PMID- 29055095
OWN - NLM
STAT- MEDLINE
DCOM- 20180928
LR  - 20190329
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 142
IP  - 6
DP  - 2018 Mar 15
TI  - The joint effects of major lifestyle factors on colorectal cancer risk among
      Chinese men: A prospective cohort study.
PG  - 1093-1101
LID - 10.1002/ijc.31126 [doi]
AB  - Previous studies have suggested individual healthy lifestyle factors are related 
      to lower risk of colorectal cancer. Their joint effects, however, have rarely
      been investigated. We aimed to assess the combined lifestyle impact on colorectal
      cancer risk and to estimate the population attributable risks of these lifestyle 
      factors. Using data from the Shanghai Men's Health Study (2002-2013), we
      constructed healthy lifestyle index composing the following lifestyle factors:
      smoking, alcohol consumption, diet, waist-hip ratio and exercise participation.
      Cox proportional hazards models were used to calculate the hazard ratios (HRs)
      and 95% confidence intervals (CIs). Over a median of 9.28 years' follow-up, 671
      colorectal cancer cases occurred (400 colon cancer and 274 rectal cancer) among
      59,503 men. Each increment of healthy lifestyle index was associated with a 17%
      lower risk of colorectal cancer (HR = 0.83, 95% CI: 0.78, 0.89), 10% of colon
      cancer (HR = 0.90, 95% CI: 0.83, 0.99) and 27% of rectal cancer (HR = 0.73, 95%
      CI: 0.66, 0.82). If all men in the cohort followed a lifestyle as defined by
      these five factors, 21% colorectal cancer cases would have been prevented (PAR = 
      21%, 95% CI: 4%, 36%). In conclusion, combined lifestyle factors are
      significantly related to lower risk of colorectal cancer and the effects are more
      pronounced on rectal cancer than on colon cancer.
CI  - (c) 2017 UICC.
FAU - Zhang, Qing-Li
AU  - Zhang QL
AD  - State Key Laboratory of Oncogenes and Related Genes & Department of Epidemiology,
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of
      Medicine, Shanghai, 200032, People's Republic of China.
FAU - Zhao, Long-Gang
AU  - Zhao LG
AD  - State Key Laboratory of Oncogenes and Related Genes & Department of Epidemiology,
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of
      Medicine, Shanghai, 200032, People's Republic of China.
FAU - Li, Hong-Lan
AU  - Li HL
AD  - State Key Laboratory of Oncogenes and Related Genes & Department of Epidemiology,
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of
      Medicine, Shanghai, 200032, People's Republic of China.
FAU - Gao, Jing
AU  - Gao J
AD  - State Key Laboratory of Oncogenes and Related Genes & Department of Epidemiology,
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of
      Medicine, Shanghai, 200032, People's Republic of China.
FAU - Yang, Gong
AU  - Yang G
AD  - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center,
      Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine,
      Nashville, TN.
FAU - Wang, Jing
AU  - Wang J
AD  - State Key Laboratory of Oncogenes and Related Genes & Department of Epidemiology,
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of
      Medicine, Shanghai, 200032, People's Republic of China.
FAU - Zheng, Wei
AU  - Zheng W
AUID- ORCID: 0000-0003-1226-070X
AD  - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center,
      Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine,
      Nashville, TN.
FAU - Shu, Xiao-Ou
AU  - Shu XO
AD  - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center,
      Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine,
      Nashville, TN.
FAU - Xiang, Yong-Bing
AU  - Xiang YB
AUID- ORCID: 0000-0002-3840-9915
AD  - State Key Laboratory of Oncogenes and Related Genes & Department of Epidemiology,
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of
      Medicine, Shanghai, 200032, People's Republic of China.
LA  - eng
GR  - R01 CA082729/CA/NCI NIH HHS/United States
GR  - UM1 CA173640/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20171106
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alcohol Drinking/adverse effects
MH  - Asian Continental Ancestry Group
MH  - Colorectal Neoplasms/*etiology
MH  - Diet/adverse effects
MH  - Exercise/physiology
MH  - Humans
MH  - Life Style
MH  - Male
MH  - Men's Health
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Smoking/adverse effects
MH  - Waist-Hip Ratio/adverse effects
PMC - PMC5816935
MID - NIHMS928643
OTO - NOTNLM
OT  - *cohort study
OT  - *colorectal cancer
OT  - *lifestyle behaviors
OT  - *population attributable risk
OT  - *public health
EDAT- 2017/10/22 06:00
MHDA- 2018/10/03 06:00
CRDT- 2017/10/22 06:00
PHST- 2017/06/07 00:00 [received]
PHST- 2017/10/03 00:00 [revised]
PHST- 2017/10/12 00:00 [accepted]
PHST- 2017/10/22 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2017/10/22 06:00 [entrez]
AID - 10.1002/ijc.31126 [doi]
PST - ppublish
SO  - Int J Cancer. 2018 Mar 15;142(6):1093-1101. doi: 10.1002/ijc.31126. Epub 2017 Nov
      6.