PMID- 28957343
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20171018
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 9
DP  - 2017
TI  - A prospective, observational study of patients with uncommon distal symmetric
      painful small-fiber neuropathy.
PG  - e0183948
LID - 10.1371/journal.pone.0183948 [doi]
AB  - OBJECTIVE: To investigate the clinical characteristics of patients with uncommon 
      distal symmetric painful small-fiber neuropathy (DSPSFN). METHODS: From September
      2012 to September 2014, participants between 18-70 years of age that had DSPSFN
      defined by clinical signs/symptoms and ID pain > 2 or DN4 > 4 on questionnaires
      for more than 1 month were included. Participants who had previous historical or 
      laboratory evidence of common etiologies of DSPSFN were excluded. Enzyme activity
      and genetic studies for Fabry diseaseand familial amyloid polyneuropathy were
      performed after participants fulfilled the inclusion and exclusion criteria. The 
      cryoglobulin test, autoantibodies studies and electrophysiological studies were
      performed in these participants. RESULTS: In total, 100 cases were enrolled in
      the current study. Three cases of subclinical diabetes mellitus and two cases of 
      fibromyalgia were found. Fabry disease (1%) and familial amyloid polyneuropathy
      (3%) with Ala97Ser transthyretin (TTR) mutations were also detected. The
      cryoglobulin test was positive in 30% of participants, and these participants had
      higher DN4 scores than the negative group. In the autoantibodies studies, 59% of 
      the participants had abnormal anti-Ro/SSA and/or anti-La/SSB antibodies.
      CONCLUSIONS: Cryoglobulinemia is not a rare etiology of uncommon DSPSFN. The
      long-term prognosis is quite good in these participants. From our structuralized 
      protocol, Fabry disease and familial amyloid polyneuropathy could be easily
      detected in these cases of uncommon DSPSFN.
FAU - Hsu, Jung-Lung
AU  - Hsu JL
AUID- ORCID: http://orcid.org/0000-0001-6422-8870
AD  - Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and 
      Chang Gung University College of Medicine, Taipei, Taiwan.
AD  - Taipei Medical University, Graduate Institute of Humanities in Medicine, Taipei, 
      Taiwan.
AD  - Taipei Medical University Research Center for Brain and Consciousness, Shuang Ho 
      Hospital, New Taipei City, Taiwan.
FAU - Liao, Ming-Feng
AU  - Liao MF
AD  - Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and 
      Chang Gung University College of Medicine, Taipei, Taiwan.
FAU - Hsu, Hui-Ching
AU  - Hsu HC
AD  - Department of Traditional Chinese Medicine, Division of Chinese Acupuncture and
      Traumatology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung 
      University College of Medicine, Taipei, Taiwan.
FAU - Weng, Yi-Ching
AU  - Weng YC
AD  - Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and 
      Chang Gung University College of Medicine, Taipei, Taiwan.
FAU - Lo, Ai-Lun
AU  - Lo AL
AD  - Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and 
      Chang Gung University College of Medicine, Taipei, Taiwan.
FAU - Chang, Kuo-Hsuan
AU  - Chang KH
AD  - Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and 
      Chang Gung University College of Medicine, Taipei, Taiwan.
FAU - Chang, Hong-Shiu
AU  - Chang HS
AD  - Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and 
      Chang Gung University College of Medicine, Taipei, Taiwan.
FAU - Kuo, Hung-Chou
AU  - Kuo HC
AD  - Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and 
      Chang Gung University College of Medicine, Taipei, Taiwan.
FAU - Huang, Chin-Chang
AU  - Huang CC
AD  - Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and 
      Chang Gung University College of Medicine, Taipei, Taiwan.
FAU - Ro, Long-Sun
AU  - Ro LS
AD  - Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and 
      Chang Gung University College of Medicine, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170928
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Autoantibodies/immunology
MH  - Cryoglobulinemia/complications
MH  - Demography
MH  - Electrophysiological Phenomena
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Small Fiber Neuropathy/complications/*diagnosis/immunology/physiopathology
PMC - PMC5619719
EDAT- 2017/09/29 06:00
MHDA- 2017/10/17 06:00
CRDT- 2017/09/29 06:00
PHST- 2017/05/09 00:00 [received]
PHST- 2017/08/15 00:00 [accepted]
PHST- 2017/09/29 06:00 [entrez]
PHST- 2017/09/29 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
AID - 10.1371/journal.pone.0183948 [doi]
AID - PONE-D-17-17827 [pii]
PST - epublish
SO  - PLoS One. 2017 Sep 28;12(9):e0183948. doi: 10.1371/journal.pone.0183948.
      eCollection 2017.