PMID- 28858963
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20171016
IS  - 1531-7021 (Electronic)
IS  - 1040-8738 (Linking)
VI  - 28
IP  - 6
DP  - 2017 Nov
TI  - IgG4-related disease in the eye and ocular adnexa.
PG  - 617-622
LID - 10.1097/ICU.0000000000000427 [doi]
AB  - PURPOSE OF REVIEW: IgG4-related disease is a multi-organ fibro-inflammatory
      disease with characteristic histopathology showing lymphoplasmacytic
      infiltration, increased IgG4+ plasma cells and elevated IgG4/IgG ratios (>40%).
      The lacrimal gland is the most common ocular site of involvement. Scleritis and
      intraocular involvement in IgG4-related ophthalmic disease (IgG4-ROD) have
      recently been reported. The purpose of this review is to describe orbital and
      intraocular IgG4-ROD with a focus on publications since 2016. RECENT FINDINGS:
      Case reports of scleritis and uveitis in IgG4-ROD have been described since 2012.
      Systemic prednisone is recommended as the first-line treatment, but
      immunosuppressive therapy may be required for steroid-sparing or in
      steroid-resistant cases. High rates of systemic IgG4-RD involvement exist in
      patients with bilateral IgG4-ROD or if the lacrimal gland is involved. Rituximab 
      is the most specific immune targeted therapy available with high rates of
      remission. SUMMARY: IgG4-ROD is an emerging cause of scleritis and uveitis and
      should be considered in any patient with multisystem inflammatory disease. New
      targeted immune therapies may improve outcomes and lead to clinical remission.
FAU - Derzko-Dzulynsky, Larissa
AU  - Derzko-Dzulynsky L
AD  - University of Toronto, Department of Ophthalmology and Vision Sciences, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Ophthalmol
JT  - Current opinion in ophthalmology
JID - 9011108
RN  - 0 (Glucocorticoids)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Dacryocystitis/diagnosis/drug therapy/immunology
MH  - Eye Diseases/diagnosis/drug therapy/*immunology
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - *Immunoglobulin G/immunology
MH  - Immunosuppressive Agents/therapeutic use
MH  - Orbital Pseudotumor/diagnosis/drug therapy/immunology
MH  - Paraproteinemias/diagnosis/drug therapy/*immunology
MH  - Scleritis/diagnosis/drug therapy/immunology
MH  - Uveitis/diagnosis/drug therapy/immunology
EDAT- 2017/09/01 06:00
MHDA- 2017/10/17 06:00
CRDT- 2017/09/01 06:00
PHST- 2017/09/01 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
PHST- 2017/09/01 06:00 [entrez]
AID - 10.1097/ICU.0000000000000427 [doi]
PST - ppublish
SO  - Curr Opin Ophthalmol. 2017 Nov;28(6):617-622. doi: 10.1097/ICU.0000000000000427.