PMID- 29024688
OWN - NLM
STAT- In-Data-Review
LR  - 20180201
IS  - 1523-1747 (Electronic)
IS  - 0022-202X (Linking)
VI  - 138
IP  - 2
DP  - 2018 Feb
TI  - Vitiligo Skin: Exploring the Dermal Compartment.
PG  - 394-404
LID - S0022-202X(17)33029-4 [pii]
LID - 10.1016/j.jid.2017.06.033 [doi]
AB  - There is an increasing interest in the apparently normal skin in vitiligo.
      Altered expression of the adhesion molecule E-cadherin and persistent deregulated
      intracellular redox status that promotes the acquisition of a stress-induced
      senescent phenotype in melanocytes of normally pigmented skin from patients with 
      vitiligo have been described. Growing evidence has shown that such cellular and
      functional alterations are not necessarily restricted to melanocytes but may be
      extended to other cutaneous cell populations in both lesional and nonlesional
      areas. However, whether dermal fibroblasts exhibit related alterations that may
      contribute to the defects associated with melanocytes in vitiligo is not known.
      Here we reveal within the dermal compartment cells a myofibroblast phenotype and 
      a predisposition to premature senescence, indicating the existence of altered
      cross-talk between dermal and epidermal components that may affect melanocyte
      functionality even in the apparently normal skin of patients with vitiligo.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Kovacs, Daniela
AU  - Kovacs D
AD  - Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San
      Gallicano Dermatologic Institute, IRCCS, Rome, Italy.
FAU - Bastonini, Emanuela
AU  - Bastonini E
AD  - Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San
      Gallicano Dermatologic Institute, IRCCS, Rome, Italy.
FAU - Ottaviani, Monica
AU  - Ottaviani M
AD  - Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San
      Gallicano Dermatologic Institute, IRCCS, Rome, Italy.
FAU - Cota, Carlo
AU  - Cota C
AD  - Dermatopathological Laboratory, San Gallicano Dermatologic Institute, IRCCS,
      Rome, Italy.
FAU - Migliano, Emilia
AU  - Migliano E
AD  - Department of Plastic and Reconstructive Surgery, San Gallicano Dermatologic
      Institute, IRCCS, Rome, Italy.
FAU - Dell'Anna, Maria Lucia
AU  - Dell'Anna ML
AD  - Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San
      Gallicano Dermatologic Institute, IRCCS, Rome, Italy.
FAU - Picardo, Mauro
AU  - Picardo M
AD  - Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San
      Gallicano Dermatologic Institute, IRCCS, Rome, Italy. Electronic address:
      mauro.picardo@ifo.gov.it.
LA  - eng
PT  - Journal Article
DEP - 20171010
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
EDAT- 2017/10/13 06:00
MHDA- 2017/10/13 06:00
CRDT- 2017/10/13 06:00
PHST- 2016/12/28 00:00 [received]
PHST- 2017/06/21 00:00 [revised]
PHST- 2017/06/27 00:00 [accepted]
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2017/10/13 06:00 [medline]
PHST- 2017/10/13 06:00 [entrez]
AID - S0022-202X(17)33029-4 [pii]
AID - 10.1016/j.jid.2017.06.033 [doi]
PST - ppublish
SO  - J Invest Dermatol. 2018 Feb;138(2):394-404. doi: 10.1016/j.jid.2017.06.033. Epub 
      2017 Oct 10.