PMID- 28842757
OWN - NLM
STAT- In-Data-Review
LR  - 20180119
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 33
IP  - 2
DP  - 2018 Feb
TI  - Successful long-term outcome of pediatric liver-kidney transplantation: a
      single-center study.
PG  - 351-358
LID - 10.1007/s00467-017-3782-5 [doi]
AB  - INTRODUCTION: Liver-kidney transplantation is a rare procedure in children, with 
      just ten to 30 cases performed annually worldwide. The main indications are
      autosomal recessive polycystic liver-kidney disease and primary hyperoxaluria.
      This study aimed to report outcomes of liver-kidney transplantation in a cohort
      of pediatric patients. METHODS: We retrospectively analyzed all pediatric
      liver-kidney transplantations performed in our center between September 2000 and 
      August 2015. Patient data were obtained by reviewing inpatient and outpatient
      medical records and our transplant database. RESULTS: A total of 14 liver-kidney 
      transplants were performed during the study period, with a median patient age and
      weight at transplant of 144.4 months (131.0-147.7) and 27.3 kg (12.0-45.1),
      respectively. The indications for liver-kidney transplants were autosomal
      recessive polycystic liver-kidney disease (8/14), primary hyperoxaluria -1
      (5/14), and idiopathic portal hypertension with end-stage renal disease (1/14).
      Median time on waiting list was 8.5 months (5.7-17.3). All but two liver-kidney
      transplants were performed simultaneously. Patients with primary hyperoxaluria-1 
      tended to present a delayed recovery of renal function compared with patients
      transplanted for other indications (62.5 vs 6.5 days, respectively, P 0.076).
      Patients with liver-kidney transplants tended to present a lower risk of acute
      kidney rejection than patients transplanted with an isolated kidney transplant
      (7.2% vs 32.7%, respectively; P < 0.07). Patient and graft survival at 1, 3, and 
      5 years were 100%, 91.7%, 91.7%, and 91.7%, 83.3%, 83.3%, respectively. No other 
      grafts were lost. CONCLUSION: Long-term results of liver-kidney transplants in
      children are encouraging, being comparable with those obtained in isolated liver 
      transplantation.
FAU - Quintero Bernabeu, Jesus
AU  - Quintero Bernabeu J
AD  - Pediatric Hepatology and Liver Transplant Unit, Hospital Universitari Vall
      d'Hebron, Universitat Atonoma de Barcelona, 08035, Barcelona, Spain.
      38633jqb@gmail.com.
FAU - Juamperez, Javier
AU  - Juamperez J
AD  - Pediatric Hepatology and Liver Transplant Unit, Hospital Universitari Vall
      d'Hebron, Universitat Atonoma de Barcelona, 08035, Barcelona, Spain.
FAU - Munoz, Marina
AU  - Munoz M
AD  - Pediatric Nephrology Department, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, 08035, Barcelona, Spain.
FAU - Rodriguez, Olalla
AU  - Rodriguez O
AD  - Pediatrics Department, Hospital Universitari Vall d'Hebron, Universitat Autonoma 
      de Barcelona, 08035, Barcelona, Spain.
FAU - Vilalta, Ramon
AU  - Vilalta R
AD  - Pediatric Nephrology Department, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, 08035, Barcelona, Spain.
FAU - Molino, Jose A
AU  - Molino JA
AD  - Pediatric Surgery Department, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, 08035, Barcelona, Spain.
FAU - Asensio, Marino
AU  - Asensio M
AD  - Pediatric Surgery Department, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, 08035, Barcelona, Spain.
FAU - Bilbao, Itxarone
AU  - Bilbao I
AD  - HPB Surgery and Transplants, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, 08035, Barcelona, Spain.
FAU - Ariceta, Gema
AU  - Ariceta G
AD  - Pediatric Nephrology Department, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, 08035, Barcelona, Spain.
FAU - Rodrigo, Carlos
AU  - Rodrigo C
AD  - Pediatrics Department, Hospital Universitari Vall d'Hebron, Universitat Autonoma 
      de Barcelona, 08035, Barcelona, Spain.
FAU - Charco, Ramon
AU  - Charco R
AD  - HPB Surgery and Transplants, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, 08035, Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170825
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
OTO - NOTNLM
OT  - Allograft survival
OT  - Donor-specific antibodies
OT  - Highly sensitized patients
OT  - Liver-kidney transplantation
OT  - Pediatrics
EDAT- 2017/08/27 06:00
MHDA- 2017/08/27 06:00
CRDT- 2017/08/27 06:00
PHST- 2017/03/18 00:00 [received]
PHST- 2017/08/02 00:00 [accepted]
PHST- 2017/07/04 00:00 [revised]
PHST- 2017/08/27 06:00 [pubmed]
PHST- 2017/08/27 06:00 [medline]
PHST- 2017/08/27 06:00 [entrez]
AID - 10.1007/s00467-017-3782-5 [doi]
AID - 10.1007/s00467-017-3782-5 [pii]
PST - ppublish
SO  - Pediatr Nephrol. 2018 Feb;33(2):351-358. doi: 10.1007/s00467-017-3782-5. Epub
      2017 Aug 25.