PMID- 28973337
OWN - NLM
STAT- MEDLINE
DCOM- 20171006
LR  - 20180307
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 11
DP  - 2017 Sep 1
TI  - Myopia and Exposure to Organophosphate and Pyrethroid Pesticides in the General
      United States Population.
PG  - 4915-4924
LID - 10.1167/iovs.16-20493 [doi]
AB  - Purpose: Previous research suggests that exposure to pesticides might be
      associated with human myopia, although data were obtained only from highly
      exposed individuals. The present study aimed to assess whether exposure to
      organophosphates and pyrethroids in the United States general population was
      associated with the prevalence of myopia. Methods: Data were obtained from the
      National Health and Nutrition Examination Survey (NHANES, years 1999-2008).
      One-spot urine samples were used to estimate the concentration of several
      pesticide metabolites. Exposure data and equivalent spherical refraction errors
      were available for 5147 and 2911 individuals for organophosphates and
      pyrethroids, respectively. Multiple logistic regression models were used to
      assess the relation between log10-transformed urinary levels of pesticide
      metabolites and the risk of moderate (</=-1 and >-5 diopters [D]) and high myopia
      (</=-5 D) in adolescents (12- to 19-years old) and young adults (20- to 40-years 
      old). Models were adjusted for sex, age, ethnicity, diabetes, creatinine, cadmium
      and lead concentrations, and income in both age groups, but also for education
      level and cigarette and alcohol consumption in the adult group. Results: No
      association between organophosphates or pyrethroid metabolites and myopia was
      observed. However, after adjusting for education level and cigarette and alcohol 
      consumption, a statistically significant decreased risk of high myopia in those
      with a 10-fold increase of dialkyl phosphate metabolites was found in adults but 
      only in men (P < 0.05). Conclusions: Our results suggest that exposure to
      organophosphates or pyrethroids do not increase the risk of myopia in the United 
      States general population.
FAU - Migneron-Foisy, Vincent
AU  - Migneron-Foisy V
AD  - Department of Psychology, Universite du Quebec a Montreal, Montreal, Quebec,
      Canada.
AD  - Sainte-Justine University Hospital Research Center, Montreal, Quebec, Canada.
FAU - Bouchard, Maryse F
AU  - Bouchard MF
AD  - Sainte-Justine University Hospital Research Center, Montreal, Quebec, Canada.
AD  - Department of Environmental and Occupational Health, Universite de Montreal,
      Montreal, Quebec, Canada.
FAU - Freeman, Ellen E
AU  - Freeman EE
AD  - School of Epidemiology, Public Health, and Preventive Medicine, University of
      Ottawa, Ottawa, Ontario, Canada.
FAU - Saint-Amour, Dave
AU  - Saint-Amour D
AD  - Department of Psychology, Universite du Quebec a Montreal, Montreal, Quebec,
      Canada.
AD  - Sainte-Justine University Hospital Research Center, Montreal, Quebec, Canada.
AD  - Department of Ophtalmology, Universite de Montreal, Montreal, Quebec, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organophosphates)
RN  - 0 (Pesticides)
RN  - 0 (Pyrethrins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Environmental Exposure/*adverse effects/statistics & numerical data
MH  - Environmental Pollutants/toxicity/*urine
MH  - Female
MH  - Humans
MH  - Male
MH  - Myopia/chemically induced/*epidemiology
MH  - Organophosphates/toxicity/*urine
MH  - Pesticides/toxicity/*urine
MH  - Prevalence
MH  - Pyrethrins/toxicity/*urine
MH  - United States/epidemiology
MH  - Young Adult
EDAT- 2017/10/04 06:00
MHDA- 2017/10/07 06:00
CRDT- 2017/10/04 06:00
PHST- 2017/10/04 06:00 [entrez]
PHST- 2017/10/04 06:00 [pubmed]
PHST- 2017/10/07 06:00 [medline]
AID - 2656405 [pii]
AID - 10.1167/iovs.16-20493 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4915-4924. doi:
      10.1167/iovs.16-20493.