PMID- 28869671
OWN - NLM
STAT- MEDLINE
DCOM- 20171030
LR  - 20171030
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 82
IP  - 4
DP  - 2017 Oct
TI  - Concussion in adolescence and risk of multiple sclerosis.
PG  - 554-561
LID - 10.1002/ana.25036 [doi]
AB  - OBJECTIVE: To assess whether concussion in childhood or adolescence is associated
      with subsequent multiple sclerosis (MS) risk. Previous research suggests an
      association, but methodological limitations included retrospective data
      collection and small study populations. METHODS: The national Swedish Patient
      Register (hospital diagnoses) and MS Register were used to identify all MS
      diagnoses up to 2012 among people born since 1964, when the Patient Register was 
      established. The 7,292 patients with MS were matched individually with 10 people 
      without MS by sex, year of birth, age/vital status at MS diagnosis, and region of
      residence (county), resulting in a study population of 80,212. Diagnoses of
      concussion and control diagnoses of broken limb bones were identified using the
      Patient Register from birth to age 10 years or from age 11 to 20 years.
      Conditional logistic regression was used to examine associations with MS.
      RESULTS: Concussion in adolescence was associated with a raised risk of MS,
      producing adjusted odds ratios (95% confidence intervals) of 1.22 (1.05-1.42, p =
      0.008) and 2.33 (1.35-4.04, p = 0.002) for 1 diagnosis of concussion and >1
      diagnosis of concussion, respectively, compared with none. No notable association
      with MS was observed for concussion in childhood, or broken limb bones in
      childhood and adolescence. INTERPRETATION: Head trauma in adolescence,
      particularly if repeated, is associated with a raised risk of future MS, possibly
      due to initiation of an autoimmune process in the central nervous system. This
      further emphasizes the importance of protecting young people from head injuries. 
      Ann Neurol 2017;82:554-561.
CI  - (c) 2017 American Neurological Association.
FAU - Montgomery, Scott
AU  - Montgomery S
AD  - Clinical Epidemiology and Biostatistics, School of Medical Sciences, Orebro
      University, Orebro, Sweden.
AD  - Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, 
      Sweden.
AD  - Department of Epidemiology and Public Health, University College London, London, 
      United Kingdom.
FAU - Hiyoshi, Ayako
AU  - Hiyoshi A
AD  - Clinical Epidemiology and Biostatistics, School of Medical Sciences, Orebro
      University, Orebro, Sweden.
FAU - Burkill, Sarah
AU  - Burkill S
AD  - Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, 
      Sweden.
AD  - Center for Pharmacoepidemiology, Department of Medicine, Karolinska Institute,
      Solna, Sweden.
FAU - Alfredsson, Lars
AU  - Alfredsson L
AD  - Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
AD  - Center for Occupational and Environmental Medicine, Stockholm County Council,
      Stockholm, Sweden.
FAU - Bahmanyar, Shahram
AU  - Bahmanyar S
AD  - Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, 
      Sweden.
AD  - Center for Pharmacoepidemiology, Department of Medicine, Karolinska Institute,
      Solna, Sweden.
FAU - Olsson, Tomas
AU  - Olsson T
AD  - Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska
      Institute, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20170925
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Concussion/*complications/epidemiology
MH  - Child
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnosis/*epidemiology/*etiology
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sweden/epidemiology
MH  - Young Adult
EDAT- 2017/09/05 06:00
MHDA- 2017/10/31 06:00
CRDT- 2017/09/05 06:00
PHST- 2017/05/15 00:00 [received]
PHST- 2017/08/28 00:00 [revised]
PHST- 2017/08/28 00:00 [accepted]
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2017/10/31 06:00 [medline]
PHST- 2017/09/05 06:00 [entrez]
AID - 10.1002/ana.25036 [doi]
PST - ppublish
SO  - Ann Neurol. 2017 Oct;82(4):554-561. doi: 10.1002/ana.25036. Epub 2017 Sep 25.