PMID- 28948495
OWN - NLM
STAT- MEDLINE
DCOM- 20171106
LR  - 20181113
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 62
IP  - 11
DP  - 2017 Nov
TI  - Risk Assessment of Hepatocellular Carcinoma in Patients with Hepatitis C in China
      and the USA.
PG  - 3243-3253
LID - 10.1007/s10620-017-4776-7 [doi]
AB  - BACKGROUND: Hepatitis C (HCV) infection is an increasingly common cause of
      hepatocellular carcinoma (HCC) in China. AIMS: We aimed to determine differences 
      in demographic and behavioral profiles associated with HCC in HCV+ patients in
      China and the USA. METHODS: Consecutive HCV+ patients were recruited from centers
      in China and the USA. Clinical data and lifestyle profiles were obtained through 
      standardized questionnaires. Multivariable analysis was conducted to determine
      factors associated with HCC diagnosis within groups. RESULTS: We included 41 HCC 
      patients from China and 71 from the USA, and 931 non-HCC patients in China and
      859 in China. Chinese patients with HCC were significantly younger, less likely
      to be male and to be obese than US patients with HCC (all p < 0.001). Chinese
      patients with HCC had a significantly lower rate of cirrhosis diagnosis (36.6 vs.
      78.9%, p < 0.001); however, they also had a higher rate of hepatitis B core
      antibody positivity (63.4 vs. 36.8%, p = 0.007). In a multivariable analysis of
      the entire Chinese cohort, age > 55, male sex, the presence of diabetes, and time
      from maximum weight were associated with HCC, while tea consumption was
      associated with a decreased HCC risk (OR 0.37, 95% CI 0.16-0.88). In the US
      cohort, age > 55, male sex, and cirrhosis were associated with HCC on
      multivariable analysis. CONCLUSIONS: With the aging Chinese population and
      increasing rates of diabetes, there will likely be continued increase in the
      incidence of HCV-related HCC in China. The protective effect of tea consumption
      on HCC development deserves further validation.
FAU - Parikh, Neehar D
AU  - Parikh ND
AUID- ORCID: 0000-0002-5874-9933
AD  - Division of Gastroenterology and Hepatology, University of Michigan Health
      System, 1500 E Medical Center Dr, Taubman Center SPC 3912, Ann Arbor, MI, USA.
      ndparikh@med.umich.edu.
FAU - Fu, Sherry
AU  - Fu S
AD  - Division of Gastroenterology and Hepatology, University of Michigan Health
      System, 1500 E Medical Center Dr, Taubman Center SPC 3912, Ann Arbor, MI, USA.
FAU - Rao, Huiying
AU  - Rao H
AD  - Peking University Hepatology Institute, Peking University People's Hospital,
      Peking University Health Science Center, Beijing, China.
FAU - Yang, Ming
AU  - Yang M
AD  - Peking University Hepatology Institute, Peking University People's Hospital,
      Peking University Health Science Center, Beijing, China.
FAU - Li, Yumeng
AU  - Li Y
AD  - Consulting for Statistics, Computing and Analytics Research, University of
      Michigan, Ann Arbor, MI, USA.
FAU - Powell, Corey
AU  - Powell C
AD  - Consulting for Statistics, Computing and Analytics Research, University of
      Michigan, Ann Arbor, MI, USA.
FAU - Wu, Elizabeth
AU  - Wu E
AD  - Division of Gastroenterology and Hepatology, University of Michigan Health
      System, 1500 E Medical Center Dr, Taubman Center SPC 3912, Ann Arbor, MI, USA.
FAU - Lin, Andy
AU  - Lin A
AD  - The Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann 
      Arbor, MI, USA.
FAU - Xing, Baocai
AU  - Xing B
AD  - Peking University Cancer Hospital, Peking University Health Science Center,
      Beijing, China.
FAU - Wei, Lai
AU  - Wei L
AD  - Peking University Hepatology Institute, Peking University People's Hospital,
      Peking University Health Science Center, Beijing, China.
FAU - Lok, Anna S F
AU  - Lok ASF
AD  - Division of Gastroenterology and Hepatology, University of Michigan Health
      System, 1500 E Medical Center Dr, Taubman Center SPC 3912, Ann Arbor, MI, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170925
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
SB  - AIM
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Carcinoma, Hepatocellular/diagnosis/*epidemiology/prevention & control/virology
MH  - Chi-Square Distribution
MH  - China/epidemiology
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hepatitis C, Chronic/diagnosis/*epidemiology/virology
MH  - Humans
MH  - Life Style
MH  - Liver Neoplasms/diagnosis/*epidemiology/prevention & control/virology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Prognosis
MH  - Protective Factors
MH  - Risk Assessment
MH  - Risk Factors
MH  - Risk Reduction Behavior
MH  - Sex Factors
MH  - Surveys and Questionnaires
MH  - United States/epidemiology
OTO - NOTNLM
OT  - *Diabetes
OT  - *HCC
OT  - *HCV
OT  - *Lifestyle
OT  - *Tea
EDAT- 2017/09/28 06:00
MHDA- 2017/11/07 06:00
CRDT- 2017/09/27 06:00
PHST- 2017/07/12 00:00 [received]
PHST- 2017/09/19 00:00 [accepted]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2017/11/07 06:00 [medline]
PHST- 2017/09/27 06:00 [entrez]
AID - 10.1007/s10620-017-4776-7 [doi]
AID - 10.1007/s10620-017-4776-7 [pii]
PST - ppublish
SO  - Dig Dis Sci. 2017 Nov;62(11):3243-3253. doi: 10.1007/s10620-017-4776-7. Epub 2017
      Sep 25.