PMID- 28980009
OWN - NLM
STAT- MEDLINE
DCOM- 20180424
LR  - 20181202
IS  - 1651-2081 (Electronic)
IS  - 1650-1977 (Linking)
VI  - 50
IP  - 1
DP  - 2018 Jan 10
TI  - Adaptations of fatigue and fatigability after a short intensive, combined
      rehabilitation program in patients with multiple sclerosis.
PG  - 59-66
LID - 10.2340/16501977-2277 [doi]
AB  - OBJECTIVE: Fatigue and fatigability are common problems in patients with multiple
      sclerosis, which might be improved by rehabilitation. The aim of this pilot study
      was to assess changes in the fatigue and fatigability of knee extensors in
      patients with multiple sclerosis after a short intensive, combined rehabilitation
      programme (including physiotherapy primarily focused on gait and balance,
      endurance and resistance training). METHODS: Twenty-three patients with multiple 
      sclerosis (10 men, 13 women) underwent isokinetic evaluations of fatigability of 
      the knee extensor muscles during concentric contractions and rated a
      self-reported fatigue scale (Modified Fatigue Impact Scale; MFIS) before and
      after a rehabilitation programme. Patients performed rehabilitation for 150 min, 
      4 days per week for 4 weeks, with physiotherapy focused primarily on gait and
      balance, endurance training and resistance training. RESULTS: After
      rehabilitation, perception of fatigue decreased significantly (median MFIS scores
      [1st; 3rd quartiles], pre: 44 [33; 53] vs post: 33.5 [16; 43]; <0.00025). Moment 
      fatigue index increased (pre: 37.70+/-13.40 vs post: 48.10+/-9.39; p<0.0125), but
      end-test moment did not change. After rehabilitation, strength increased during
      both isometric and concentric contraction (mean first 5 and mean 50 contractions 
      of the fatigue protocol) (p<0.0125). After rehabilitation, neuromuscular
      efficiency improved (p<0.0125). CONCLUSION: After a short, intensive, combined
      rehabilitation programme, fatigue decreased but fatigability increased (moment
      fatigue index). Indeed, fatigability increased because strength in the initial
      state increased and strength in the fatigued state did not change. Although the
      rehabilitation programme was designed so that resistance training was carried out
      after endurance training to specifically train muscles in a fatigued state, no
      improvements in strength in the fatigued state were measured.
FAU - Hameau, Sophie
AU  - Hameau S
AD  - Inserm Unit 1179, Team 3: Technology and Innovative Therapies Applied to
      Neuromuscular Diseases, University of Versailles Saint Quentin en Yvelines, 92380
      Garches, France. sophie.hameau@aphp.fr.
FAU - Bensmail, Djamel
AU  - Bensmail D
FAU - Roche, Nicolas
AU  - Roche N
FAU - Zory, Raphael
AU  - Zory R
LA  - eng
PT  - Journal Article
PL  - Sweden
TA  - J Rehabil Med
JT  - Journal of rehabilitation medicine
JID - 101088169
SB  - IM
MH  - Fatigue/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*rehabilitation
MH  - Muscle Fatigue/*physiology
MH  - Pilot Projects
MH  - Resistance Training/*methods
EDAT- 2017/10/06 06:00
MHDA- 2018/04/25 06:00
CRDT- 2017/10/06 06:00
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2018/04/25 06:00 [medline]
PHST- 2017/10/06 06:00 [entrez]
AID - 10.2340/16501977-2277 [doi]
PST - ppublish
SO  - J Rehabil Med. 2018 Jan 10;50(1):59-66. doi: 10.2340/16501977-2277.