - Estradiol/blood
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*antagonists & inhibitors
MH  - Humans
MH  - Ovarian Hyperstimulation Syndrome/epidemiology/*prevention & control
MH  - Ovulation Induction/*methods
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - Sperm Injections, Intracytoplasmic/*methods
OTO - NOTNLM
OT  - OHSS
OT  - Dopamine agonist
OT  - IVF/ICSI
OT  - Long luteal agonist protocol
OT  - Withholding gonadotropins
EDAT- 2017/10/22 06:00
MHDA- 2018/07/20 06:00
CRDT- 2017/10/22 06:00
PHST- 2017/06/06 00:00 [received]
PHST- 2017/08/16 00:00 [revised]
PHST- 2017/10/20 00:00 [accepted]
PHST- 2017/10/22 06:00 [pubmed]
PHST- 2018/07/20 06:00 [medline]
PHST- 2017/10/22 06:00 [entrez]
AID - 10.1002/ijgo.12360 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2018 Feb;140(2):217-222. doi: 10.1002/ijgo.12360. Epub
      2017 Nov 9.