PMID- 28902869
OWN - NLM
STAT- MEDLINE
DCOM- 20171031
LR  - 20171031
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 9
DP  - 2017
TI  - High mortality rates in men initiated on anti-retroviral treatment in
      KwaZulu-Natal, South Africa.
PG  - e0184124
LID - 10.1371/journal.pone.0184124 [doi]
AB  - In attaining UNAIDS targets of 90-90-90 to achieve epidemic control,
      understanding who the current utilizers of HIV treatment services are will inform
      efforts aimed at reaching those not being reached. A retrospective chart review
      of CAPRISA AIDS Treatment Program (CAT) patients between 2004 and 2013 was
      undertaken. Of the 4043 HIV-infected patients initiated on ART, 2586 (64.0%) were
      women. At ART initiation, men, compared to women, had significantly lower median 
      CD4+ cell counts (113 vs 131 cells/mm3, p <0.001), lower median body mass index
      (BMI) (21.0 vs 24.2 kg/m2, p<0.001), higher mean log viral load (5.0 vs 4.9
      copies/ml, p<0.001) and were significantly older (median age: 35 vs. 32 years,
      p<0.001). Men had higher mortality rates compared to women, 6.7 per 100
      person-years (p-y), (95% CI: 5.8-7.8) vs. 4.4 per 100 p-y, (95% CI: 3.8-5.0);
      mortality rate ratio: 1.54, (95% CI: 1.27-1.87), p <0.001. Age-standardised
      mortality rate was 7.9 per 100 p-y (95% CI: 4.1-11.7) for men and 5.7 per 100 p-y
      (95% CI: 2.7 to 8.6) for women (standardised mortality ratio: 1.38 (1.15 to
      1.70)). Mean CD4+ cell count increases post-ART initiation were lower in men at
      all follow-up time points. Men presented later in the course of their HIV disease
      for ART initiation with more advanced disease and experienced a higher mortality 
      rate compared to women.
FAU - Naidoo, Kogieleum
AU  - Naidoo K
AUID- ORCID: http://orcid.org/0000-0002-8874-6661
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
AD  - MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical
      Research Institute, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South
      Africa.
FAU - Hassan-Moosa, Razia
AU  - Hassan-Moosa R
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
FAU - Yende-Zuma, Nonhlanhla
AU  - Yende-Zuma N
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
AD  - MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical
      Research Institute, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South
      Africa.
FAU - Govender, Dhineshree
AU  - Govender D
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
FAU - Padayatchi, Nesri
AU  - Padayatchi N
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
AD  - MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical
      Research Institute, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South
      Africa.
FAU - Dawood, Halima
AU  - Dawood H
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
FAU - Adams, Rochelle Nicola
AU  - Adams RN
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
FAU - Govender, Aveshen
AU  - Govender A
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
FAU - Chinappa, Tilagavathy
AU  - Chinappa T
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
FAU - Abdool-Karim, Salim
AU  - Abdool-Karim S
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
AD  - MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical
      Research Institute, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South
      Africa.
AD  - Mailman School of Public Health, Department of Epidemiology, Columbia University,
      New York, New York, United States of America.
FAU - Abdool-Karim, Quarraisha
AU  - Abdool-Karim Q
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      KwaZulu-Natal, South Africa.
AD  - Mailman School of Public Health, Department of Epidemiology, Columbia University,
      New York, New York, United States of America.
LA  - eng
GR  - D43 TW000231/TW/FIC NIH HHS/United States
GR  - UM1 AI069469/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20170913
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adult
MH  - Anti-HIV Agents/*therapeutic use
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Female
MH  - HIV Infections/*drug therapy/*mortality
MH  - HIV-1
MH  - Humans
MH  - Male
MH  - Mortality
MH  - Retrospective Studies
MH  - Sex Factors
MH  - South Africa/epidemiology
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC5597205
EDAT- 2017/09/14 06:00
MHDA- 2017/11/01 06:00
CRDT- 2017/09/14 06:00
PHST- 2017/06/14 00:00 [received]
PHST- 2017/08/18 00:00 [accepted]
PHST- 2017/09/14 06:00 [entrez]
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2017/11/01 06:00 [medline]
AID - 10.1371/journal.pone.0184124 [doi]
AID - PONE-D-17-22444 [pii]
PST - epublish
SO  - PLoS One. 2017 Sep 13;12(9):e0184124. doi: 10.1371/journal.pone.0184124.
      eCollection 2017.