PMID- 28931240
OWN - NLM
STAT- MEDLINE
DCOM- 20170928
LR  - 20181005
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 216
IP  - 4
DP  - 2017 Aug 15
TI  - Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a
      Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed
      Influenza Virus Infections.
PG  - 415-424
LID - 10.1093/infdis/jix268 [doi]
AB  - Background: Data on the relative contribution of influenza virus and other
      respiratory pathogens to respiratory infections in community-dwelling older
      adults (>/=60 years) are needed. Methods: A prospective observational cohort
      study was performed in the Netherlands during 2 winters. Nasopharyngeal and
      oropharyngeal swabs were collected during influenza-like illness (ILI) episodes
      and from controls. Viruses and bacteria were identified by multiplex
      ligation-dependent probe amplification assay and conventional bacterial culture. 
      Results: The ILI incidence in the consecutive seasons was 7.2% and 11.6%, and
      influenza virus caused 18.9% and 34.2% of ILI episodes. Potential pathogen were
      detected in 80% of the ILI events with influenza virus, coronaviruses,
      rhinoviruses, human metapneumovirus, respiratory syncytial virus, parainfluenza
      viruses, and Haemophilus influenzae being the most common. Influenza vaccination 
      reduced influenza virus infection by 73% (95% confidence interval [CI], 26%-90%) 
      and 51% (95% CI, 7%-74%) in ILI patients. However, ILI incidence was similar
      between vaccinated (7.6% and 10.8%) and nonvaccinated (4.2% and 11.4%)
      participants in 2011-2012 and 2012-2013, respectively (P > .05). Conclusions:
      Influenza virus is a frequent pathogen in older adults with ILI. Vaccination
      reduces the number of influenza virus infections but not the overall number of
      ILI episodes: other pathogens fill the gap. We suggest the existence of a pool of
      individuals with high susceptibility to respiratory infections. Clinical Trials
      Registration: NTR3386.
CI  - (c) The Author 2017. Published by Oxford University Press for the Infectious
      Diseases Society of America. All rights reserved. For permissions, e-mail:
      journals.permissions@oup.com.
FAU - van Beek, Josine
AU  - van Beek J
AD  - Centre for Infectious Disease Control, National Institute for Public Health and
      the Environment, Bilthoven.
FAU - Veenhoven, Reinier H
AU  - Veenhoven RH
AD  - Spaarne Gasthuis Academy, Hoofddorp.
FAU - Bruin, Jacob P
AU  - Bruin JP
AD  - Regional Laboratory for Public Health Kennemerland, Haarlem.
FAU - van Boxtel, Renee A J
AU  - van Boxtel RAJ
AD  - Centre for Infectious Disease Control, National Institute for Public Health and
      the Environment, Bilthoven.
FAU - de Lange, Marit M A
AU  - de Lange MMA
AD  - Centre for Infectious Disease Control, National Institute for Public Health and
      the Environment, Bilthoven.
FAU - Meijer, Adam
AU  - Meijer A
AD  - Centre for Infectious Disease Control, National Institute for Public Health and
      the Environment, Bilthoven.
FAU - Sanders, Elisabeth A M
AU  - Sanders EAM
AD  - Centre for Infectious Disease Control, National Institute for Public Health and
      the Environment, Bilthoven.
AD  - Department of Pedriatric Immunology and Infectious Diseases, Wilhelmina
      Children's Hospital/University Medical Center, Utrecht, The Netherlands.
FAU - Rots, Nynke Y
AU  - Rots NY
AD  - Centre for Infectious Disease Control, National Institute for Public Health and
      the Environment, Bilthoven.
FAU - Luytjes, Willem
AU  - Luytjes W
AD  - Centre for Infectious Disease Control, National Institute for Public Health and
      the Environment, Bilthoven.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Influenza Vaccines)
SB  - AIM
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Independent Living
MH  - Influenza Vaccines/administration & dosage/*therapeutic use
MH  - Influenza, Human/*epidemiology/prevention & control
MH  - Male
MH  - Middle Aged
MH  - Multiplex Polymerase Chain Reaction
MH  - Nasopharynx/virology
MH  - Netherlands/epidemiology
MH  - Prospective Studies
MH  - Respiratory Tract Infections/*epidemiology/prevention & control
MH  - Seasons
MH  - *Vaccination
OTO - NOTNLM
OT  - *influenza virus
OT  - *influenza virus infection
OT  - *influenza-like illness
OT  - *older adults
OT  - *vaccination
EDAT- 2017/09/22 06:00
MHDA- 2017/09/29 06:00
CRDT- 2017/09/22 06:00
PHST- 2017/02/24 00:00 [received]
PHST- 2017/06/01 00:00 [accepted]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/29 06:00 [medline]
AID - 3958807 [pii]
AID - 10.1093/infdis/jix268 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Aug 15;216(4):415-424. doi: 10.1093/infdis/jix268.