PMID- 28873402
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20190329
IS  - 1553-7404 (Electronic)
IS  - 1553-7390 (Linking)
VI  - 13
IP  - 9
DP  - 2017 Sep
TI  - Gene-environment interaction study for BMI reveals interactions between genetic
      factors and physical activity, alcohol consumption and socioeconomic status.
PG  - e1006977
LID - 10.1371/journal.pgen.1006977 [doi]
AB  - Previous genome-wide association studies (GWAS) have identified hundreds of
      genetic loci to be associated with body mass index (BMI) and risk of obesity.
      Genetic effects can differ between individuals depending on lifestyle or
      environmental factors due to gene-environment interactions. In this study, we
      examine gene-environment interactions in 362,496 unrelated participants with
      Caucasian ancestry from the UK Biobank resource. A total of 94 BMI-associated
      SNPs, selected from a previous GWAS on BMI, were used to construct weighted
      genetic scores for BMI (GSBMI). Linear regression modeling was used to estimate
      the effect of gene-environment interactions on BMI for 131 lifestyle factors
      related to: dietary habits, smoking and alcohol consumption, physical activity,
      socioeconomic status, mental health, sleeping patterns, as well as
      female-specific factors such as menopause and childbirth. In total, 15 lifestyle 
      factors were observed to interact with GSBMI, of which alcohol intake frequency, 
      usual walking pace, and Townsend deprivation index, a measure of socioeconomic
      status, were all highly significant (p = 1.45*10-29, p = 3.83*10-26, p =
      4.66*10-11, respectively). Interestingly, the frequency of alcohol consumption,
      rather than the total weekly amount resulted in a significant interaction. The
      FTO locus was the strongest single locus interacting with any of the lifestyle
      factors. However, 13 significant interactions were also observed after omitting
      the FTO locus from the genetic score. Our analyses indicate that many lifestyle
      factors modify the genetic effects on BMI with some groups of individuals having 
      more than double the effect of the genetic score. However, the underlying causal 
      mechanisms of gene-environmental interactions are difficult to deduce from
      cross-sectional data alone and controlled experiments are required to fully
      characterise the causal factors.
FAU - Rask-Andersen, Mathias
AU  - Rask-Andersen M
AUID- ORCID: http://orcid.org/0000-0002-8008-4659
AD  - Department of Immunology, Genetics and Pathology, Science for Life Laboratory,
      Uppsala University, Uppsala, Sweden.
FAU - Karlsson, Torgny
AU  - Karlsson T
AD  - Department of Immunology, Genetics and Pathology, Science for Life Laboratory,
      Uppsala University, Uppsala, Sweden.
FAU - Ek, Weronica E
AU  - Ek WE
AD  - Department of Immunology, Genetics and Pathology, Science for Life Laboratory,
      Uppsala University, Uppsala, Sweden.
FAU - Johansson, Asa
AU  - Johansson A
AUID- ORCID: http://orcid.org/0000-0002-2915-4498
AD  - Department of Immunology, Genetics and Pathology, Science for Life Laboratory,
      Uppsala University, Uppsala, Sweden.
LA  - eng
GR  - MC_PC_12027/Medical Research Council/United Kingdom
GR  - MC_QA137853/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20170905
PL  - United States
TA  - PLoS Genet
JT  - PLoS genetics
JID - 101239074
SB  - IM
MH  - Aged
MH  - Alcohol Drinking/genetics
MH  - *Body Mass Index
MH  - European Continental Ancestry Group
MH  - Exercise
MH  - Female
MH  - *Gene-Environment Interaction
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*genetics/physiopathology
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Smoking
MH  - Social Class
PMC - PMC5600404
EDAT- 2017/09/06 06:00
MHDA- 2017/10/11 06:00
CRDT- 2017/09/06 06:00
PHST- 2017/01/13 00:00 [received]
PHST- 2017/08/13 00:00 [accepted]
PHST- 2017/09/15 00:00 [revised]
PHST- 2017/09/06 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2017/09/06 06:00 [entrez]
AID - 10.1371/journal.pgen.1006977 [doi]
AID - PGENETICS-D-17-00077 [pii]
PST - epublish
SO  - PLoS Genet. 2017 Sep 5;13(9):e1006977. doi: 10.1371/journal.pgen.1006977.
      eCollection 2017 Sep.