PMID- 28966488
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20171004
IS  - 0974-2727 (Print)
IS  - 0974-2727 (Linking)
VI  - 9
IP  - 4
DP  - 2017 Oct-Dec
TI  - Changing prevalence and antibiotic drug resistance pattern of pathogens seen in
      community-acquired pediatric urinary tract infections at a tertiary care hospital
      of North India.
PG  - 264-268
LID - 10.4103/JLP.JLP_149_16 [doi]
AB  - AIMS AND OBJECTIVES: The aim and objective of this study was to assess the
      temporal changes in the microbiological profiles and antimicrobial resistance
      patterns of uropathogens in pediatric community-acquired UTI. MATERIALS AND
      METHODS: This is a retrospective analysis of data collected over a Scattered
      period of 5 years. The baseline data collected were from January to December
      2009, and the second period considered for comparison was from January to
      December 2014. Urine specimens from children (<17 years) suspected of UTI were
      cultured by a semi-quantitative method on cysteine lactose electrolyte-deficient 
      medium. Antibiotic sensitivity was put up by Kirby-Bauer disc diffusion method as
      per the Clinical and Laboratory Standard Institute guidelines. RESULTS: In the
      year 2009, 340 of 2104 (16.15%) urine specimens yielded significant colony count,
      whereas in 2014, it was 407 of 2212 (18.39%) (P = 0.051). Escherichia coli was
      the predominant pathogen and was significantly more prevalent in girls than in
      boys (P < 0.0001) during both periods. There was a significant overall increase
      in resistance to ampicillin (from 40.29% to 58.72%), amoxyclav (from 26.17% to
      40.54%), nitrofurantoin (from 28.82% to 39.06%), and norfloxacin (from 30% to
      41.42%). However, the maximum increase in the resistance was noted for
      co-trimoxazole from 35.58% in 2009 to 63.39% in 2014 (P = 0.0000058). The
      prevalence of extended-spectrum beta-lactamases (ESBLs) has also significantly
      increased from 21.7% to 33.16% (P = 0.0045). CONCLUSION: Although E. coli remains
      the prime pathogen in pediatric UTI, the prevalence of resistance has
      dramatically increased over the 5-year study period. Our study highlights the
      emergence of community-acquired ESBL-producing uropathogens in children
      proclaiming treatment challenges.
FAU - Patwardhan, Vrushali
AU  - Patwardhan V
AD  - Division of Clinical Microbiology and Molecular Medicine, Department of
      Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.
FAU - Kumar, Dinesh
AU  - Kumar D
AD  - Division of Clinical Microbiology and Molecular Medicine, Department of
      Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.
FAU - Goel, Varun
AU  - Goel V
AD  - Division of Clinical Microbiology and Molecular Medicine, Department of
      Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.
FAU - Singh, Sarman
AU  - Singh S
AD  - Division of Clinical Microbiology and Molecular Medicine, Department of
      Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Lab Physicians
JT  - Journal of laboratory physicians
JID - 101551511
PMC - PMC5607755
OTO - NOTNLM
OT  - Antimicrobials
OT  - children
OT  - extended-spectrum beta-lactamase producers
OT  - microbiological profile
OT  - resistance pattern
OT  - urinary tract infection
COIS- There are no conflicts of interest.
EDAT- 2017/10/03 06:00
MHDA- 2017/10/03 06:01
CRDT- 2017/10/03 06:00
PHST- 2017/10/03 06:00 [entrez]
PHST- 2017/10/03 06:00 [pubmed]
PHST- 2017/10/03 06:01 [medline]
AID - 10.4103/JLP.JLP_149_16 [doi]
AID - JLP-9-264 [pii]
PST - ppublish
SO  - J Lab Physicians. 2017 Oct-Dec;9(4):264-268. doi: 10.4103/JLP.JLP_149_16.