PMID- 28991702
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20180611
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 381
DP  - 2017 Oct 15
TI  - Cerebral autoregulation is preserved in multiple sclerosis patients.
PG  - 298-304
LID - S0022-510X(17)34290-9 [pii]
LID - 10.1016/j.jns.2017.09.009 [doi]
AB  - Multiple sclerosis (MS) is an inflammatory disease that may also be associated
      with vascular dysfunction. One master component of vascular regulation is
      cerebral autoregulation (CA). We aimed to investigate the integrity of CA in MS
      patients and study its relationship with autonomic dysfunction (AD),
      magnetic-resonance-imaging (MRI) lesion load and hemodynamic parameters. We
      enrolled 20 relapsing-remitting MS and 20 healthy subjects. CA was assessed by
      transfer function analysis parameters (coherence, gain and phase), as obtained in
      the very low, low and high-frequency domains (VLF, LF, HF, respectively). We
      evaluated the autonomic parameters heart rate variability and spontaneous
      baroreflex sensitivity (BRS). There were no significant differences in CA
      parameters between MS and controls (p>0.05). Lesion load was not correlated with 
      any CA parameter. LF gain was positively correlated with BRS in both groups (MS: 
      p=0.017; controls: p=0.025). Brainstem lesion load in MS was associated with
      higher systolic blood pressure (SBP; p=0.009). Our findings suggest that CA is
      preserved in our MS cohort. On the other hand, AD in MS patients with brainstem
      lesions could contribute to the increase of supine SBP. Whether this systemic
      deregulation could contribute to disease burden remains to be investigated.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Ferreira, Daniel
AU  - Ferreira D
AD  - Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of
      University of Porto, 4200-319 Porto, Portugal. Electronic address:
      mimed11108@med.up.pt.
FAU - Castro, Pedro
AU  - Castro P
AD  - Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of
      University of Porto, 4200-319 Porto, Portugal; Department of Neurology, Sao Joao 
      Hospital Center, 4200-319 Porto, Portugal.
FAU - Videira, Goncalo
AU  - Videira G
AD  - Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of
      University of Porto, 4200-319 Porto, Portugal.
FAU - Filipe, Joao Pedro
AU  - Filipe JP
AD  - Department of Neuroradiology, Hospital Center Sao Joao, 4200-319 Porto, Portugal.
FAU - Santos, Rosa
AU  - Santos R
AD  - Department of Neurology, Sao Joao Hospital Center, 4200-319 Porto, Portugal.
FAU - Sa, Maria Jose
AU  - Sa MJ
AD  - Department of Neurology, Sao Joao Hospital Center, 4200-319 Porto, Portugal;
      Faculty of Health Sciences, University Fernando Pessoa, 4249-004 Porto, Portugal.
FAU - Azevedo, Elsa
AU  - Azevedo E
AD  - Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of
      University of Porto, 4200-319 Porto, Portugal; Department of Neurology, Sao Joao 
      Hospital Center, 4200-319 Porto, Portugal.
FAU - Abreu, Pedro
AU  - Abreu P
AD  - Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of
      University of Porto, 4200-319 Porto, Portugal; Department of Neurology, Sao Joao 
      Hospital Center, 4200-319 Porto, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20170908
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Adult
MH  - Autonomic Nervous System/*physiopathology
MH  - Baroreflex/physiology
MH  - Brain/*physiology
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Heart Rate/physiology
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnostic imaging/*physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Autonomic nervous system
OT  - Cerebral autoregulation
OT  - Heart rate variability
OT  - Magnetic resonance imaging
OT  - Multiple sclerosis
OT  - Spontaneous baroreflex sensitivity
EDAT- 2017/10/11 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/10/10 06:00
PHST- 2017/07/02 00:00 [received]
PHST- 2017/08/23 00:00 [revised]
PHST- 2017/09/06 00:00 [accepted]
PHST- 2017/10/10 06:00 [entrez]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
AID - S0022-510X(17)34290-9 [pii]
AID - 10.1016/j.jns.2017.09.009 [doi]
PST - ppublish
SO  - J Neurol Sci. 2017 Oct 15;381:298-304. doi: 10.1016/j.jns.2017.09.009. Epub 2017 
      Sep 8.