PMID- 28844053
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 102
IP  - 6
DP  - 2018 Jun
TI  - Non-invasive method of monitoring retinal vasculitis in patients with birdshot
      chorioretinopathy using optical coherence tomography.
PG  - 815-820
LID - 10.1136/bjophthalmol-2016-309837 [doi]
AB  - BACKGROUND/AIMS: To investigate the utility of using montaged optical coherence
      tomography (OCT) thickness maps to monitor perivascular thickness as a marker of 
      vasculitic activity in patients with large-vessel retinal vasculitis. METHODS:
      This is a retrospective cohort study of 22 eyes of 11 patients with a history of 
      retinal vasculitis associated with birdshot chorioretinopathy (BCR). Patients had
      serial spectral domain 6x6 mm cube OCT scans centred on the fovea, optic nerve
      and proximal branches of the superior and inferior retinal vessels. OCT thickness
      change maps for each respective region were analysed. Changes in perivascular
      thickness were confirmed by assessing vasculitic activity on fluorescein
      angiography (FA), when clinically indicated. RESULTS: In three patients, montaged
      OCT scans were acquired at diagnosis and serially through initial treatment. In
      all three patients, montaged OCT demonstrated reduced perivascular thickening
      with oral prednisone treatment, which was confirmed by FA showing reduced
      vascular leakage in both eyes. Eight patients had serial montaged OCT scans after
      diagnosis and initial treatment of BCR. Four of these patients showed
      fluctuations in perivascular thickness during flares and treatment that were
      confirmed by either increased or decreased vascular leakage on FA. The other four
      patients remained quiet on their immunosuppressive treatment regimens, and no
      changes in perivascular thickness were detected. CONCLUSIONS: Evaluating
      large-vessel perivascular thickness on OCT scans may be a useful method for
      non-invasively monitoring posterior pole large-vessel retinal vasculitis.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text
      of the article) 2018. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Knickelbein, Jared E
AU  - Knickelbein JE
AD  - National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
FAU - Tucker, William
AU  - Tucker W
AD  - National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
FAU - Kodati, Shilpa
AU  - Kodati S
AD  - National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
FAU - Akanda, Marib
AU  - Akanda M
AD  - National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
FAU - Sen, H Nida
AU  - Sen HN
AD  - National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20170826
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - Birdshot chorioretinopathy
SB  - IM
MH  - Adult
MH  - Chorioretinitis/*diagnostic imaging/pathology
MH  - Female
MH  - Fluorescein Angiography/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retinal Vasculitis/*diagnostic imaging
MH  - Retinal Vessels/diagnostic imaging
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/instrumentation/*methods
OTO - NOTNLM
OT  - *birdshot chorioretinopathy
OT  - *fluorescein angiography
OT  - *optical coherence tomography
OT  - *retinal vasculitis
COIS- Competing interests: None declared.
EDAT- 2017/08/28 06:00
MHDA- 2019/02/12 06:00
CRDT- 2017/08/28 06:00
PHST- 2016/11/03 00:00 [received]
PHST- 2017/07/07 00:00 [revised]
PHST- 2017/08/14 00:00 [accepted]
PHST- 2017/08/28 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2017/08/28 06:00 [entrez]
AID - bjophthalmol-2016-309837 [pii]
AID - 10.1136/bjophthalmol-2016-309837 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2018 Jun;102(6):815-820. doi: 10.1136/bjophthalmol-2016-309837. 
      Epub 2017 Aug 26.