PMID- 28902679
OWN - NLM
STAT- MEDLINE
DCOM- 20170925
LR  - 20180223
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 76
IP  - 2
DP  - 2017 Oct 1
TI  - Brief Report: Peripheral Monocyte/Macrophage Phenotypes Associated With the
      Evolution of Cognitive Performance in HIV-Infected Patients.
PG  - 219-224
LID - 10.1097/QAI.0000000000001480 [doi]
AB  - BACKGROUND: The contribution of monocyte activation in the development of
      HIV-associated neurocognitive disorders is not completely understood. This study 
      aimed to explore the predictive value of peripheral monocyte/macrophage (M/M)
      phenotypes on the evolution of cognitive performance in a population of
      virologically suppressed HIV-infected patients. SETTING: Prospective,
      observational, longitudinal study. METHODS: HIV-1-infected patients with HIV-RNA 
      <50copies/mL for >12 months underwent neuropsychological examination at baseline 
      and after 1 year. Cognitive performance was evaluated using Z-transformed scores,
      and neurocognitive impairment (NCI) was defined according to Frascati criteria.
      Peripheral M/M phenotypes (classic CD14CD16, intermediate CD14CD16, and
      nonclassic CD14CD16) and specific surface activation markers (eg, CD163, CD11b,
      and CD38) were evaluated using flow cytometry at baseline. Predictive value of
      peripheral M/M phenotypes on the evolution of cognitive performance over 1-year
      follow-up was also evaluated. RESULTS: Overall, 54 patients [85.2% men, median
      age 50 years (range 27-60 years), 27.8% hepatitis C virus coinfected, 48.1% with 
      past AIDS-defining events, median nadir CD4 83 cells/muL (range 1-334), median
      baseline CD4 547 cells/muL (range 136-1652)] were enrolled. Proportion of
      patients with NCI was low, accounting for 13% at baseline and 16.5% after 1 year 
      (P = 0.687). Memory was the only single domain in which decreased performance
      after 1 year was observed (-0.25 Z-score, P = 0.025). In patients with
      significant decrease (>/=0.5 SD) in memory performance (n = 20), significantly
      lower CD14CD16CD163 (% CD14CD16) (P = 0.038) and higher CD14CD38 (% CD14) (P =
      0.030) levels were observed. CONCLUSIONS: In virologically suppressed
      HIV-infected patients, the evolution of memory performance could be linked to the
      expression of certain peripheral activated M/M phenotypes. Such associations
      should be verified in larger populations over the long term.
FAU - Fabbiani, Massimiliano
AU  - Fabbiani M
AD  - *Division of Infectious Diseases, Department of Internal Medicine, San Gerardo
      Hospital, University of Milano-Bicocca, Monza, Italy; daggerApheresis Unit,
      Transfusion Medicine Service, San Gerardo Hospital, Monza, Italy; and double
      daggerUnit of Clinical Psychology, San Gerardo Hospital, Monza, Italy.
FAU - Muscatello, Antonio
AU  - Muscatello A
FAU - Perseghin, Paolo
AU  - Perseghin P
FAU - Bani, Marco
AU  - Bani M
FAU - Incontri, Arianna
AU  - Incontri A
FAU - Squillace, Nicola
AU  - Squillace N
FAU - Lapadula, Giuseppe
AU  - Lapadula G
FAU - Gori, Andrea
AU  - Gori A
FAU - Bandera, Alessandra
AU  - Bandera A
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Biomarkers)
SB  - IM
SB  - X
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/metabolism
MH  - *Cognition
MH  - Cognition Disorders/*complications/virology
MH  - Cross-Sectional Studies
MH  - Endpoint Determination
MH  - Evolution, Molecular
MH  - Female
MH  - HIV Infections/*complications
MH  - Humans
MH  - Longitudinal Studies
MH  - Macrophages/*cytology
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*cytology
MH  - Phenotype
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2017/09/14 06:00
MHDA- 2017/09/26 06:00
CRDT- 2017/09/14 06:00
PHST- 2017/09/14 06:00 [entrez]
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2017/09/26 06:00 [medline]
AID - 10.1097/QAI.0000000000001480 [doi]
AID - 00126334-201710010-00017 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2017 Oct 1;76(2):219-224. doi:
      10.1097/QAI.0000000000001480.