PMID- 28910359
OWN - NLM
STAT- MEDLINE
DCOM- 20171013
LR  - 20171013
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 9
DP  - 2017
TI  - Prevalence and determinants of oral infection by Human Papillomavirus in
      HIV-infected and uninfected men who have sex with men.
PG  - e0184623
LID - 10.1371/journal.pone.0184623 [doi]
AB  - BACKGROUND: Oral Human Papillomavirus (HPV) infection is rare in the general
      population but common in high-risk individuals. Recent data indicate that oral
      HPV is associated with the development of head and neck carcinomas. HPV16
      infection, in particular, increases the risk of oropharyngeal cancer. METHODS: We
      evaluated oral HPV prevalence and determinants of infection in cancer-free
      HIV-infected and uninfected men who have sex with men (MSM) recruited among
      attendees of an STI/HIV centre. Oral rinse and gargles were collected using a
      mouthwash and analyzed with the Linear Array HPV Genotyping Test.
      Socio-demographic and behavioral data were collected through face-to-face
      interviews. RESULTS: Overall, 170 MSM participated: 98 HIV-uninfected and 72
      HIV-infected (91.7% under cART). Oral HPV was detected in 17.3% and 27.8% of the 
      subjects, respectively (p = 0.13). Non-carcinogenic HPVs were significantly more 
      common among HIV-infected MSM (18.1% vs. 5.1%, p = 0.01). Prevalence of the HPV
      types included in the quadrivalent HPV vaccine was similar (6.1% vs. 8.3% for the
      HIV-negative and positive MSM, respectively, p = 0.76). HPV16 was the most
      frequent type in HIV-negative (5.1%), and HIV-positive individuals, in the latter
      group together with HPV18, 72 and 84 (4.2% each). Older age at first sex (AOR:
      4.02, 95% CI: 1.17-13.86 for those older than 18 years of age at first
      intercourse, p = 0.027) and a higher lifetime number of receptive oral sex
      partners (AOR: 9.14, 95% CI: 2.49-33.62 for those with >50 compared to </=50
      partners, p<0.001) were determinants of oral HPV among HIV-infected MSM.
      CONCLUSION: Oral HPV infection among MSM attending an urban STI center is very
      frequent compared to the general population. Sexual behavior appears to be the
      major determinant of infection among the HIV-infected individuals.
FAU - Rollo, Francesca
AU  - Rollo F
AD  - Pathology Department, Regina Elena National Cancer Institute, IFO, IRCCS, Rome,
      Italy.
FAU - Latini, Alessandra
AU  - Latini A
AD  - STI/HIV Unit, San Gallicano Dermatologic Institute, IFO, IRCCS, Rome, Italy.
FAU - Pichi, Barbara
AU  - Pichi B
AD  - Otolaryngology Head Neck Surgery Department, Regina Elena National Cancer
      Institute, IFO, IRCCS, Rome, Italy.
FAU - Colafigli, Manuela
AU  - Colafigli M
AD  - STI/HIV Unit, San Gallicano Dermatologic Institute, IFO, IRCCS, Rome, Italy.
FAU - Benevolo, Maria
AU  - Benevolo M
AD  - Pathology Department, Regina Elena National Cancer Institute, IFO, IRCCS, Rome,
      Italy.
FAU - Sinopoli, Ilenia
AU  - Sinopoli I
AD  - Otolaryngology Head Neck Surgery Department, Regina Elena National Cancer
      Institute, IFO, IRCCS, Rome, Italy.
FAU - Sperduti, Isabella
AU  - Sperduti I
AD  - Biostatistics Unit, Regina Elena National Cancer Institute, IFO, IRCCS, Rome,
      Italy.
FAU - Laquintana, Valentina
AU  - Laquintana V
AD  - Pathology Department, Regina Elena National Cancer Institute, IFO, IRCCS, Rome,
      Italy.
FAU - Fabbri, Giulia
AU  - Fabbri G
AD  - Pathology Department, Regina Elena National Cancer Institute, IFO, IRCCS, Rome,
      Italy.
FAU - Frasca, Mirko
AU  - Frasca M
AD  - STI/HIV Unit, San Gallicano Dermatologic Institute, IFO, IRCCS, Rome, Italy.
FAU - Cristaudo, Antonio
AU  - Cristaudo A
AD  - STI/HIV Unit, San Gallicano Dermatologic Institute, IFO, IRCCS, Rome, Italy.
FAU - Giuliani, Massimo
AU  - Giuliani M
AD  - STI/HIV Unit, San Gallicano Dermatologic Institute, IFO, IRCCS, Rome, Italy.
FAU - Dona, Maria Gabriella
AU  - Dona MG
AUID- ORCID: http://orcid.org/0000-0003-3250-1726
AD  - STI/HIV Unit, San Gallicano Dermatologic Institute, IFO, IRCCS, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170914
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Coinfection/*epidemiology/virology
MH  - Cross-Sectional Studies
MH  - Genotype
MH  - HIV Infections/*complications
MH  - Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Diseases/epidemiology/*virology
MH  - Papillomaviridae/*genetics
MH  - Papillomavirus Infections/*epidemiology
MH  - Prevalence
MH  - Sexual Behavior
PMC - PMC5599005
EDAT- 2017/09/15 06:00
MHDA- 2017/10/14 06:00
CRDT- 2017/09/15 06:00
PHST- 2017/05/29 00:00 [received]
PHST- 2017/08/28 00:00 [accepted]
PHST- 2017/09/15 06:00 [entrez]
PHST- 2017/09/15 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
AID - 10.1371/journal.pone.0184623 [doi]
AID - PONE-D-17-20534 [pii]
PST - epublish
SO  - PLoS One. 2017 Sep 14;12(9):e0184623. doi: 10.1371/journal.pone.0184623.
      eCollection 2017.