PMID- 28855207
OWN - NLM
STAT- MEDLINE
DCOM- 20171106
LR  - 20180413
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Linking)
VI  - 77
IP  - 20
DP  - 2017 Oct 15
TI  - Shrimp miR-S8 Suppresses the Stemness of Human Melanoma Stem-like Cells by
      Targeting the Transcription Factor YB-1.
PG  - 5543-5553
LID - 10.1158/0008-5472.CAN-17-1375 [doi]
AB  - Cross-species regulation of gene expression by microRNA is a possible untapped
      opportunity for miRNA-based therapy. In this study, we report a novel approach to
      ablate melanoma stem-like cells by targeting the transcription factor YB-1, which
      is significantly and selectively upregulated in these cells in melanoma.
      Silencing YB-1 expression was sufficient to significantly inhibit the stemness of
      melanoma stem-like cells. In exploring YB-1 targeting, we discovered that the
      shrimp microRNA miR-S8 could suppress human YB-1 expression in melanoma stem-like
      cells. Mechanistic investigations revealed that miR-S8 recognized the 3'UTR of
      YB-1 mRNA and mediated its degradation. In tumor cell and xenograft experiments, 
      miR-S8 suppressed the tumorigenic capacity of melanoma stem-like cells by
      targeting human YB-1. Overall, our results illuminated a novel aspect of
      miRNA-mediated cross-species gene expression and its use in regulating cancer
      stem-like cells. Cancer Res; 77(20); 5543-53. (c)2017 AACR.
CI  - (c)2017 American Association for Cancer Research.
FAU - Yang, Fan
AU  - Yang F
AD  - College of Life Sciences and Laboratory for Marine Biology and Biotechnology of
      Qingdao National Laboratory for Marine Science and Technology, Zhejiang
      University, Hangzhou, People's Republic of China.
FAU - Wei, Jun
AU  - Wei J
AD  - College of Life Sciences and Laboratory for Marine Biology and Biotechnology of
      Qingdao National Laboratory for Marine Science and Technology, Zhejiang
      University, Hangzhou, People's Republic of China.
FAU - Zhang, Song
AU  - Zhang S
AD  - College of Life Sciences and Laboratory for Marine Biology and Biotechnology of
      Qingdao National Laboratory for Marine Science and Technology, Zhejiang
      University, Hangzhou, People's Republic of China.
FAU - Zhang, Xiaobo
AU  - Zhang X
AD  - College of Life Sciences and Laboratory for Marine Biology and Biotechnology of
      Qingdao National Laboratory for Marine Science and Technology, Zhejiang
      University, Hangzhou, People's Republic of China. zxb0812@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170830
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (3' Untranslated Regions)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
RN  - 0 (Y-Box-Binding Protein 1)
RN  - 0 (YBX1 protein, human)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Animals
MH  - Artemia
MH  - Carcinogenesis/genetics
MH  - Cell Line, Tumor
MH  - Heterografts
MH  - Humans
MH  - Melanoma/*genetics/pathology/therapy
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, Nude
MH  - Mice, SCID
MH  - MicroRNAs/*administration & dosage/*genetics
MH  - Neoplastic Stem Cells/pathology/*physiology
MH  - RNA, Messenger/genetics
MH  - Transfection
MH  - Y-Box-Binding Protein 1/*genetics
EDAT- 2017/09/01 06:00
MHDA- 2017/11/07 06:00
CRDT- 2017/09/01 06:00
PHST- 2017/05/11 00:00 [received]
PHST- 2017/08/01 00:00 [revised]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2017/09/01 06:00 [pubmed]
PHST- 2017/11/07 06:00 [medline]
PHST- 2017/09/01 06:00 [entrez]
AID - 0008-5472.CAN-17-1375 [pii]
AID - 10.1158/0008-5472.CAN-17-1375 [doi]
PST - ppublish
SO  - Cancer Res. 2017 Oct 15;77(20):5543-5553. doi: 10.1158/0008-5472.CAN-17-1375.
      Epub 2017 Aug 30.