PMID- 28892736
OWN - NLM
STAT- MEDLINE
DCOM- 20171109
LR  - 20171221
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 512
DP  - 2017 Dec
TI  - Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses
      affected Japan during the winter of 2016-2017.
PG  - 8-20
LID - S0042-6822(17)30295-7 [pii]
LID - 10.1016/j.virol.2017.08.035 [doi]
AB  - To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6
      highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during
      winter 2016-2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic
      analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected
      poultry and wild birds during that period. Japanese H5N6 isolates shared a common
      genetic ancestor in 6 of 8 genomic segments, and the PA and NS genes demonstrated
      4 and 2 genetic origins, respectively. Six gene segments originated from a
      putative ancestral clade 2.3.4.4 H5N6 virus that was a possible genetic
      reassortant among Chinese clade 2.3.4.4 H5N6 HPAIVs. In addition, 2 NS clusters
      and a PA cluster in Japanese H5N6 HPAIVs originated from Chinese HPAIVs, whereas 
      3 distinct AIV-derived PA clusters were evident. These results suggest that
      migratory birds were important in the spread and genetic diversification of clade
      2.3.4.4 H5 HPAIVs.
CI  - Copyright (c) 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Takemae, Nobuhiro
AU  - Takemae N
AD  - Division of Transboundary Animal Disease, National Institute of Animal Health,
      NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan; Thailand-Japan Zoonotic 
      Diseases Collaboration Center, Kasetklang, Chatuchak, Bangkok 10900, Thailand.
FAU - Tsunekuni, Ryota
AU  - Tsunekuni R
AD  - Division of Transboundary Animal Disease, National Institute of Animal Health,
      NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan; Thailand-Japan Zoonotic 
      Diseases Collaboration Center, Kasetklang, Chatuchak, Bangkok 10900, Thailand.
FAU - Sharshov, Kirill
AU  - Sharshov K
AD  - Research Institute of Experimental and Clinical Medicine, 2, Timakova street,
      Novosibirsk 630117, Russia.
FAU - Tanikawa, Taichiro
AU  - Tanikawa T
AD  - Division of Transboundary Animal Disease, National Institute of Animal Health,
      NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan; Thailand-Japan Zoonotic 
      Diseases Collaboration Center, Kasetklang, Chatuchak, Bangkok 10900, Thailand.
FAU - Uchida, Yuko
AU  - Uchida Y
AD  - Division of Transboundary Animal Disease, National Institute of Animal Health,
      NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan; Thailand-Japan Zoonotic 
      Diseases Collaboration Center, Kasetklang, Chatuchak, Bangkok 10900, Thailand.
FAU - Ito, Hiroshi
AU  - Ito H
AD  - The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University,
      4-101 Koyama-cho Minami, Tottori, Tottori 680-8550, Japan.
FAU - Soda, Kosuke
AU  - Soda K
AD  - The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University,
      4-101 Koyama-cho Minami, Tottori, Tottori 680-8550, Japan.
FAU - Usui, Tatsufumi
AU  - Usui T
AD  - The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University,
      4-101 Koyama-cho Minami, Tottori, Tottori 680-8550, Japan.
FAU - Sobolev, Ivan
AU  - Sobolev I
AD  - Research Institute of Experimental and Clinical Medicine, 2, Timakova street,
      Novosibirsk 630117, Russia.
FAU - Shestopalov, Alexander
AU  - Shestopalov A
AD  - Research Institute of Experimental and Clinical Medicine, 2, Timakova street,
      Novosibirsk 630117, Russia.
FAU - Yamaguchi, Tsuyoshi
AU  - Yamaguchi T
AD  - The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University,
      4-101 Koyama-cho Minami, Tottori, Tottori 680-8550, Japan.
FAU - Mine, Junki
AU  - Mine J
AD  - Division of Transboundary Animal Disease, National Institute of Animal Health,
      NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan; Thailand-Japan Zoonotic 
      Diseases Collaboration Center, Kasetklang, Chatuchak, Bangkok 10900, Thailand.
FAU - Ito, Toshihiro
AU  - Ito T
AD  - The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University,
      4-101 Koyama-cho Minami, Tottori, Tottori 680-8550, Japan.
FAU - Saito, Takehiko
AU  - Saito T
AD  - Division of Transboundary Animal Disease, National Institute of Animal Health,
      NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan; Thailand-Japan Zoonotic 
      Diseases Collaboration Center, Kasetklang, Chatuchak, Bangkok 10900, Thailand;
      United Graduate School of Veterinary Sciences, Gifu University, 1-1, Yanagito,
      Gifu, Gifu 501-1112, Japan. Electronic address: taksaito@affrc.go.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170909
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
SB  - IM
MH  - Animals
MH  - *Chickens
MH  - Genetic Variation
MH  - Influenza A virus/*genetics/*isolation & purification
MH  - Influenza in Birds/epidemiology/*virology
MH  - Japan/epidemiology
MH  - Phylogeny
MH  - Reassortant Viruses/*genetics/isolation & purification
OTO - NOTNLM
OT  - *Clade 2.3.4.4
OT  - *H5N6
OT  - *Highly pathogenic avian influenza A viruses
OT  - *Poultry
OT  - *Wild bird
EDAT- 2017/09/12 06:00
MHDA- 2017/11/10 06:00
CRDT- 2017/09/12 06:00
PHST- 2017/06/28 00:00 [received]
PHST- 2017/08/22 00:00 [revised]
PHST- 2017/08/24 00:00 [accepted]
PHST- 2017/09/12 06:00 [pubmed]
PHST- 2017/11/10 06:00 [medline]
PHST- 2017/09/12 06:00 [entrez]
AID - S0042-6822(17)30295-7 [pii]
AID - 10.1016/j.virol.2017.08.035 [doi]
PST - ppublish
SO  - Virology. 2017 Dec;512:8-20. doi: 10.1016/j.virol.2017.08.035. Epub 2017 Sep 9.