PMID- 28939690
OWN - NLM
STAT- In-Data-Review
LR  - 20180625
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 102
IP  - 7
DP  - 2018 Jul
TI  - Comparison of anterior segment optical coherence tomography angiography systems
      for corneal vascularisation.
PG  - 873-877
LID - 10.1136/bjophthalmol-2017-311072 [doi]
AB  - AIM: To newly describe a spectral-domain (SD) optical coherence tomography
      angiography (OCTA) for the cornea and directly compare two OCTA system scans of
      the same eyes with corneal vascularisation. METHODS: Cross-sectional,
      observational, comparative case series. We performed sequential OCTA scans (10
      eyes of 10 subjects with corneal vascularisation,4 scans each eye) repeated using
      split-spectrum amplitude decorrelation algorithm angiography system (SSADA,
      AngioVue; Optovue Inc, USA) and SD OCTA (Angioscan; Nidek Co. Ltd, Japan) in the 
      same region of interest. We analysed all scan images for repeatability, image
      quality and vessel density measurements and compared OCTA systems. RESULTS: We
      obtained substantial interobserver repeatability in terms of image quality score 
      (kappa=0.86) for all 80 OCTA scans (median age 49 years, 50% women). The
      correlation was moderately good (r=0.721) when comparing vessel density
      measurements between OCTA systems, but greater in the SSADA compared with SD OCTA
      system (mean vessel density 20.3+/-4.9% vs 15.1+/-4.2%, respectively; p<0.001).
      CONCLUSION: In this pilot clinical study, we describe successful delineation of
      corneal vessels with substantial image quality using a new SD OCTA system. The
      vessel density measurements were greater using the SSADA compared with SD OCTA
      system in the same area of corneal vascularisation. Further studies are required 
      to confirm the advantages, limitations and differences between these OCTA systems
      for the anterior segment.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text
      of the article) 2018. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Ang, Marcus
AU  - Ang M
AD  - Singapore National Eye Centre, Singapore.
AD  - Singapore Eye Research Institute, Singapore.
AD  - Ophthalmology and Visual Sciences, Duke-National University of Singapore,
      Singapore.
FAU - Devarajan, Kavya
AU  - Devarajan K
AD  - Singapore Eye Research Institute, Singapore.
FAU - Das, Suchandrima
AU  - Das S
AD  - Singapore Eye Research Institute, Singapore.
FAU - Stanzel, Tisha
AU  - Stanzel T
AD  - Singapore Eye Research Institute, Singapore.
FAU - Tan, Anna
AU  - Tan A
AD  - Singapore National Eye Centre, Singapore.
AD  - Singapore Eye Research Institute, Singapore.
FAU - Girard, Michael
AU  - Girard M
AD  - Singapore Eye Research Institute, Singapore.
AD  - Department of Ophthalmology, National University of Singapore, Singapore.
FAU - Schmetterer, Leopold
AU  - Schmetterer L
AD  - Singapore Eye Research Institute, Singapore.
AD  - Ophthalmology and Visual Sciences, Duke-National University of Singapore,
      Singapore.
AD  - Nanyang Technological University, Singapore.
AD  - Department of Clinical Pharmacology, Medical University of Vienna, Austria.
AD  - Center for Medical Physics and Biomedical Engineering, Medical University of
      Vienna, Austria.
FAU - Mehta, Jodhbir S
AU  - Mehta JS
AD  - Singapore National Eye Centre, Singapore.
AD  - Singapore Eye Research Institute, Singapore.
AD  - Ophthalmology and Visual Sciences, Duke-National University of Singapore,
      Singapore.
AD  - Nanyang Technological University, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20170922
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
OTO - NOTNLM
OT  - Diagnostic tests/investigation
OT  - cornea
OT  - imaging
COIS- Competing interests: None declared.
EDAT- 2017/09/25 06:00
MHDA- 2017/09/25 06:00
CRDT- 2017/09/24 06:00
PHST- 2017/07/19 00:00 [received]
PHST- 2017/08/22 00:00 [revised]
PHST- 2017/09/08 00:00 [accepted]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2017/09/25 06:00 [medline]
PHST- 2017/09/24 06:00 [entrez]
AID - bjophthalmol-2017-311072 [pii]
AID - 10.1136/bjophthalmol-2017-311072 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2018 Jul;102(7):873-877. doi: 10.1136/bjophthalmol-2017-311072. 
      Epub 2017 Sep 22.