PMID- 28939588
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20181024
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 26
IP  - 12
DP  - 2017 Dec
TI  - Childhood Socioeconomic Position and Pubertal Onset in a Cohort of Multiethnic
      Girls: Implications for Breast Cancer.
PG  - 1714-1721
LID - 10.1158/1055-9965.EPI-17-0496 [doi]
AB  - Background: Higher socioeconomic position (SEP) has been associated with
      increased risk of breast cancer. Its relationship with earlier age of pubertal
      onset, a risk factor for breast cancer, is less clear.Methods: We studied the
      relationship of SEP to pubertal onset in a multiethnic cohort of 1,237 girls ages
      6 to 8 years at baseline. Girls in three U.S. cities were followed for 5 to 8
      years with annual clinical examinations from 2004 to 2012. SEP measures were
      examined for associations with pubertal onset, assessed by breast budding
      (thelarche) and pubic hair development (adrenarche). Analyses were conducted with
      accelerated failure time models using a Weibull distribution, with left, right,
      and interval censoring.Results: Higher body mass index percentage at entry to the
      study and black or Hispanic race/ethnicity were the strongest predictors of age
      at pubertal onset. An SEP index comprising household family income, mother's
      education, and home ownership was an independent predictor of thelarche in
      adjusted models for all girls together and for white and Latina, separately, but 
      not black girls, and the relationship varied by study site. The SEP index was not
      related to adrenarche in adjusted models. Overall, girls from the lowest quintile
      of SEP entered puberty on average 6% earlier than girls from the highest quintile
      (time ratio = 0.94; 95% confidence interval 0.91-0.97) in adjusted
      models.Conclusions: Our results suggest that early-life SEP may influence the
      timing of pubertal development.Impact: Factors related to lower SEP in childhood 
      can adversely affect early development in ways that may increase the risk of
      breast cancer. Cancer Epidemiol Biomarkers Prev; 26(12); 1714-21. (c)2017 AACR.
CI  - (c)2017 American Association for Cancer Research.
FAU - Hiatt, Robert A
AU  - Hiatt RA
AD  - Department of Epidemiology & Biostatistics, University of California, San
      Francisco, San Francisco, California. robert.hiatt@ucsf.edu.
AD  - Helen Diller Family Comprehensive Cancer Center, University of California, San
      Francisco, San Francisco, California.
FAU - Stewart, Susan L
AU  - Stewart SL
AD  - Department of Public Health Sciences, University of California, Davis, Davis,
      California.
FAU - Hoeft, Kristin S
AU  - Hoeft KS
AD  - Department of Epidemiology & Biostatistics, University of California, San
      Francisco, San Francisco, California.
FAU - Kushi, Lawrence H
AU  - Kushi LH
AD  - Division of Research, Kaiser Permanente, Oakland, California.
FAU - Windham, Gayle C
AU  - Windham GC
AD  - Division of Environmental and Occupational Disease Control, California Department
      of Public Health, Richmond, California.
FAU - Biro, Frank M
AU  - Biro FM
AD  - Department of Adolescent Medicine, Cincinnati Children's Hospital Medical Center,
      Cincinnati, Ohio.
FAU - Pinney, Susan M
AU  - Pinney SM
AD  - Department of Environmental Health, University of Cincinnati College of Medicine,
      Cincinnati, Ohio.
FAU - Wolff, Mary S
AU  - Wolff MS
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, New York.
FAU - Teitelbaum, Susan L
AU  - Teitelbaum SL
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, New York.
FAU - Braithwaite, Dejana
AU  - Braithwaite D
AD  - Department of Epidemiology & Biostatistics, University of California, San
      Francisco, San Francisco, California.
LA  - eng
GR  - P30 CA093373/CA/NCI NIH HHS/United States
GR  - U01 ES012770/ES/NIEHS NIH HHS/United States
GR  - U01 ES012800/ES/NIEHS NIH HHS/United States
GR  - P01 ES009584/ES/NIEHS NIH HHS/United States
GR  - F31 DE023282/DE/NIDCR NIH HHS/United States
GR  - R03 CA143936/CA/NCI NIH HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - U01 ES012771/ES/NIEHS NIH HHS/United States
GR  - P30 ES006096/ES/NIEHS NIH HHS/United States
GR  - U01 ES012801/ES/NIEHS NIH HHS/United States
GR  - U01 ES019453/ES/NIEHS NIH HHS/United States
GR  - U01 ES019457/ES/NIEHS NIH HHS/United States
GR  - U01 ES019454/ES/NIEHS NIH HHS/United States
GR  - UL1 RR029887/RR/NCRR NIH HHS/United States
GR  - U01 ES019435/ES/NIEHS NIH HHS/United States
GR  - UL1 RR026314/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170922
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American
      Association for Cancer Research, cosponsored by the American Society of
      Preventive Oncology
JID - 9200608
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Body Mass Index
MH  - Breast/growth & development
MH  - Breast Neoplasms/*epidemiology/physiopathology
MH  - Female
MH  - Humans
MH  - Prospective Studies
MH  - Puberty/*physiology
MH  - Risk Factors
MH  - Sexual Maturation/*physiology
MH  - *Social Class
MH  - Young Adult
PMC - PMC5712280
MID - NIHMS908506
EDAT- 2017/09/25 06:00
MHDA- 2018/07/18 06:00
CRDT- 2017/09/24 06:00
PMCR- 2018/12/01 00:00
PHST- 2017/06/07 00:00 [received]
PHST- 2017/08/03 00:00 [revised]
PHST- 2017/09/18 00:00 [accepted]
PHST- 2018/12/01 00:00 [pmc-release]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2017/09/24 06:00 [entrez]
AID - 1055-9965.EPI-17-0496 [pii]
AID - 10.1158/1055-9965.EPI-17-0496 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2017 Dec;26(12):1714-1721. doi:
      10.1158/1055-9965.EPI-17-0496. Epub 2017 Sep 22.