PMID- 28917404
OWN - NLM
STAT- In-Data-Review
LR  - 20170917
IS  - 1873-4502 (Electronic)
IS  - 0886-3350 (Linking)
VI  - 43
IP  - 8
DP  - 2017 Aug
TI  - Clinical course and outcomes in patients with Mooren ulcer who had cataract
      surgery.
PG  - 1044-1049
LID - S0886-3350(17)30494-7 [pii]
LID - 10.1016/j.jcrs.2017.05.034 [doi]
AB  - PURPOSE: To report outcomes of cataract surgery in patients with Mooren ulcer.
      SETTING: L.V. Prasad Eye Institute, Hyderabad, India. DESIGN: Retrospective case 
      series. METHODS: The medical records of patients with Mooren ulcer who had
      cataract surgery between 2000 and 2015 were assessed. The main outcome measures
      were the role of preoperative immunosuppression and disease inactivity, cataract 
      surgery safety, visual outcomes, and postoperative ulcer recurrence. RESULTS: Of 
      22 patients (26 eyes), the mean corneal ulceration was 6.8 clock hours +/- 2.9
      (SD). Corticosteroids were the most commonly used (84.6% of the 26 eyes)
      preoperative immunosuppression agents and 38.5% of the 26 eyes were under
      maintenance immunosuppression. The median disease inactivity before surgery was 7
      months. Cataract surgery was extracapsular in 10 patients, small incision in 3
      patients, and phacoemulsification in 13 patients. Twenty-two eyes had scleral
      incisions. The median follow-up was 6 months (interquartile range, 10 months).
      The median corrected distance visual acuity (CDVA) improved from 1.48 logarithm
      of minimum angle of resolution (logMAR) before surgery to 0.30 and 0.35 logMAR at
      1 month and at the last follow-up after surgery, respectively (P </= .0001).
      Mooren ulcer recurred in 5 eyes between 3 months and 7 years after surgery. No
      disease activity was seen in the immediate postoperative period. No significant
      risk factors for disease recurrence were noted. CONCLUSIONS: With adequate
      immunosuppression, cataract surgery in eyes with Mooren ulcer was safe and CDVA
      improved significantly with no disease reactivation immediately after surgery. No
      proven role of maintenance immunosuppression was observed. The type of cataract
      surgery had no influence on ulcer reactivation. Patients with a disease-free
      interval of 6 months or more before surgery and those who had scleral incisions
      had favorable outcomes.
CI  - Copyright (c) 2017 ASCRS and ESCRS. Published by Elsevier Inc. All rights
      reserved.
FAU - Das, Shilpa
AU  - Das S
AD  - From the Prof. Brien Holden Eye Research Centre (Das), Ophthalmic Biophysics
      (Mohamed), and the Cornea, Ocular Immunology and Uveitis Service, L.V. Prasad Eye
      Institute, Hyderabad, Telangana, India.
FAU - Mohamed, Ashik
AU  - Mohamed A
AD  - From the Prof. Brien Holden Eye Research Centre (Das), Ophthalmic Biophysics
      (Mohamed), and the Cornea, Ocular Immunology and Uveitis Service, L.V. Prasad Eye
      Institute, Hyderabad, Telangana, India.
FAU - Sangwan, Virender S
AU  - Sangwan VS
AD  - From the Prof. Brien Holden Eye Research Centre (Das), Ophthalmic Biophysics
      (Mohamed), and the Cornea, Ocular Immunology and Uveitis Service, L.V. Prasad Eye
      Institute, Hyderabad, Telangana, India. Electronic address: vsangwan@lvpei.org.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
EDAT- 2017/09/18 06:00
MHDA- 2017/09/18 06:00
CRDT- 2017/09/18 06:00
PHST- 2016/12/09 00:00 [received]
PHST- 2017/05/07 00:00 [revised]
PHST- 2017/05/21 00:00 [accepted]
PHST- 2017/09/18 06:00 [entrez]
PHST- 2017/09/18 06:00 [pubmed]
PHST- 2017/09/18 06:00 [medline]
AID - S0886-3350(17)30494-7 [pii]
AID - 10.1016/j.jcrs.2017.05.034 [doi]
PST - ppublish
SO  - J Cataract Refract Surg. 2017 Aug;43(8):1044-1049. doi:
      10.1016/j.jcrs.2017.05.034.