PMID- 28935401
OWN - NLM
STAT- In-Data-Review
LR  - 20180323
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 125
IP  - 4
DP  - 2018 Apr
TI  - Long-Term Endothelial Cell Loss in Patients with Artisan Myopia and Artisan Toric
      Phakic Intraocular Lenses: 5- and 10-Year Results.
PG  - 486-494
LID - S0161-6420(17)31290-3 [pii]
LID - 10.1016/j.ophtha.2017.08.011 [doi]
AB  - PURPOSE: To evaluate the long-term change in endothelial cell density (ECD) after
      the implantation of 2 types of rigid iris-fixated phakic intraocular lenses
      (pIOLs) for the treatment of myopia and astigmatism. DESIGN: Prospective,
      clinical cohort study. PARTICIPANTS: A total of 507 eyes of 289 patients
      receiving the Artisan Myopia or Artisan Toric (Ophtec B.V., Groningen, The
      Netherlands) iris-fixated pIOL for the treatment of myopia or astigmatism at the 
      University Eye Clinic Maastricht as of January 1998. METHODS: A total of 381
      myopic and 126 toric pIOLs were implanted. Five- and 10-year follow-ups were
      completed by 193 and 127 eyes implanted with the myopic pIOL and by 40 and 20
      eyes implanted with the toric pIOL, respectively. MAIN OUTCOME MEASURES: Chronic 
      endothelial cell (EC) loss, percentage of eyes with a decrease of >/=25% in ECD, 
      and percentage of eyes with an ECD <1500 cells/mm(2). RESULTS: Chronic EC loss
      was calculated from 6 months postoperatively to the end of follow-up and showed
      an annual ECD decline of 48 cells/mm(2) (standard error, 3.14) and 61 cells/mm(2)
      (standard error, 6.30) in the myopic (P < 0.001) and toric (P < 0.001) groups,
      respectively, resulting in a total EC loss of 16.6% and 21.5% from 6 months to 10
      years postoperatively, respectively. Ten years after implantation, ECD had
      decreased by >/=25% in 7.9% and 6.3%, whereas ECD was <1500 cells/mm(2) in 3.9%
      and 4.0% in the myopic and toric groups, respectively. Explantation of the pIOL
      occurred in 6.0% in the myopic group and 4.8% in the toric group. Risk factors
      for increased EC loss were a shallow anterior chamber depth (ACD) (P </= 0.005)
      and a smaller distance between the central and peripheral pIOL edge to the
      endothelium (P </= 0.005). CONCLUSIONS: A significant linear chronic EC loss was 
      reported after implantation with myopic or toric iris-fixated pIOLs. A smaller
      ACD and smaller distance between pIOL edge and endothelium were risk factors for 
      EC loss. Modification of preoperative age-related ECD thresholds is indicated to 
      maintain an ECD that warrants safe future combined pIOL explantation and cataract
      surgery.
CI  - Copyright (c) 2017 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Jonker, Soraya M R
AU  - Jonker SMR
AD  - University Eye Clinic Maastricht, Maastricht University Medical Center,
      Maastricht, The Netherlands. Electronic address: soraya.jonker@mumc.nl.
FAU - Berendschot, Tos T J M
AU  - Berendschot TTJM
AD  - University Eye Clinic Maastricht, Maastricht University Medical Center,
      Maastricht, The Netherlands.
FAU - Ronden, Annick E
AU  - Ronden AE
AD  - University Eye Clinic Maastricht, Maastricht University Medical Center,
      Maastricht, The Netherlands.
FAU - Saelens, Isabelle E Y
AU  - Saelens IEY
AD  - University Eye Clinic Maastricht, Maastricht University Medical Center,
      Maastricht, The Netherlands.
FAU - Bauer, Noel J C
AU  - Bauer NJC
AD  - University Eye Clinic Maastricht, Maastricht University Medical Center,
      Maastricht, The Netherlands.
FAU - Nuijts, Rudy M M A
AU  - Nuijts RMMA
AD  - University Eye Clinic Maastricht, Maastricht University Medical Center,
      Maastricht, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20170919
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
EDAT- 2017/09/25 06:00
MHDA- 2017/09/25 06:00
CRDT- 2017/09/23 06:00
PHST- 2017/05/17 00:00 [received]
PHST- 2017/07/10 00:00 [revised]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2017/09/25 06:00 [medline]
PHST- 2017/09/23 06:00 [entrez]
AID - S0161-6420(17)31290-3 [pii]
AID - 10.1016/j.ophtha.2017.08.011 [doi]
PST - ppublish
SO  - Ophthalmology. 2018 Apr;125(4):486-494. doi: 10.1016/j.ophtha.2017.08.011. Epub
      2017 Sep 19.